業績

Results

    文部科学省・私立大学戦略的基盤形成支援事業における主な業績（平成26～30年度)

    • *Kawaguchi M, Tamura Y, Kakehi S, Takeno K, Sakurai Y, Watanabe T, Funayama T, Sato F, Ikeda S, Ogura Y, Saga N, Naito H, Fujitani Y, Kanazawa A, Kawamori R, Watada H
      Association between expression of FABPpm in skeletal muscle and insulin sensitivity in intramyocellular-lipid-accumulated non-obese men
      J Clin Endocrinol Metab. 99(9): 3343-52. 2014.

    • *Shimoji K, Uka T, Tamura Y, Yoshida M, Kamagata K, Hori M, Motoi Y, Watada H, Kawamori R,Aoki S
      Diffusional kurtosis imaging analysis in patients with hypertension
      Jpn J Radiol, 32: 98-104, 2014

    • *Miyazaki T, Shimada K, Hki M, Kume A, Kitamura Y, Oshida K, Yanagisawa N, Kiyanagi T, Matsumori R, Daida H.
      High hexacosanoic acid levels are associated with coronary artery disease. 
      Atherosclerosis. 223:429-433;2014.

    • *Hada S, Kaneko H, Sadatsuki R, Liu L, Futami I, Kinoshita M, Yusu A, Saita Y, Takazawa Y, Ikeda H, Kazuo K, Ishijima M．
      The degeneration and destruction of femoral articular cartilage shows a greater degree of deterioration than that of the tibial and patellar articular cartilage in early stage knee osteoarthritis: A cross-sectional study
      Osteoarthritis Cartilage, 22, 1583-9, 2014

    • *S. Kakehi, Y. Tamura, K. Takeno, Y. Sakurai, M.Kawaguchi,  T. Watanabe, T. Funayama, F. Sato, S. Ikeda, A. Kanazawa,Y. Fujitani, R. Kawamori, H. Watada.
      Increased intramyocellular lipid/impaired insulin sensitivity is associated with altered lipid metabolic genes in muscle of high responders to a high fat diet.
      Am J Physiol Endocrinol Metab, 2015; 310 (1): E32-40

    • *Zheng DM, Bian Z, Furuya N, Oliva Trejo JA, Takeda-Ezaki M, Takahashi K, Hiraoka Y,  Mineki R, Taka H, Ikeda S, Komatsu M, Fujimura T, Ueno T, Ezaki J
      A treadmill exercise reactivates the signaling of the mammalian target of rapamycin (mTor) in the skeletal muscles of starved mice.
      Biochem Biophys Res Commun, 2015 Jan 2;456(1):519-26.

    • *Nishitani-Yokoyama M, Miyauchi K, Shimada K, Miyazaki T, Ogita M, Okazaki S, Shioya M, Koba S, Tsujita H, Kobayashi Y, Daida H.
      Effects of phase II comprehensive cardiac rehabilitation on coronary plaque volume after acute coronary syndrome.
      Int Heart J. 56:597-604.2015

    • *Alshahi H, Shimada K, Miyauchi K, Yoshihara T, Sai E, Shiozawa T, Naito R, Aikawa T, Ouchi S, Kadoguchi T, Miyazaki T, Daida H.
      Elevated Circulating Levels of Inflammatory Markers in Patients with Acute Coronary Syndrome.
      International Journal of Vascular Medicine, Volume 2015 (2015), Article ID 805375, 8 pages

    • *Yusup A, Kaneko H, Liu L, Ning L, Sadatsuki R, Hada S, Kamagata K, Kinoshita M, Futami I, Shimura Y, Tsuchiya M, Saita Y, Takazawa Y, Ikeda H, Aoki S, Kaneko K, Ishijima M.
      Bone marrow lesions, subchondral bone cysts and subchondral bone attrition are associated with histological synovitis in patients with end-stage knee osteoarthritis: a cross-sectional study.
      Osteoarthritis Cartilage. 2015 Nov;23(11):1858-64.

    • *Wada, H, Dohi T, Miyauchi K, Shitara J, Endo H, Doi S, Naito R, Konishi H, Tsuboi S, Ogita M, Kasai T, Hassan A, Okazaki S, Isoda K, Shimada K, Suwa S, Daida H.
      Preprocedural high-sensitivity C-reactive protein predicts long-term outcomes in patients undergoing percutaneous coronary intervention.
      Circ J. 90-95:81;2017.

