Selected since 2006.
*: Correspondence, Present or past group members of the research group: underlined



  • Araki Y., Miura Y., Fujiwara H. Exploration of novel biomarkers for hypertensive disorders of pregnancy by comprehensive analysis of peptide fragments in blood: their potential and technologies supporting quantification. Chem.Lab.Med. 60: 44-51, 2022. doi: 10.1515/cclm-2021-0713
  • Araki Y. Embryos, cancers, and parasites: potential applications to the study of reproductive biology in view of their similarity as biological phenomena. Med.Biol. 21: e12447, 2022. doi: 10.1002/rmb2.12447
  • Sendo F., Yoshitake H., Araki Y. Targeting neutrophil activation in the early phase of coronavirus disease 2019 to reduce disease severity. Immunol. 2022 (in press)


  • Araki Y*., Yoshitake H.Yamatoya K., Fujiwara H.  An overview of sex and reproductive immunity from an evolutionary/anthropological perspective.  Immunol.Med.44: 152-158, 2021. https://doi.org/10.1080/25785826.2020.1831219
  • Araki Y*. Commentary on a “Strategy to develop clinical peptide biomarkers for more accurate evaluation of the pathophysiological status of hypertensive disorders of pregnancy”. Clinics Mother Child Health,  18:1000370, 2021. doi: 10.35248/2090-7214.21.18.370
  • Okubo M*, Furuta Y, Nakamura Y, Osawa T, Tada N, Sawada T, Yamatoya K, Sekiguchi Y, Araki Y, Miyake K, Noguchi M, Komatsu N, Ohsaka A. Threshold for optimal administration of plerixafor in autologous peripheral blood stem cell collections through CD34+ cell monitoring based on the experience from two Japanese university hospitals. Ther.Apher.Dial. 25:687-696, 2021. https://doi.org/10.1111/1744-9987.13614
  • Wakabayashi I., Yanagida M., Araki Y. Associations of blood pressure and serum lipids with circulating peptides related to hypertensive disorders of pregnancy. Hypertension Res. 44:1641-1651, 2021.doi: 10.1038/s41440-021-00747-6


  • Yoshitake H.Araki Y.* Role of the glycosylphosphatidylinositol-anchored protein TEX101, and its related molecules in spermatogenesis.  Int.J.Mol.Sci, 21, 6628 2020. doi:10.3390/ijms21186628
  • Fujiwara H*., Ono M., Sato Y., Imakawa K., Iizuka T., Kagami K., Fujiwara T., Horie A., Tani H., Hattori A., Daikoku T., Araki Y.  Promoting roles of embryonic signals in embryo implantation and placentation in cooperation with endocrine and immune systems.  Int.J.Mol.Sci. 21, 1885, 2020. doi:10.3390/ijms2105188
  • Yamatoya K*., Kousaka M., Ito C., Nakata K., Hatano M., Araki Y., Toshimori K. Cleavage of SPACA1 regulates assembly of sperm-egg membrane fusion machinery in mature spermatozoa. Biol.Reprod. 102:750-757, 2020. doi:10.1093/biolre/ioz223
  • Araki Y*, Yanagida M. Hypertensive disorders of pregnancy: strategy to develop clinical peptide biomarkers for more accurate evaluation of the pathophysiological status of this syndrome. In: Adv Clin Chem (Makowski GS. ed.) Vol. 94, pp1-30, Elsevier, London, UK, 2020. (Cover Image: https://doi.org/10.1016/bs.acc.2019.07.007)
  • Tanaka K., Tanaka T., Nakano T., HozumI Y., Yanagida M., ArakI Y., Iwazaki K., Takagi M., Goto K*. Knockdown of DEAD-box RNA helicase DDX5 selectively attenuates serine 311 phosphorylation of NF-κB p65 subunit and expression level of anti-apoptotic factor Bcl-2. Cell. Signal. 65:109428, 2020. doi: 10.1016/j.cellsig.2019.109428



