自己免疫疾患の研究

業績一覧

2022年

  • Hayakawa K, Fujishiro M, Yoshida Y, Kataoka Y, Sakuma S, Nishi T, Ikeda K, Morimoto S, Takamori K, Sekigawa I. Exposure of female NZBWF1 mice to imiquimod-induced lupus nephritis at an early age via a unique mechanism that differed from spontaneous onset. Clin Exp Immunol. 2022;208(1):33-46. https://www.ncbi.nlm.nih.gov/pubmed/35560182

2021年

  • Matsuoka Y, Morimoto S, Fujishiro M, Hayakawa K, Kataoka Y, Suzuki S, Ikeda K, Takamori K, Yamaji K, Tamura N. Metformin repositioning in rheumatoid arthritis. Clin Exp Rheumatol. 2021;39(4):763-8. https://www.ncbi.nlm.nih.gov/pubmed/32828146

2020年

  • Yoshida Y, Hayakawa K, Fujishiro M, Ikeda K, Tsushima H, Hirai T, Kawasaki M, Tominaga M, Suga Y, Takamori K, Watanabe Y, Sekigawa I, Morimoto S. Social defeat stress exacerbates atopic dermatitis through downregulation of DNA methyltransferase 1 and upregulation of C-C motif chemokine receptor 7 in skin dendritic cells. Biochem Biophys Res Commun. 2020;529(4):1073-9. https://www.ncbi.nlm.nih.gov/pubmed/32819567

2019年

  • Hayakawa K, Kawasaki M, Hirai T, Yoshida Y, Tsushima H, Fujishiro M, Ikeda K, Morimoto S, Takamori K, Sekigawa I. MicroRNA-766-3p Contributes to Anti-Inflammatory Responses through the Indirect Inhibition of NF-kappaB Signaling. Int J Mol Sci. 2019;20(4):809. https://www.ncbi.nlm.nih.gov/pubmed/30769772

2018年

  • Niimi N, Miyashita T, Tanji K, Hirai T, Watanabe K, Ikeda K, Morimoto S, Sekigawa I.
    Aortic Aneurysm as a Complication of Granulomatosis with Polyangiitis Successfully Treated with Prednisolone and Cyclophosphamide: A Case Report and Review of the Literature.
    Case Rep Rheumatol. 2018 Jun 5;2018:9682801.
  • Ikeda K, Sekiguchi N, Hirai T, Tanji K, Zushi A, Inoue M, Takasago M, Komatsu T, Morimoto S, Yamaji K, Takamori K, Tamura N, Sekigawa I.
    Securely collecting multidimensional health information from patients with rheumatoid arthritis using smart device technology: Beneficial effect for physicians and patients.
    Musculoskeletal Care. 2018 Dec;16(4):494-499.
  • Hayakawa K, Ikeda K, Fujishiro M, Yoshida Y, Hirai T, Tsushima H, Miyashita T, Morimoto S, Suga Y, Takamori K, Ogawa H, Sekigawa I.
    Connective Tissue Growth Factor Neutralization Aggravates the Psoriasis Skin Lesion: The Analysis of Psoriasis Model Mice and Patients.
    Ann Dermatol. 2018 Feb;30(1):47-53.
  • Hirai T, Ikeda K, Tsushima H, Fujishiro M, Hayakawa K, Yoshida Y, Morimoto S, Yamaji K, Takasaki Y, Takamori K, Tamura N, Sekigawa I.
    Circulating plasma microRNA profiling in patients with polymyositis/dermatomyositis before and after treatment: miRNA may be associated with polymyositis/dermatomyositis.
    Inflamm Regen. 2018 Jan 8;38:1.

2017年

  • Nozawa K, Doe K, Uomori K, Sekigawa I, Takasaki Y, Yamaji K, Tamura N.
    Antiribonuclease H2 antibodies are an immune biomarker for systemic lupus erythematosus.
    Autoimmunity. 2017 Jun;50(4):241-246.
  • Ikeda K, Watanabe K, Hirai T, Tanji K, Miyashita T, Nakajima S, Uomori K, Morimoto S, Takamori K, Ogawa H, Takasaki Y, Sekigawa I.
    Mizoribine Synchronized Methotrexate Therapy should be Considered when Treating Rheumatoid Arthritis Patients with an Inadequate Response to Various Combination Therapies.
    Intern Med. 2017;56(10):1147-1152.
  • Ikeda K, Nakajima S, Tanji K, Hirai T, Uomori K, Morimoto S, Tomita S, Fukunaga M, Tamura N, Sekigawa I.
    Intestinal perforation due to hemorrhagic Cytomegalovirus enteritis in a patient with severe uncontrolled lupus nephritis: a case and review of the literature.
    Rheumatol Int. 2017 Aug;37(8):1395-1399.
  • Hirai T, Ikeda K, Fujishiro M, Tsushima H, Hayakawa K, Suzuki S, Yamaguchi A, Nozawa K, Morimoto S, Takasaki Y, Ogawa H, Takamori K, Tamura N, Sekigawa I.
    The effectiveness of new triple combination therapy using synthetic disease-modifying anti-rheumatic drugs with different pharmacological function against rheumatoid arthritis: the verification by an in vitro and clinical study.
    Clin Rheumatol. 2017 Jan;36(1):51-58.
  • Matsuki-Muramoto Y, Nozawa K, Uomori K, Sekigawa I, Takasaki Y.
    Bortezomib treatment prevents glomerulosclerosis associated with lupus nephritis in a murine model through suppressive effects on the immune and renin-angiotensin systems.
    Mod Rheumatol. 2017 Jan;27(1):77-86.