    • *Sai E, Shimada K, Yokoyama T, Hiki M, Sato S, Hamasaki N, Maruyama M, Morimoto R, Miyazaki T, Fujimoto S, Tamura Y, Aoki S, Watada H, Kawamori R, Daida H.
      Myocardial Triglyceride Content in Patients with Left Ventricular Hypertrophy: Comparison between Hypertensive Heart Disease and Hypertrophic Cardiomyopathy.
      Heart Vessels. 2017 Feb;32(2):166-174.

    • *Akita K, Isoda K, Okabayasi Y, Shimada K, Daida H
      Lack of IkBNS accelarates atherosclerosis in LDL receptor-deficinet mice via increased interleukin-6 production
      Int J Cardiol, 2016; 211:61-63

    • *Sadatsuki R, Kaneko H, Futami I,  Kinoshita M, Nonaka R, Culley KL, Otero M, Hada S, Goldring MB, Yamada Y, Kaneko K, Arikawa-Hirasawa E, Ishijima M
      Perlecan is required for the chondrogenic differentiation of synovial mesenchymal cells through regulation of Sox9 gene expression
      J Orthop Res, 2017 Apr;35(4):837-846

    • *Elahi M, Motoi Y, Matsumoto S, Hasan Z, Ishiguro K, Hattori N
      Short-term treadmill exercise increased tau insolubility and neuroinflammation in tauopathy model mice
      Neurosci. Lett. 610　(2016)207-212

    • *Takeno K, Tamura Y, Kawaguchi M, Kakehi S, Watanabe T, Funayama T, Furukawa Y, Kaga H, Yamamoto R, Kim M, Nishitani-Yokoyama M,Shimada K, Daida H, Aoki S, Taka H, Fujimura T, Sawada S, Giacca A, Kanazawa A, Fujitani Y,  Kawamori R, Watada H.
      Relation between insulin sensitivity and metabolic abnormalities in Japanese men with BMI of 23-25 kg/m2.
      J Clin Endocrinol Metab, 2016; 101(10): 3676-3684

    • *Funayama T, Tamura Y, Takeno K, Kawaguchi M, Kakehi S, Watanabe T, Furukawa Y, Kaga H, Yamamoto R, Kanazawa A, Fujitani Y, Kawamori R, Watada H.
      Effects of alcohol abstinence on glucose metabolism in Japanese men with elevated fasting glucose: A pilot study.
      Sci Rep, 2017; 7: 40277

    • *Tsuzuki T, Kobayashi H, Yoshihara T, Kakigi R, Ichinoseki-Sekine N, Naito H.
      Attenuation of exercise-induced heat shock protein 72 expression blunts improvements in whole-body insulin resistance in rats with type 2 diabetes.
      Cell Stress Chaperones. 2017 Mar;22(2):263-269

    • *Eshima H., Tamura Y., Kakehi S., Kurebayashi N., Murayama T., Nakamura K., Kakigi R., Okada T., Sakurai T., Kawamori R. and Watada　H. Long-term, but not short-term high-fat diet induces fiber composition changes and impaired contractile force in mouse fast-twitch skeletal muscle.
      Physiol Rep. 2017;5(7).e13250

    • *Aikawa T, Miyazaki T, Shimada K, Sugita Y, Shimizu M, Ouchi S, Kadoguchi T, Yokoyama Y, Shiozawa T, Hiki M, Takahashi S, Al Shahi H, Dohi S, Amano A, Daida H.
      Low Serum Levels of EPA are Associated with the Size and Growth Rate of Abdominal Aortic Aneurysm.
      J Atheroscler Thromb. 2017, 24(9):912-920

    • *Ikeda S, Tamura Y, Kakehi S, Sanada H, Kawamori R, Watada H.
      Exercise-induced increase in IL-6 level enhances GLUT4 expression and insulin sensitivity in mouse skeletal muscle.
      Biochem Biophys Res Commun, 2016; 473(4): 947-52

    • *Yoshihara T, Shimada K, Fukao K, Sai E, Sato-Okabayashi Y, Matsumori R, Shiozawa T, Alshahi H, Miyazaki T, Tada N, Daida H.
      Omega 3 polyunsaturated fatty acids suppress the development of aortic aneurysms through the inhibition of macrophage-mediated inflammation.
      Circ J. 79:1470-1478;2015