  • Fujiwara H*, Matsumoto H, Sato Y, Horie A, Ono M, Nakamura M, Mizumoto Y, Kagami K, Fujiwara T, Hattori A, Maida Y, Daikoku T, Imakawa K, Araki Y. Factors regulating human extravillous trophoblast invasion: Chemokine-peptidase and CD9-integrin systems.Cur.Pharm.Biotech. 19: 764-770, 2018. doi: 10.2174/138920101910181112114656
  • Hamamura K, Yanagida M, Ishikawa H, Banzai M, Yoshitake H, Nonaka D, Tanaka K, Sakuraba M, Miyakuni Y, Takamori K, Nojima M, Yoshida K, Fujiwara H, Takeda S, Araki Y*. Quantitative measurement of a candidate serum biomarker peptide derived from α2-HS-glycoprotein, and a preliminary trial of multi-dimensional peptide analysis in women with pregnancy induced hypertension. Ann.Clin.Biochem. 55:287-295, 2018. doi: 10.1177/0004563217717748


  • Suginami K, Sato Y, Horie A, Matsumoto H, Tani H, Mizumoto Y, Matsuoka A, Kyo S, Araki Y, Konishi I., Fujiwara H*. Platelet-derived microparticles and soluble factors differentially regulate human endometrial epithelial cell movement.Am.J.Reprod.Immunol. 77:e12641, 2017. doi: 10.1111/aji.12641.
  • Suginami K, Sato Y, Horie A, Matsumoto H, Kyo S, Araki Y, Konishi I, Fujiwara H*. Platelets are a possible regulator of human endometrial re-epithelialization during menstruation. Am.J.Reprod.Immunol. 77:e12609, 2017. doi: 10.1111/aji.12609.


  • Matsumoto H, Sato Y, Horie A, Suginami K, Tani H, Hattori A, Araki Y, Kagami K, Konishi I, Fujiwara H*. CD9 suppresses human extravillous trophoblast invasion. Placenta 47:105-112, 2016. doi: 10.1016/j.placenta.2016.09.014
  • Yoshitake H, Oda R, Yanagida M, Kawasaki Y, Sakuraba M, Takamori K, Hasegawa A, Fujiwara H, Araki Y*. Identification of an anti-sperm auto-monoclonal antibody (Ts4)-recognized molecule in the mouse sperm acrosomal region and its inhibitory effects on fertilization in vitro. J.Reprod.Immunol. 115: 6-13, 2016. doi:10.1016/j.jri.2016.04.001
  • Endo S, Yoshitake H, Tsukamoto H, Matsuura H, Kato K, Sakuraba M, Takamori K, Fujiwara H, Takeda S, Araki Y.* TEX101, a glycoprotein essential for sperm fertility, is required for stable expression of Ly6k on testicular germ cells. Sci.Rep. 6: 23616, 2016. doi: 10.1038/srep23616.
  • Fujiwara H*, Araki Y, Sato Y, Takakura M, Nakamura M, Mizumoto Y, Horie A, Kanzaki H, Mori T. Role of circulating blood cells in maternal tissue remodeling and embryo-maternal cross talk.In: Uterine Endometrial Function (Kanzaki H. ed.) pp. 49-60, Springer Japan, Tokyo, Japan, 2016.
  • Hamamura K, Nonaka D., Ishikawa H., Banzai M., Yoshitake H, Yanagida M, Nojima M, Yoshida K, Takamori K, Asada K, Lee L-J, Tanaka K, Takeda S, Araki Y*. Simple quantitation for potential serum disease biomarker peptides, primarily identified by a peptidomics approach in the serum with hypertensive disorders of pregnancy. Ann.Clin.Biochem. 53: 85-96, 2016. doi:10.1177/0004563215583697.
  • Fujiwara H*, Araki Y, Imakawa K, Saito S, Daikoku T, Shigeta M, Kanzaki H, Mori T. Dual positive regulation of embryo implantation by endocrine and immune systems – Step-by-Step maternal recognition of the developing embryo. Am.J.Reprod.Immunol. 75: 281-289, 2016. doi:10.1111/aji.12478.


