難治性疾患・再生医療実用化研究室

業績一覧

【2021】

原著
Nishikai-Yan ST, Kado M, Hagiwara H, Fujimura S, Mizuno H, Tanaka R
MMP9 secreted from mononuclear cell quality and quantity culture mediates STAT3 phosphorylation and fibroblast migration in wounds.
Regen Ther 18: 464-471, 2021

Geeroms M, Fujimura S, Aiba E, Orgun D, Arita K, Kitamura R, Senda D, Mizuno H, Hamdi M, Tanaka R
Quality and quantity-cultured human mononuclear cells improve human fat graft vascularization and survival in an in vivo murine experimental model.
Plast Reconstr Surg 147: 373-385, 2021

Tanaka R, Ito-Hirano R, Fujimura S, Arita K, Hagiwara H, Mita T, Itoh M, Kawaji H, Ogawa T, Watada H, Masuda H, Asahara T, Mizuno H
Ex vivo conditioning of peripheral blood mononuclear cells of diabetic patients promotes vasculogenic wound healing.
Stem Cells Transl Med, 10: 895-909, 2021.

【2020】

原著
水野博司、山下理絵、宮田成章、林 寛子
特定細胞加工物および細胞増殖因子を用いた注入療法の現状調査
日本美容外科学会会報 42: 19-26, 2020

【2019】

原著
Geeroms M, Hamdi M, Hirano R, Hagiwara H, Fujimura S, Mizuno H and Tanaka R
Quality and quantity cultured murine endothelial progenitor cells increase vascularization and decrease fibrosis in the fat graft
Plast Reconstr Surg 143: 744e-455e, 2019

Tanaka R, Umeyama Y, Hagiwara H, Ito-Hirano R, Fujimura S, Mizuno H, Ogawa R.
Keloid patients have higher peripheral blood endothelial progenitor cell counts and CD34+ cells with normal vasculogenic and angiogenic function that overexpress vascular endothelial growth factor and interleukin-8.
Int J Dermatol 58: 1398-1405, 2019

総説
藤村 聡、田中里佳
順天堂大学における細胞調製施設運営の課題と現状
クリーンテクノロジー 29: 5-8, 2019

水野博司
再生医療法と美容医療
「PEPARS」 No. 147 美容医療の安全管理とトラブルシューティング-Ⅱ安全な美容医療を行うための必須事項
編集:大慈弥裕之 2019; 147-155 全日本病院出版会

著書
水野博司
脂肪注入・移植における脂肪精製・処理
「脂肪注入移植術」 編集:淺野裕子、関堂 充 2019; pp14-20 克誠堂出版

【2018】

原著
Tanaka R, Masuda H, Fujimura S, Ito-Hirano R, Arita K, Kakinuma Y, Hagiwara H, Kado M, Hayashi A, Mita T, Ogawa T, Watada H, Mizuno H, Sawada N and Asahara T
Quality-quantity control culture enhances vasculogenesis and wound healing efficacy of human diabetic peripheral blood CD 34+ cells
Stem Cells Transl Med 7: 428-438, 2018

Kado M, Tanaka R, Arita K, Okada K, Hirano R, Fujimura S and Mizuno H
Human peripheral blood mononuclear cells enriched in endothelial progenitor cells via quality and quantity controlled culture accelerate vascularization and wound healing in a porcine wound model
Cell Transplant 27: 1068-1079, 2018

Hagiwara H, Higashibata A, Ogawa S, Kanazawa S, Mizuno H and Tanaka R
Effectiveness of endothelial progenitor cell culture under microgravity for improved angiogenic potential
Sci Rep 8: 14239, 2018

Ohtake T, Kobayashi S, Mochida Y, Ishioka K, Moriya H, Hidaka S, Matsuura R, Sumida M, Katagiri D, Noiri E, Slavin S, Mizuno H and Tanaka R
Human peripheral blood mononuclear cells incubated in vasculogenic conditioning medium dramatically improve ischemia/reperfusion acute kidney injury in mice.
Cell Transplantation 27(3) 520–530, 2018

総説
Tajima S, Tobita M and Mizuno H
Current status of bone regeneration using adipose-derived stem cells
Histol Histopathol 33: 619-627, 2018

福田太郎、田中里佳
難治性四肢潰瘍に対する血管再生治療
血管外科 37(1): 110-114, 2018

田中里佳
再生医療による創傷治癒の未来
WOC Nursing 6(7):26-34, 2018

藤村 聡、田中里佳
難治性四肢潰瘍患者を対象とした次世代の血管・組織再生治療
内分泌・糖尿病・代謝内科 47(1):18-23, 2018

著書
Tajima S, Tobita M and Mizuno H
Bone regeneration with a combination of adipose-derived stem cells and platelet-rich plasma
In「Adipose Derived Stem Cells: Methods and Protocols, Second Edition」Editors: Bunnell BA and Gimble JM 2018; pp261-272, Springer, New York, NY