    • *Liu L, Ishijima M, Kaneko H, Futami I, Kurosawa H, Kawasaki T, Kubota M, Yusup A, Sadatsuki R, Saita Y, Takazawa Y, Ikeda H, Kaneko K: Disability for daily living is a predictor for joint replacement in patients with end-stage knee osteoarthritis
      J Bone Miner Metab, 32, 192-99, 2014

    • *Kaga H, Tamura Y, Takeno K, Kakehi S, Funayama T, Furukawa Y, Nishitani-Yokoyama M, Shimada K, Daida H, Aoki S, Giacca A, Kanazawa A, Kawamori R, Watada H.
      Correlates of insulin clearance in apparently healthy non-obese Japanese men.
      Sci Rep. 2017 May 3; 7(1):1462

    • *Hada S, Ishijima M, Kaneko H, Kinoshita M, Liu L, Sadatsuki R, Futami I, Yusup A, Takamura T, Arita H, Shiozawa J, Takazawa Y, Ikeda H, Aoki S, Kurosawa H, Okada Y, Kaneko K: Association of medial meniscal extrusion with medial tibial osteophyte distance detected by T2 mapping MRI in the patients with early-stage knee osteoarthritis.
      Arthritis Res Ther, 19, 201, 2017.

    • *Liu L, Ishijima M, Kaneko H, Sadatsuki R, Hada S, Kinoshita M, Aoki T, Futami I, Yusup A, Takazawa Y, Ikeda H, Kaneko K: The MRI-detected osteophyte score is a predictor for undergoing joint replacement in patients with end-stage knee osteoarthritis.
      Mod Rheumatol, 27, 332-38, 2017.

    • *Sadatsuki R, Ishijima M, Kaneko H, Liu L, Shinnosuke H, Futami I, Kinoshita M, Kubota M, Aoki T, Takazawa Y, Ikeda H, Okada Y, Kaneko K: Bone marrow lesion is associated with disability for activities of daily living in patients with early stage knee osteoarthritis.
      J Bone Miner Metab, 2018 Sep 5. DOI: 10.1007/s00774-018-0950-z.

    • *Furukawa Y, Tamura Y, Takeno K, Funayama T, Kaga H, Suzuki R, Watanabe T, Kakehi S, Kanazawa A, Kawamori R, Watada H.
      Impaired peripheral insulin sensitivity in non-obese Japanese patients with type 2 diabetes mellitus and fatty liver.
      J Diabetes Investig. 2018 May; 9(3): 529-535

    • *Shioya-Yamada M, Shimada K, Nishitani-Yokoyama M, Sai E, Takeno K, Tamura Y, Watada H, Kawamori R, Daida H, Kawai S.
      Association Between Visceral Fat Accumulation and Exercise Tolerance in Non-Obese Subjects Without Diabetes.
      J Clin Med Res. 2018 Aug;10(8):630-635

    • *Isshiki M, Hirayama S, Ueno T, Ito M, Furuta A, Yano K, Yamatani K, Sugihara M, Idei M, Miida T.
      Apolipoproteins C-II and C-III as nutritional markers unaffected by inflammation.
      Clin Chim Acta. 2018 Jun;481: 225-230

    • *Someya Y, Tamura Y, Suzuki R, Kaga H, Kadowaki S, Sugimoto D, Kakehi S, Funayama T, Furukawa Y, Takeno K, Sato J, Kanazawa A, Kawamori R, Watada H.
      Characteristics of Glucose Metabolism in Underweight Japanese Women.
      J Endocr Soc. 2018 Mar 1; 2(3): 279-289

    • *Kadoguchi T, Shimada K, Koide H, Miyazaki T, Shiozawa T, Takahashi S, Aikawa T, Ouchi S, Kitamura K, Sugita Y, Hamad AS, Kunimoto M, Sato-Okabayashi Y, Akita K, Isoda K, Daida H.
      Possible Role of NADPH Oxidase 4 in Angiotensin II-Induced Muscle Wasting in Mice.
      Front Physiol. 2018 Apr 5;9: 340

    • *Eshima H, Tamura Y, Kakehi S, Nakamura K, Kurebayashi N, Murayama T, Kakigi R, Sakurai T, Kawamori R, Watada H．
      Dysfunction of muscle contraction with impaired intracellular Ca(2+) handling in skeletal muscle and the effect of exercise training in male db/db mice．
      J Appl Physiol (1985). 2019 Jan 1;126(1):170-182