  • Bodogai M, Moritoh K, Lee-Chang C, Hollander MC, Sherman-Baust C, Wersto R, Araki Y., Miyoshi I, Yang L, Trinchieri G, Biragyn A*. Regulatory and pro-metastatic function of myeloid-derived suppressive cells requires education from tumor-associated B cells. Cancer Res. 75: 3456-3465, 2015, doi: 10.1158/0008-5472.CAN-14-3077.
  • Fujiwara H*, Araki Y, Saito S, Imakawa K, Kyo S, Shigeta M, Shiotani M, Horie A, Mori T. A novel concept of Fundus-Ovary-Salpinx-Para-Aorta implantation promoting unit during human embryo implantation. In: New Discoveries of Embryology (Wu B. ed.) pp77-95, InTech Open Access Publisher, Rijeka, Croatia. 2015. DOI:10.5772/60634
  • Yoshitake H, Hashii N, Kawasaki N., Endo S., Takamori K., Hasegawa A., Fujiwara H., Araki Y.* Chemical characterization of N-linked oligosaccharide as the antigen epitope recognized by an anti-sperm auto-monoclonal antibody, Ts4. PLOS ONE 10: e0133784, 2015, doi: 10.1371/journal.pone.0133784


  • Kantake M*, Yoshitake H, Ishikawa H, Araki Y, Shimizu T. Postnatal epigenetic modification of glucocorticoid receptor gene in preterm infants: a prospective cohort study. BMJ Open 4: e005318. doi:10.1136/bmjopen-2014-005318, 2014.
  • Sherman-Baust CA, Kuhn E, Valle BL, Shih I-M, Kurman RJ, Wang TL, Amano T, Ko MHS, Miyoshi I, Araki Y, Lehrmann E, Zhang Y, Becker KG, Morin PJ. A genetically engineered ovarian cancer mouse model based on fallopian tube transformation mimics human high-grade serous carcinoma development. J Pathol. 233: 228-237, 2014.


  • Araki Y*, Nonaka D, Hamamura K, Yanagida M, Ishikawa H, Banzai M, Maruyama M, Endo S, Tajima A, Lee L-J, Nojima M, Takamori K, Yoshida K, Takeda S, Tanaka K. Clinical peptidomic analysis by a one-step direct transfer technology: Its potential utility for monitoring of pathophysiological status in female reproductive system disorders. J. Obstet. Gynecol. Res. 39:1440-1448, 2013.
  • Fujihara Y, Tokuhiro K, Muro Y, Kondoh G, Araki Y, Ikawa M, Okabe M*. Expression of TEX101, regulated by ACE, is essential for the production of fertile mouse spermatozoa. Proc.Natl.Acad.Sci. U.S.A. 110:8111-8116, 2013.
  • Honda M*, Asai T, Oku N, Araki Y, Tanaka M, Ebihara N. Liposomes and nanotechnology in drug development: Focus on ocular targets. Int. J. Nanomed. 8; 495-504, 2013.
  • Fujiwara H*, Nishioka Y, Matsumoto H, Suginami K, Horie A, Tani H, Matsumura N, Baba T, Sato Y, Araki Y, Konishi I. Eph-ephrin A system regulates human choriocarcinoma-derived JEG-3 cell invasion. Int.J.Gynecol.Cancer 23:576-582, 2013.
  • Yoshitake H, Yokoi H, Ishikawa H, Maruyama M, Endo S, Nojima M, Yoshida K, Yoshikawa H, Suzuki F, Takamori K, Fujiwara H, Araki Y*. Overexpression of TEX101, a potential novel cancer marker, in head and neck squamous cell carcinoma. Cancer Biomark. 12:141-148, 2012/2013.


