【最近の研究成果（2015〜）】

2023年

1.  Mitsui S, Yamaguchi J, Suzuki C, Uchiyama Y, Tanida I: TUNEL-positive structures in activated microglia and SQSTM1/p62-positive structures in activated astrocytes in the neurodegenerative brain of a CLN10 mouse model. Glia. 2023 Aug 12. doi: 10.1002/glia.24449 プレスリリース

2. Tanida I, Yamaguchi J, Suzuki C, Kakuta S, Uchiyama Y: Application of immuno- and affinity labeling with fluorescent dyes to in-resin CLEM of Epon-embedded cells. Heliyon. 2023;9(6):e17394. doi: 10.1016/j.heliyon.2023.e17394. eCollection 2023 Jun. PMID: 37389060 プレスリリース

3. Okuzumi A, Hatano T, Matsumoto G, Nojiri S, Ueno SI, Imamichi-Tatano Y, Kimura H, Kakuta S, Kondo A, Fukuhara T, Li Y, Funayama M, Saiki S, Taniguchi D, Tsunemi T, McIntyre D, Gérardy JJ, Mittelbronn M, Kruger R, Uchiyama Y, Nukina N, Hattori N: Propagative α-synuclein seeds as serum biomarkers for synucleinopathies. Nat Med. 2023;29(6):1448-1455. doi: 10.1038/s41591-023-02358-9.

4. Tanida I, Yamaguchi J, Suzuki C, Kakuta S, Uchiyama Y: Recent advances in in-resin correlative light and electron microscopy of Epon-embedded cells. Microscopy (Oxf). 2023:dfad028. doi: 10.1093/jmicro/dfad028. Online ahead of print. PMID: 37217182

5. Tanida I, Yamaguchi J, Kakuta S, Uchiyama Y: Osmium-Resistant Fluorescent Proteins and In-Resin Correlative Light-Electron Microscopy of Epon-Embedded Mammalian Cultured Cells. Methods Mol Biol. 2023;2564:287-297. doi: 10.1007/978-1-0716-2667-2_15.

5. Miyakawa M, Murakmai S, Uchiyama Y: Wide-ranging migration and destination of early olfactory placode-derived neurons in chick embryos. Anat Rec (Hoboken). 2023 Feb;306(2):298-310. doi: 10.1002/ar.25080.

2022年

1. Huyghe J, Priem D, Van Hove L, Gilbert B, Fritsch J, Uchiyama Y, Hoste E, van Loo G, Bertrand MJM: ATG9A prevents TNF cytotoxicity by an unconventional lysosomal targeting pathway. Science. 2022, 378:1201-1207.

2. Sou YS, Yamaguchi J, Kameda H, Masuda K, Maeda Y, Uchiyama Y, Koike M: GPHR-mediated acidification of the Golgi lumen is essential for cholesterol biosynthesis in the brain. FEBS Lett. 2022, 596:2873-2888.

3. Murakami S, Ohki-Hamazaki H, Uchiyama Y: Olfactory placode generates a diverse population of neurons expressing GnRH, somatostatin mRNA, neuropeptide Y, or calbindin in the chick forebrain. J Comp Neurol. 2022, 530:2977-2993.

4. Suzuki C, Yamaguchi J, Sanada T, Oliva Trejo JA, Kakuta S, Shibata M, Tanida I, Uchiyama Y: Lack of Cathepsin D in the central nervous system results in microglia and astrocyte activation and the accumulation of proteinopathy-related proteins. Sci Rep. 2022, 12:11662.　プレスリリース

5. Sanada T, Yamaguchi J, Furuta Y, Kakuta S, Tanida I, Uchiyama Y: In-resin CLEM of Epon-embedded cells using proximity labeling. Sci Rep. 2022, 12:11130. プレスリリース

6. Ochiai Y, Suzuki C, Segawa K, Uchiyama Y, Nagata S: Inefficient development of syncytiotrophoblasts in the Atp11a-deficient mouse placenta. Proc Natl Acad Sci U S A. 2022, 119:e2200582119.

7. Suzuki A, Iwaya C, Ogata K, Yoshioka H, Shim J, Tanida I, Komatsu M, Tada N, Iwata J: Impaired GATE16-mediated exocytosis in exocrine tissues causes Sjögren’s syndrome-like exocrinopathy. Cell Mol Life Sci. 2022, 79:307.

8. Shichinohe T, Kondo T, Date H, Hiramatsu M, Hirano S, Ide C, Iwanaga T, Izawa Y, Kikuta A, Kobayashi E, Matsui Y, Nohara Y, Shibata T, Shirakawa Y, Suzuki T, Takahashi H, Taneichi H, Tsurumoto T, Uchiyama Y, Watanabe M, Yaginuma H, Yamaguchi K, Yoshida K: Guidelines for cadaver dissection in education and research of clinical medicine (The Japan Surgical Society and The Japanese Association of Anatomists). Anat Sci Int. 2022, 97(3):235-240.