    • *Sugimoto D, Tamura Y, Takeno K, Kaga H, Someya Y, Kakehi S, Funayama T, Furukawa Y, Suzuki R, Kadowaki S, Nishitani-Yokoyama M, Shimada K, Daida H, Aoki S, Kanazawa A, Kawamori R, Watada H.
      Clinical Features of Non-obese Apparently Healthy Japanese Men with Reduced Adipose Tissue Insulin Sensitivity.
      J Clin Endocrinol Metab. 2019 Jan 23 [Epub ahead of print]

    • *Osada T, Suzuki R, Ogawa A, Tanaka M, Hori M, Aoki S, Tamura Y, Watada H, Kawamori R, and Konishi S
      Functional subdivisions of the hypothalamus using areal parcellation and their signal changes related to glucose metabolism.
      Neuroimage. 2017 Nov 15;162:1-12

    • *Nishitani-Yokoyama M, Miyauchi K, Shimada K, Yokoyama T, Ouchi S, Aikawa T, Kunimoto M, Yamada M, Honzawa A, Okazaki S, Daida H.
      Impact of physical activity on coronary plaque volume and components in patients with acute coronary syndrome after early-phase II cardiac rehabilitation.
      Circ J. 2018 Dec 25;83(1):101-109

    • *Kunimoto M, Shimada K, Yokoyama M, Matsubara T, Aikawa T, Ouchi S, Shimizu M, Fukao K, Miyazaki T, Kadoguchi T, Fujiwara K, Honzawa A, Yamada M, Shimada A, Yamamoto T, Amano A, Daida H.
      Relationship between the Kihon Checklist and the clinical parameters in patients who participated in cardiac rehabilitation.
      Geriatr Gerontol Int. 2019 Feb 22 [Epub ahead of print]

    文部科学省・ハイテク・リサーチ・センター整備事業における主な業績（平成19～23年度)

    • ①メタボリックシンドローム予防プロジェクト

      • Sato F, Tamura Y, Watada H, Kumashiro N, Igarashi Y, Uchino H, Maehara T, Kyogoku S, Sunayama S, Sato H, Hirose T, Tanaka Y, Kawamori R： Effects of diet-induced moderate weight reduction on intrahepatic and intramyocellular triglycerides and glucose metabolism in obese subjects. J Clin Endocrinol metab 92： 3326-9, 2007

      • Tamura Y, Watada H, Sato F, Kumashiro N, Sakurai Y, Hirose T, Tanaka Y, Kawamori R.： Effects of metformin on peripheral insulin sensitivity and intracellular lipid contents in muscle and liver of overweight Japanese subjects. Diabetes Obes Metab 10： 733-738, 2008.

      • Sakurai Y, Tamura Y, Takeno K, Kumashiro N, Sato F, Kakehi S, Ikeda S, Katamoto S, Ogura Y, Saga N, Naito H, Fujitani Y, Hirose T, Kawamori R, Watada H： Determinants of intramyocellular lipid accumulation after dietary fat loading in non-obese men. Journal of Diabetes Investigation. 4： 310-317, 2011

      • Tamura Y, Watada H, Igarashi Y, Nomiyama T, Onishi T, Takahashi K, Doi S, Katamoto S, Hirose T, Tanaka Y, Kawamori R.： Short-term effects of dietary fat on intramyocellular lipid in sprinters and endurance runners. Metabolism 57： 373-9, 2008.

      • Tamura Y, Watada H, Tanaka Y, Daimaru N, Nomiyama T, Sakuraba K, Sawaki K, Kawamori R.： Preliminary report： mitochondrial DNA 5178 polymorphism in male elite Japanese endurance runners. Metabolism 59： 62-63, 2010.

      • Sakurai Y, Tamura Y, Takeno K, Sato F, Fujitani Y, Hirose T, Kawamori R, Watada H： Association of T2 relaxation time determined by magnetic resonance imaging and intramyocellular lipid content of the soleus muscle in healthy subjects. J Diabetes Inves, 2011 in press.

      • Kawamori R, Tajima N, Iwamoto Y, Kashiwagi A, Shimamoto K, Kaku K.： Voglibose for prevention of type 2 diabetes mellitus： a randomised, double-blind trial in Japanese individuals with impaired glucose tolerance. Lancet 373： 1607-14, 2009.