  • Okada M, Hozumi Y, Tanaka T, Suzuki Y, Yanagida M, Araki Y, Evangelisti C, Yagisawa H, Matthew K, Topham MK, Martelli AM, Goto K* DGKζ is degraded through the cytoplasmic ubiquitin-proteasome system under excitotoxic conditions, which causes neuronal apoptosis because of aberrant cell cycle reentry. Cell. Signal. 24:1573-1582, 2012.
  • Fujiwara H*, Sato Y, Ideta A, Aoyagi Y, Araki Y, Imakawa K. Immune regulation of human embryo implantation by circulating blood cells. In: The Human Embryo (Yamada S., Takakuwa T. eds), P61-72, InTech Open Access Publisher, Rijeka, Croatia. 2012.
  • Okada M, Hozumi Y, Iwazaki K, Misaki K, Yanagida M, Araki Y, Watanabe T, Yagisawa H, Topham MK, Kaibuchi K, Goto K*. DGKζ is involved in LPS-activated phagocytosis through IQGAP1/Rac1 pathway. Biochem.Biophys.Res.Commun. 420:479-484., 2012.
  • Takizawa T, Ishikawa T, Kosuge T, Mizuguchi Y, Sato Y, Koji T, Araki Y, Takizawa T*. Gene suppression of mouse testis in vivo using small interfering RNA derived from plasmid vectors. Acta Histochem.Cytochem. 45;77-81, 2012.


  • Yoshitake H, Yanagida M, Maruyama M, Takamori K, Hasegawa A, Araki Y*. Molecular characterization and expression of dipeptidase 3, a testis-specific membrane bound dipeptidase related to an anti-sperm auto-monoclonal antibody epitope. J.Reprod.Immunol. 90:202-213, 2011.
  • Araki Y*, Nonaka D, Tajima A, Maruyama M, Nitto T, Ishikawa H, Yoshitake H, Yoshida E, Kuronaka N, Asada K, Yanagida M, Nojima M, Yoshida K, Takamori K, Hashiguchi T, Maruyama I, Lee L-J, Tanaka K. Quantitative peptidomic analysis by a newly developed one-step direct transfer technology without depletion of major blood proteins: Its potential utility for monitoring of pathophysiological status in pregnancy-induced hypertension. Proteomics 11:2727-2737, 2011.
  • Honda M*, Asai T, Umemoto T, Araki Y, Oku N, Tanaka M. Supressioion of choroidal neovascularization by single intravitreal injection of APRPG-modified liposomes encapsulating SU5416. Arch Ophthalmol 129: 317-321, 2011.


  • Lei Z*, Lin J, Li X, Li S, Zhou H, Araki Y, Lan Z-J. Postnatal male germ cell expression of the Cre recombinase in Tex101-iCre transgenic mice. Genesis 48: 717-722, 2010.
  • Fujiwara H, Ideta A, Araki Y, Takao Y, Sato Y, Horie A, Tsunoda N, Aoyagi Y, Konishi I. Possible contribution of circulating blood cells to embryo implantation. Indian J.Physiol.Pharmacol. 54, Suppl 1:51-60, 2010.
  • Maruyama M, Yoshitake H, Tsukamoto H, Takamori K, Araki Y*. Molecular expression of Ly6k, a glycosylphosphatidyl-inositol anchored membrane protein on the mouse testicular germ cells. Biochem.Biophys.Res.Commun. 402:75-81, 2010.
  • Wakabayashi I*, Araki Y. Influences of gender and age on relationships between alcohol drinking and atherosclerotic risk factors. Alcohol.Clin.Exp.Res. 34:S54-60, 2010.