【2017】

Luo L, Tanaka R, Kanazawa S, Lu F, Yokomizo T and Mizuno H
A synthetic BLT2 agonist accelerates the cutaneous wound healing process in diabetic rats by indirect stimulation of fibroblasts and direct stimulation of keratinocytes
J Diabetes Complications 31: 13-20, 2017

Shingyochi Y, Kanazawa S, Tajima S, Tanaka R, Mizuno H and Tobita M
A low-level carbon dioxide laser promotes fibroblast proliferation and migration through activation of Akt, ERK, and JNK
PLOS ONE 12: e168937, 2017

Nishikai-Yan Shen T, Kanazawa S, Kado M, Okada K, Luo L, Hayashi A, Mizuno H and Tanaka R
Interleukin-6 stimulates Akt and p38 MAPK phosphorylation and fibroblast migration in non-diabetic but not diabetic mice
PLOS ONE 23; 12: e0178232, 2017

Mifuji K, Ishikawa M, Kamei N, Tanaka R, Arita K, Mizuno H, Asahara T, Adachi N and Ochi M
Angiogenic conditioning of peripheral blood mononuclear cells promotes fracture healing
Bone Joint Res 6: 489-498, 2017

Fukui T, Kawaguchi A, Takekoshi S, Miyasaka M, Sumiyoshi H and Tanaka R
Liposome-encapsulated hemoglobin accelerates skin wound healing in diabetic dB/dB mice
Artif Organs 41: 319-326, 2017

Ohtake T, Kobayashi S, Mochida Y, Ishioka K, Moriya H, Hidaka S, Matsuura R, Sumida M, Katagiri D, Noiri E, Slavin S, Mizuno H and Tanaka R
Human peripheral blood mononuclear cells incubated in vasculogenic conditioning medium dramatically improve ischemia/reperfusion acute kidney injury in mice
Cell Transplant 27: 520-530, 2018

総説
Orgun D and Mizuno H
Multipotency and secretome: the mechanisms behind the regenerative potential of adipose-derived stem cells
Plast Aesthet Res 4: 32-40, 2017

田中里佳
血管幹細胞を用いた組織再生医療
日本形成外科学会会誌 37: 173-179, 2017

藤村 聡、田中里佳
患者まで届いている再生医療―難治性四肢潰瘍患者に対する次世代の血管・組織再生治療
再生医療 16: 26-31, 2017

田中里佳
末梢血単核球生体外培養増幅法(QQc法)を用いた血管再生治療
メディカル・サイエンス・ダイジェスト 43: 2-3, 2017

田中里佳
再生医療を利用した先進的創傷治療
PEPARS 126: 30-37, 2017

著書
Mizuno H, Tobita M, Ogawa R, Orbay H, Fujimura J, Ono S, Kakudo N, Kusumoto K and Hyakusoku H
Adipose-derived stem cells in regenerative medicine
In「Principle of gender-specific medicine」Editor: Legato MJ 2017; pp459-479, Elsevier, San Diego, CA

Tajima S, Tobita M and Mizuno H
Bone regeneration with a combination of adipose-derived stem cells and platelet-rich plasma
In「Adipose Derived Stem Cells: Methods and Protocols, Second Edition」Editors: Bunnell BA and Gimble JM 2018; pp261-272, Springer, New York, NY

田中里佳
再生医療 
「フットケア診療の手引き」編集:日本フットケア学会、医学書院 204-208, 2017

【2016】

原著
Horikoshi-Ishihara H, Tobita M, Tajima S, Tanaka R, Oshita T, Tabata Y and Mizuno H
Co-administration of adipose-derived stem cells and control-released basic fibroblast growth factor facilitates angiogenesis in a murine ischemic hind limb model
J Vasc Surg 64: 1825-1834, 2016

Huang C, Orbay H, Tobita M, Miyamoto M, Tabata Y, Hyakusoku H and Mizuno H
Pro-apoptotic effect of control-released basic fibroblast growth factor on skin wound healing in a diabetic mouse model
Wound Repair Regen 24: 65-74, 2016

Oshita T, Tobita M, Tajima S and Mizuno H
Adipose-derived stem cells improve collagenase-induced tendinopathy in a rat model
Am J Sports Med 44: 1983-1989, 2016

著書
Mizuno H, Tobita M, Orbay H, Uysal AC and Lu F
Adipose-derived stem cells as a novel tool for future regenerative medicine
In「Stem Cells and Cancer Stem Cells」
Editor: Hayat MA, Springer, New York, NY in press

Tajima S, Tobita M and Mizuno H
Bone regeneration with a combination of adipose-derived stem cells and platelet-rich plasma
In「Adipose Derived Stem Cells: Methods and Protocols, Second Edition」
Editors: Bunnell BA and Gimble JM, Springer, New York, NY