      • Yamamoto R, Kanazawa A, Shimizu T, Hirose T, Tanaka Y, Kawamori R, Watada H.： Association between atherosclerosis and newly classified chronic kidney disease stage for Japanese patients with type 2 diabetes. Diabetes Res Clin Pract 84： 39-45, 2009.

      • Kasai T, Miyauchi K, Kajimoto K, Kubota N, Kurata T, Amano A, Daida H. The impact of pravastatin therapy on long-term outcome in patients with metabolic syndrome undergoing complete coronary revascularization. Circ J. 73; 2104-9, 2009.

      • Dohi T, Miyauchi K, Kasai T, Kajimoto K, Kubota N, Tamura H, Yokoyama T, Kojima T, Yokoyama K, Kurata T, Daida H. Impact of metabolic syndrome on 10-year clinical outcomes among patients with acute coronary syndrome. Circ J. 73： 1454-8, 2009.

      • Kasai T, Miyauchi K, Kajimoto K, Kubota N, Yanagisawa N, Amano A, Daida H. Relationship between the metabolic syndrome and the incidence of stroke after complete coronary revascularization over a 10-year follow-up period. Atherosclerosis. 207： 195-9, 2009.

      • Kajimoto K, Miyauchi K, Kasai T, Yanagisawa N, Yamamoto T, Kikuchi K, Nakatomi T, Iwamura H, Daida H, Amano A. Metabolic syndrome is an independent risk factor for stroke and acute renal failure after coronary artery bypass grafting. J Thorac Cardiovasc Surg. 137： 658-63, 2009.

      • Kasai T, Miyauchi K, Kurata T, Okazaki S, Kajimoto K, Kubota N, Daida H. Impact of Metabolic Syndrome among Patients with and without Diabetes Mellitus on Long-Term Outcomes after Percutaneous Coronary Intervention. Hypertens Res. 31： 235-41, 2008.

      • Kasai T, Miyauchi K, Kajimoto K, Kubota N, Dohi T, Kurata T, Amano A, Daida H. The adverse prognostic significance of the metabolic syndrome with and without hypertension in patients who underwent complete coronary revascularization. J Hypertens. 27： 1017-24, 2009.

      • Onishi T, Shimada K, Sunayama S, Ohmura H, Sumide T, Masaki Y, Fukao K, Nishitani M, Kume A, Sato H, Naito H, Kawai S, Amano A, Daida H . Effects of cardiac rehabilitation in patients with metabolic syndrome after coronary artery bypass grafting. J Cardiol. 53： 381-7, 2009.

      • Nishitani M, Shimada K, Sunayama S, Masaki Y, Kume A, Fukao K, Sai E, Yamashita H, Ohmura H, Onishi T, Shioya M, Sato H, Shimada A, Yamamoto T, Amano A, Daida H. Impact of diabetes on muscle mass, muscle strength, and exercise tolerance in patients after coronary artery bypass grafting. J Cardiol. 2011 in press.

      • Iwabu M, Yamauchi T, Okada-Iwabu M, Sato K, Nakagawa T, Funata M, Yamaguchi M, Namiki S, Nakayama R, Tabata M, Ogata H, Kubota N, Takamoto I, Hayashi YK, Yamauchi N, Waki H, Fukayama M, Nishino I, Tokuyama K, Ueki K, Oike Y, Ishii S, Hirose K, Shimizu T, Touhara K, Kadowaki T. Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1. Nature. 29;464(7293)：1313-9., 2010

      • Kume, A, Miyazaki T, Kitamura Y, Oshida K, Yanagisawa N, Takizawa H, Fujii K, Kiyanagi T, Sumiyoshi K, Ohmura H, Mokuno H, Shimada K, Daida H. High levels of saturated very long-chain fatty acid (hexacosanoic acid; C26：0) in whole blood are associated with metabolic syndrome in Japanese men. Diabetes Res Clin Pract. 80： 259-64, 2008.

      • Yanagisawa N, Shimada K, Miyazaki T, Kume A, Kitamura Y, Sumiyoshi K, Kiyanagi T, Iesaki T, Inoue N, Daida H. Enhanced Production of Nitric Oxide, Reactive Oxygen Species, and Pro-Inflammatory Cytokines in Very Long Chain Saturated Fatty Acid-Accumulated Macrophages. Lipids Health Dis. 7： 48, 2008.