  • Yamatoya K, Yoshida K, Ito C, Maekawa M, Yanagida M, Takamori K, Ogawa H, Araki Y, Miyado K, Toyama Y, Toshimori K*. Equatorin: identification and characterization of the epitope of the MN9 antibody in the mouse. Biol.Reprod. 81:889-897, 2009.
  • Fujiwara H, Araki Y, Toshimori K. Is the zona pellucida an intrinsic source of signals activating maternal recognition of the developing mammalian embryo J.Reprod.Immunol. 81:1-8, 2009.
  • Shirai Y, Yoshitake H, Maruyama M, Takamori K, Ogawa H, Hasagawa A, Araki Y*. Distribution of molecular epitope for Ts4, an anti-sperm auto-monoclonal antibody in the fertilization process. J.Reprod.Dev. 55:240-246, 2009.
  • Fujiwara H*, Ideta A, Araki Y, Takao Y, Sato Y, Tsunoda N, Aoyagi Y, Konishi I. Immune system cooperatively supports endocrine system-primed embryo implantation. J.Mammal.Ova.Res. 26:122-128, 2009.
  • Wakabayashi I*, Araki Y. Associations of alcohol drinking with blood pressure and serum lipids in female smokers and nonsmokers. Gender Med. 6:290-299, 2009.


  • Yoshitake H, Tsukamoto H, Maruyama-Fukushima M, Takamori K, Ogawa H, Araki Y*. TEX101, a germ cell marker glycoprotein is associated with lymphocyte antigen 6 complex locus k within the mouse testis. Biochem.Biophys.Res.Commun. 372:277-282, 2008.
  • Yoshitake H, Shirai Y, Mochizuki Y, Iwanari H, Tsubamoto H, Koyama K, Takamori K, Ogawa H, Hasegawa A, Kodama T, Hamakubo T, Araki Y*. Molecular diversity of TEX101, a marker glycoprotein for germ cells monitored with monoclonal antibodies: Variety of the molecular characteristics according to its subcellular localization within the mouse testis. J.Reprod.Immunol. 79:1-11, 2008.


  • Yoshitake H, Takahashi M, Ishikawa H, Nojima M, Iwanari H, Watanabe A, Aburatani H, Yoshida K, Ishi K, Takamori K, Ogawa H, Hamakubo T, Kodama T, Araki Y*. Aldo-keto reductase family 1, member B10 in uterine carcinomas: a potential risk factor of recurrence after surgical therapy in cervical cancer. Int.J.Gynecol.Cancer 17: 1300-1306, 2007.
  • Nitto T, Takeda Y, Yoshitake H, Sendo F, Araki Y*. Structural divergence of GPI-80 in activated neutrophils. Biochem.Biophys.Res.Commun. 359:227-233, 2007.
  • Tsukamoto H, Takizawa T, Takamori K, Ogawa H, Araki Y*. Genomic organization and structure of the 5′-flanking region of the TEX101 gene: Alternative promoter usage and splicing generate transcript variants with distinct 5′-untranslated region. Mol.Reprod.Dev. 74:154-162, 2007.
  • Suzuki K, Yu X, Chaurand P, Araki Y, Lareyre JJ, Caprioli RM, Orgebin-Crist MC, Matusik RJ. Epididymis-specific lipocalin promoters. Asian J.Androl. 9:515-521, 2007.


  • Jin H, Yoshitake H, Tsukamoto H, Takahashi M, Mori M, Takizawa T, Takamori K, Ogawa H, Kinoshita K, Araki Y. Molecular characterization of a germ cell-specific antigen, TEX101, from mouse testis. Zygote 14:201-208, 2006.
  • Tsukamoto H, Yoshitake H, Mori M, Yanagida M, Takamori K, Ogawa H, Takizawa T, Araki Y*. Testicular proteins associated with the germ cell-specific protein, TEX101: Involvement of cellubrevin in TEX101-trafficking to the germ cell surface during spermatogenesis. Biochem.Biophys.Res.Commun. 345:229-238, 2006.
  • Suzuki K, Yu X, Chaurand P, Araki Y, Lareyre JJ, Caprioli RM, Matusik RJ, Orgebin-Crist MC. Epididymis-specific promoter-driven gene targeting: A transcription factor which regulates epididymis-specific gene expression. Mol.Cell.Endocrinol. 250:184-189, 2006.