2016年

  • Uomori K, Nozawa K, Ikeda K, Doe K, Yamada Y, Yamaguchi A, Fujishiro M, Kawasaki M, Morimoto S, Takamori K, Sekigawa I, Chan EK, Takasaki Y.
    A re-evaluation of anti-NA-14 antibodies in patients with primary Sjogren’s syndrome: Significant role of interferon-γ in the production of autoantibodies against NA-14.
    Autoimmunity. 2016 Aug;49(5):347-56.
  • Miyashita T, Morimoto S, Fujishiro M, Hayakawa K, Suzuki S, Ikeda K, Miyazawa K, Morioka M, Takamori K, Ogawa H, Sekigawa I, Takasaki Y.
    Inhibition of each module of connective tissue growth factor as a potential therapeutic target for rheumatoid arthritis.
    Autoimmunity. 2016;49(2):109-14.
  • Ikeda K, Takasaki Y, Sekigawa I.
    Rapid onset of small intestinal perforation after successful steroid treatment in eosinophilic granulomatosis with polyangiitis.
    Mod Rheumatol. 2016 Nov;26(6):968-970.

2015年

  • Suzuki S, Morimoto S, Fujishiro M, Kawasaki M, Hayakawa K, Miyashita T, Ikeda K, Miyazawa K, Yanagida M, Takamori K, Ogawa H, Sekigawa I, Takasaki Y.
    Inhibition of the insulin-like growth factor system is a potential therapy for rheumatoid arthritis.
    Autoimmunity. 2015 Jun;48(4):251-8.
  • Nakano S, Morimoto S, Suzuki S, Tsushima H, Yamanaka K, Sekigawa I, Takasaki Y.
    Immunoregulatory role of IL-35 in T cells of patients with rheumatoid arthritis.
    Rheumatology (Oxford). 2015 Aug;54(8):1498-506.

2014年

  • Nozawa K, Fujishiro M, Takasaki Y, Sekigawa I.
    Inhibition of rheumatoid arthritis by blocking connective tissue growth factor.
    World J Orthop. 2014 Nov 18;5(5):653-9.

2013年

  • Yanagida M, Kawasaki M, Fujishiro M, Miura M, Ikeda K, Nozawa K, Kaneko H, Morimoto S, Takasaki Y, Ogawa H, Takamori K, Sekigawa I.
    Serum proteome analysis in patients with rheumatoid arthritis receiving therapy with tocilizumab: an anti-interleukin-6 receptor antibody.
    Biomed Res Int. 2013;2013:607137.
  • Nozawa K, Fujishiro M, Kawasaki M, Yamaguchi A, Ikeda K, Morimoto S, Iwabuchi K, Yanagida M, Ichinose S, Morioka M, Ogawa H, Takamori K, Takasaki Y, Sekigawa I.
    Inhibition of connective tissue growth factor ameliorates disease in a murine model of rheumatoid arthritis.
    Arthritis Rheum. 2013 Jun;65(6):1477-86.
  • Yamaguchi A, Nozawa K, Fujishiro M, Kawasaki M, Suzuki F, Takamori K, Ogawa H, Takasaki Y, Sekigawa I.
    CC motif chemokine ligand 13 is associated with rheumatoid arthritis pathogenesis.
    Mod Rheumatol. 2013 Sep;23(5):856-63.