      • Ishikawa S, Ikejima K, Yamagata H, Aoyama T, Kon K, Arai K, Takeda K, Watanabe S： CD1d-restricted natural killer T cells contribute to hepatic inflammation and fibrogenesis in mice. Journal　of　Hepatology 2011. PMID： 21145835

      • Tamura Y, Ogihara T, Uchida T, Ikeda F, Kumashiro N, Nomiyama T, Sato F, Hirose T, Tanaka Y, Mochizuki H, Kawamori R, Watada H： Amelioration of glucose tolerance by hepatic inhibition of nuclear factor kappaB in db/db mice. Diabetologia 50： 131-41, 2007

      • Kumashiro N, Tamura Y, Uchida T, Ogihara T, Fujitani Y, Hirose T, Mochizuki H, Kawamori R, Watada H.： Impact of oxidative stress and peroxisome proliferator-activated receptor gamma coactivator-1alpha in hepatic insulin resistance. Diabetes 57： 2083-91, 2008.

      • Bian L、Nagata S、Asahara T、Rahman S、Ohta T、Yuki K、Wang C、Nomoto K、Yamashiro Y et al： Effects of the continuous intake of probiotic fermented milk that contains Lactobacillus casei strain Shirota on the risk management of long-term inpatients at health service facilities for the elderly. International Journal of Probiotics & Prebiotics 2011（in press）

      • Fukao K, Shimada K, Naito H, Sumiyoshi K, Inoue N, Iesaki T, Kume A, Kiyanagi T, Hiki M, Hirose K, Matsumori R, Ohsaka H, Takahashi Y, Toyoda S, Itoh S, Miyazaki T, Tada N, Daida H. Voluntary Exercise Ameliorates the Progression of Atherosclerotic Lesion Formation via Anti-inflammatory Effects in Apolipoprotein E-Deficient Mice. J Atheroscler Tromb. 17： 1226-1236, 2010.

      • Watanabe M, Shiohara,A., Matsukawa,T, Chiba,M., Wu,J., Iesaki,T. & Okada,T.： Chronic magenesium deficiency decreases tolerance to hypoxia/reoxygenation injury in mouse heart. Life Sci. 88：658-663, 2011.

    • ②自立力保持プロジェクト

      • Sakuraba K, Ishikawa T： Effect of isokinetic resistance training under a condition of restricted blood flow with pressure.Orthop Sci 14： 631-639, 2009.

      • Hohtatsu K, Yamaji K, Yamada R, Oda K, Kageyama M, Kusaoi M, Onuma S, Kawamoto T, Sugimoto K, Sekiya F, Kon T, Ogasawara M, Kempe K, Tsuda H, Takasaki Y： Effect of Various Anticoagulant Agents on Large-Volume Leukocytapheresis Using New Cellsorba CS-180S Filter. Ther Apher Dial. 15(4)： 355-9, 2011.

      • Komatsu M, Waguri S, Koike M, Sou YS, Ueno T, Hara T, Mizushima N, Iwata J, Ezaki J, Murata S, Hamazaki J, Nishito Y, Iemura S, Natsume T, Yanagawa T, Uwayama J, Warabi E, Yoshida H, Ishii T, Kobayashi A, Yamamoto M, Yue Z, Uchiyama Y, Kominami E, Tanaka K： Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell 131： 1149-1163, 2007

      • Komatsu M, Kurokawa H, Waguri S, Taguchi K, Kobayashi A, Ichimura Y, Sou YS, Ueno I, Sakamoto A, Tong KI, Kim M, Nishito Y, Iemura S, Natsume T, Ueno T, Kominami E, Motohashi H, Tanaka K, Yamamoto M： The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. Nat Cell Biol. 12(3)： 213-23, 2010

      • Ezaki J, Matsumoto N, Takeda-Ezaki M, Komatsu M, Takahashi K, Hiraoka Y, Taka H, Fujimura T, Takehana K, Yoshida M, Iwata J, Tanida I, Furuya N, Zheng DM, Tada N, Tanaka K, Kominami E, Ueno T： Liver autophagy contributes to the maintenance of blood glucose and amino acid levels. Autophagy 7： 1-10, 2011

      • Ishijima M, Tsuji K, Rittling SR, Yamashita T, Kurosawa H, Denhardt DT, Nifuji A, Noda M.： Osteopontin is required for mechanical stress-dependent signals to bone marrow cells. J Endocrinol 193： 235-43, 2007.

      • Ogura Y, Naito H, Tsurukawa T, Ichinosek-Sekine N, Saga N, Sugiura T Katamoto S： Microwave　hyperthermia treatment increases heat shock proteins in human skeletal muscle. British Journal of Sports Medicine 41(7)： 453-45, 2007.

      • Ichinoseki-Sekine N, Naito H, Saga N, Ogura Y, Shiraishi M, Giovannini V, Katamoto S： Changes in muscle temperature induced by 434-MHz microwave hyperthermia. British Journal of Sports Medicine 41(7)： 425-429, 2007.

      • Ogura Y, Naito H, Akin S, Ichinoseki-Sekine N, Kurosaka M, Kakigi R, Sugiura T, Powers SK, Katamoto S, Demirel HA： Elevation of body temperature is an essential factor for exercise-increased extracellular heat shock protein 72 level in rat plasma. Am J Physiol Regul Integr Comp Physiol. 294(5)： R1600-R1607, 2008.

      • Kakigi R, Naito H, Ogura Y, Kobayashi H, Saga N, Ichinoseki-Sekine N, Yoshihara T, Katamoto S： Heat stress enhances mTOR signaling after resistance exercise in human skeletal muscle. J Physiol Sci. 61(2)： 131-40, 2011.

      • Yoshimura N, Muraki S, Oka H, Kawaguchi H, Nakamura K, Akune T： Association of knee osteoarthritis with the accumulation of metabolic risk factors such as overweight, hypertension, dyslipidemia, and impaired glucose tolerance in Japanese men and women： the ROAD study. J Rheumatol. 38(5)： 921-30, 2011.

      • Kawasaki T, Kurosawa H, Ikeda H, Takazawa Y, Ishijima M, Kubota M, Kajihara H, Maruyama Y, Kim SG, Kanazawa H, Doi T： Therapeutic home exercise versus intraarticular hyaluronate injection for osteoarthritis of the knee： 6-month prospective randomized open-labeled trial. J Orthop Sci. 14(2)： 182-91, 2009.

      • Kawasaki T, Kurosawa H, Ikeda H, Kim SG, Osawa A, Takazawa Y, Kubota M, Ishijima M： Additive effects of glucosamine or risedronate for the treatment of osteoarthritis of the knee combined with home exercise： a prospective randomized 18-month trial. J Bone Miner Metab 26： 279-87, 2008.

      • Ishijima M, Sakamoto Y, Yamanaka M, Tokita A, Kitahara K, Kaneko H, Kurosawa H： Minimum required vitamin D level for optimal increase in bone mineral density with alendronate treatment in osteoporotic women. Calcified Tissue Int 85： 398-404, 2009.

      • Kubota A, Sakuraba K, Sawaki K, Sumide T, Tamura Y： Prevention of disuse muscular weakness by restriction of blood flow. Med Sci Sports Exerc. 40(3)： 529-34, 2008.

      • Kubota A, Sakuraba K, Koh S, Ogura Y, Tamura Y： Blood flow restriction by low compressive force prevents disuse muscular weakness. J Sci Med Sport. 14(2)： 95-9, 2011.

      • Sumide T, Sakuraba K, Sawaki K, Ohmura H, Tamura Y： Effect of resistance exercise training combined with relatively low vascular occlusion. J Sci Med Sport. 12(1)：107-12, 2009.

    • ③健脳プロジェクト

      • Takahashi T, Takikawa Y, Kawagoe R, Shibuya S, Iwano T, Kitazawa S： Influence of skin blood flow on near-infrared spectroscopy signals measured on the forehead during a verbal fluency task. NeuroImage 57： 991-1002, 2011.

      • Nakano T, Yamamoto Y, Kitajo K, Takahashi T & Kitazawa S： Synchronization of spontaneous eyeblinks while viewing video stories. Proc R Soc B 276： 3635-3644, 2009.

      • Nakano T, Tanaka K, Endo Y, Yamane Y, Yamamoto T, Nakano Y, Ohta H, Kato N & Kitazawa S： Atypical gaze patterns in children and adults with autism spectrum disorders dissociated from developmental changes in gaze behaviour. Proc R Soc B 277： 2935-2943, 2010.

      • Nakano T, Kato N, Kitazawa S： Lack of eyeblink entrainments in autism spectrum disorders. Neuropsychologia 49： 2784-90, 2011.

      • Yukishita T, Lee K, Kim S, Yumoto Y, Kobayashi A, Shirasawa T, Kobayashi H： Age and sex-dependent alterations in heart rate variability： profiling the characteristics of men and women in their 30s. Anti-Aging Medicine 7： 94-100, 2010.