2012年

  • Yanagida M, Jung G, Tanaka Y, Sone S, Fujishiro M, Ikeda K, Nozawa K, Kaneko H, Takasaki Y, Ogawa H, Takamori K, Sekigawa I.
    Serum proteome analysis in patients with rheumatoid arthritis receiving therapy with etanercept, a chimeric tumor necrosis factor-alpha receptor.
    Int J Rheum Dis. 2012 Oct;15(5):486-95.
  • Yamaguchi A, Nozawa K, Fujishiro M, Kawasaki M, Takamori K, Ogawa H, Sekigawa I, Takasaki Y.
    Estrogen inhibits apoptosis and promotes CC motif chemokine ligand 13 expression on synovial fibroblasts in rheumatoid arthritis.
    Immunopharmacol Immunotoxicol. 2012 Oct;34(5):852-7.
  • Fujishiro M, Nozawa K, Kawasaki M, Yamaguchi A, Iwabuchi K, Yanagida M, Suzuki F, Miyazawa K, Fukui H, Kaneko K, Ogawa H, Takamori K, Takasaki Y, Sekigawa I.
    Regenerating gene (REG) 1 alpha promotes pannus progression in patients with rheumatoid arthritis.
    Mod Rheumatol. 2012 Apr;22(2):228-37.

2011年

  • Yamada R, Nozawa K, Yoshimine T, Takasaki Y, Ogawa H, Takamori K, Sekigawa I.
    A Case of Thrombotic Thrombocytopenia Purpura Associated with Systemic Lupus Erythematosus: Diagnostic Utility of ADAMTS-13 Activity.
    Autoimmune Dis. 2011;2011:483642.

2010年

  • Kawasaki M, Fujishiro M, Yamaguchi A, Nozawa K, Kaneko H, Takasaki Y, Takamori K, Ogawa H, Sekigawa I.
    Fluctuations in the gene expression of peripheral blood mononuclear cells between the active and inactive phases of systemic lupus erythematosus.
    Clin Exp Rheumatol. 2010 May-Jun;28(3):311-7.
  • Sekigawa I, Fujishiro M, Yamaguchi A, Kawasaki M, Inui A, Nozawa K, Takasaki Y, Takamori K, Ogawa H.
    A new hypothesis of the possible mechanisms of gender differences in systemic lupus erythematosus.
    Clin Exp Rheumatol. 2010 May-Jun;28(3):419-23.

2009年

  • Nozawa K, Fujishiro M, Kawasaki M, Kaneko H, Iwabuchi K, Yanagida M, Suzuki F, Miyazawa K, Takasaki Y, Ogawa H, Takamori K, Sekigawa I.
    Connective tissue growth factor promotes articular damage by increased osteoclastogenesis in patients with rheumatoid arthritis.
    Arthritis Res Ther. 2009;11(6):R174.
  • Nozawa K, Ikeda K, Satoh M, Reeves WH, Stewart CM, Li YC, Yen TJ, Rios RM, Takamori K, Ogawa H, Sekigawa I, Takasaki Y, Chan EK.
    Autoantibody to NA14 is an independent marker primarily for Sjogren’s syndrome.
    Front Biosci (Landmark Ed). 2009 Jan 1;14:3733-9.
  • Nozawa K, Kaneko H, Itoh T, Katsura Y, Noguchi M, Suzuki F, Takasaki Y, Ogawa H, Takamori K, Sekigawa I.
    Synchronous malignant B-cell lymphoma and gastric tubular adenocarcinoma associated with paraneoplastic cutaneous vasculitis: hypereosinophilic syndrome with mixed cryoglobulinemia is an important sign of paraneoplastic syndrome.
    Rare Tumors. 2009 Dec 28;1(2):e42.
  • Morimoto S, Tokano Y, Nakano S, Watanabe T, Tamayama Y, Mitsuo A, Suzuki J, Kaneko H, Sekigawa I, Takasaki Y.
    Chemoattractant mechanism of Th1 cells in class III and IV lupus nephritis.
    Autoimmunity. 2009 Feb;42(2):143-9.

2008年

  • Sekigawa I, Kaneda K, Kaneko H, Takasaki Y, Takamori K, Ogawa H.
    Detection of serum IgE class anti-SSA antibodies in mothers with foetal loss.
    Rheumatol Int. 2008 May;28(7):623-6.

2007年

  • Inui A, Ogasawara H, Naito T, Sekigawa I, Takasaki Y, Hayashida Y, Takamori K, Ogawa H.
    Estrogen receptor expression by peripheral blood mononuclear cells of patients with systemic lupus erythematosus.
    Clin Rheumatol. 2007 Oct;26(10):1675-8.
  • Naito T, Inui A, Kudo N, Matsumoto N, Fukuda H, Isonuma H, Sekigawa I, Dambara T, Hayashida Y.
    Seroprevalence of IgG anti-toxoplasma antibodies in asymptomatic patients infected with human immunodeficiency virus in Japan.
    Intern Med. 2007;46(14):1149-50.