      • Suetake N, Morita Y, Suzuki D, Lee K, Kobayashi H： Evaluation of autonomic nervous system by heart rate variability and differential count of leukocytes in athletes. Health 2： 1191-1198, 2010.

      • Kim S, Yukishita T, Lee K, Yokota S, Nakata K, Suzuki D, Kobayashi H： The Effect of Mild-Pressure Hyperbaric Therapy (Oasis O2) on Fatigue and Oxidative Stress.Health in press 2011.

      • Ju Y, Hua J, Sakamoto K, Ogawa H, Nagaoka I： Glucosamine, a naturally occurring amino monosaccharide modulates LL-37-induced endothelial cell activation. Int J Mol Med 22： 657-662, 2008.

      • Ju Y, Hua J, Sakamoto K, Ogawa H, Nagaoka I： Modulation of TNF-alpha-induced endothelial cell activation by glucosamine, a naturally occurring amino monosaccharide. Int J Mol Med 22： 809-815, 2008.

      • Yoshimura M, Sakamoto K, Tsuruta A, Yamamoto T, Ishida K, Yamaguchi H, Nagaoka I： Evaluation of the effect of glucosamine administration on biomarkers for cartilage and bone metabolism in soccer players. Int J Mol Med 24： 487-494, 2009.

      • Sugaya K, Igarashi M, Kojima Y, Tsubata M, Nagaoka I： Evaluation of the effect of flavangenol on serum lipid peroxide level and development of atherosclerosis in spontaneously hyperlipidemic B6.KOR-Apoeshl mice. Int. J Mol Med 27： 33-38, 2011.

      • Kimura H, Kon N, Furukawa S, Mukaida M, Yamakura F, Matsumoto K, Sone H, and Murakami-Murofushi K： Effect of Endurance Exercise Training on Oxidative Stress in Spontaneously Hypertensive Rats (SHR) after Emergence of Hypertension. Clinical and Experimental Hypertension 32(7)： 407-415, 2010. Epub 2010 Sep 9.

      • Ikeda K, Hiraoka B-Y, Iwai H, Matsumoto T, Shida N, Mineki R, Taka H, Takamori K, Ogawa H and Yamakura F： Detection of 6-nitrotryptophan in proteins by western blot analysis and its application for peroxynitrite-treated PC12 cells. Nitric Oxide：Biology and Chemistry 16： 18-28. 2007.

      • Sasaki R, Uka T： Dynamic readout of behaviorally relevant signals from area MT during task switching. Neuron 62： 147-157, 2009.

      • Sakurai T, Kaneko K, Okuno M, Wada K, Kashiyama T, Shimizu H, Akagi T, Hashikawa T, Nukina N： Membrane microdomain switching： a regulatory mechanism of amyloid precursor protein processing. J Cell Biol 183： 339-352, 2008.

      • Nakano Y, Baba H, Maeshima H, Kitajima A, Sakai Y, Baba K, Suzuki T, Mimura M, Arai H： Executive dysfunction in medicated, remitted state of major depression. J Affect Disord 111(1)： 46-51, 2008 Nov.

      • Kita Y, Baba H, Maeshima H, Nakano Y, Suzuki T, Arai H： Serum amyloid beta protein in young and elderly depression： a pilot study. Psychogeriatrics 9(4)： 180-5, 2009 Dec.

      • Shibata N, Ohnuma T, Baba H, Arai H： No Genetic association between Polymorphisms of Heme Oxygenase 1 and 2 and Alzheimer’s Disease in a Japanese Population. Dement Geriatr Cogn Disord 27： 273-277, 2009.

      • Shibata N, Kuerban B, Komatsu M, Ohnuma T, Baba H, Arai H： Genetic association between CALHM1, 2, and 3 polymorphisms and Alzheimer’s disease in a Japanese population. J Alzheimers Dis 20： 417-21, 2010.

      • Kuerban B, Shibata N, Komatsu M, Ohnuma T, Arai H： Genetic association between PLTP gene polymorphisms and Alzheimer’s disease in a Japanese population. Dement Geriatr Cogn Disord 30(1)： 78-82, 2010.

      • Komatsu M, Shibata N, Kuerban B, Ohnuma T, Baba H, Arai H： Genetic association between clusterin polymorphisms and Alzheimer’s disease in a Japanese population. Psychogeriatrics 11(1)： 14-8, 2011.