9. Shichinohe T, Kondo T, Date H, Hiramatsu M, Hirano S, Ide C, Iwanaga T, Izawa Y, Kikuta A, Kobayashi E, Matsui Y, Nohara Y, Shibata T, Shirakawa Y, Suzuki T, Takahashi H, Taneichi H, Tsurumoto T, Uchiyama Y, Watanabe M, Yaginuma H, Yamaguchi K, Yoshida K: Guidelines for cadaver dissection in education and research of clinical medicine (The Japan Surgical Society and The Japanese Association of Anatomists). Surg Today. 2022, 52(7):989-994.

和文原著

1. 谷田以誠, 山口隼司, 角田宗一郎, 内山安男、エポン樹脂包埋試料中の蛍光タンパク質を観察する ～In-resin CLEMへのアプローチ、解剖学雑誌 2022, 97:13-16.

2. 内山安男、リソソームカテプシン　分布と役割、生体の科学 2022, 73:191-195.

2021年

1: Tanida I, Haruta T, Suga M, Takei S, Takebe A, Furuta Y, Yamaguchi J, Oliva Trejo JA, Kakuta S, Uchiyama Y. Membranous Structures Directly Come in Contact With p62/SQSTM1 Bodies. J Histochem Cytochem. 2021 Apr 22:221554211011423. doi: 10.1369/00221554211011423. PMID: 33884901

2: Maruyama K, Yoneda K, Sugita S, Yamamoto Y, Koike M, Peters C, Uchiyama Y, Nishida K. CTLA-2 Alpha Is a Potent Inhibitor of Angiogenesis in Murine Ocular Tissue. Antioxidants (Basel). 2021 Mar 15;10(3):456. doi: 10.3390/antiox10030456. PMID: 33804126

3: Iwama H, Mehanna S, Imasaka M, Hashidume S, Nishiura H, Yamamura KI, Suzuki C, Uchiyama Y, Hatano E, Ohmuraya M. Cathepsin B and D deficiency in the mouse pancreas induces impaired autophagy and chronic pancreatitis. Sci Rep. 2021 Mar 23;11(1):6596. doi: 10.1038/s41598-021-85898-9. PMID: 33758261

4: Watanabe K, Morishita K, Zhou X, Shiizaki S, Uchiyama Y, Koike M, Naguro I, Ichijo H. Cells recognize osmotic stress through liquid-liquid phase separation lubricated with poly(ADP-ribose). Nat Commun. 2021 Mar 1;12(1):1353. doi: 10.1038/s41467-021-21614-5. PMID: 33649309

5: Klionsky DJ, Tanida I, Uchiyama Y, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1. Autophagy. 2021 Jan;17(1):1-382. doi: 10.1080/15548627.2020.1797280. Epub 2021 Feb 8. PMID: 33634751

6: Sato S, Noda S, Torii S, Amo T, Ikeda A, Funayama M, Yamaguchi J, Fukuda T, Kondo H, Tada N, Arakawa S, Watanabe M, Uchiyama Y, Shimizu S, Hattori N. Homeostatic p62 levels and inclusion body formation in CHCHD2 knockout mice. Hum Mol Genet. 2021 Apr 30;30(6):443-453. doi: 10.1093/hmg/ddab057. PMID: 33631794

2020年

1: Tanida I, Furuta Y, Yamaguchi J, Kakuta S, Oliva Trejo JA, Uchiyama Y. Two-color in-resin CLEM of Epon-embedded cells using osmium resistant green and red fluorescent proteins. Sci Rep. 2020 Dec 14;10(1):21871. doi: 10.1038/s41598-020-78879-x. PMID: 33318540 プレスリリース

2: Nagai N, Kawashima H, Toda E, Homma K, Osada H, Guzman NA, Shibata S, Uchiyama Y, Okano H, Tsubota K, Ozawa Y. Renin-angiotensin system impairs macrophage lipid metabolism to promote age-related macular degeneration in mouse models. Commun Biol. 2020 Dec 9;3(1):767. doi: 10.1038/s42003-020-01483-2. PMID: 33299105

3: Ogawa M, Shirasago Y, Tanida I, Kakuta S, Uchiyama Y, Shimojima M, Hanada K, Saijo M, Fukasawa M. Structural basis of antiviral activity of caffeic acid against severe fever with thrombocytopenia syndrome virus. J Infect Chemother. 2021 Feb;27(2):397-400. doi: 10.1016/j.jiac.2020.10.015. Epub 2020 Oct 24. PMID: 3310943

4: Yoshino S, Iwasaki Y, Matsumoto S, Satoh T, Ozawa A, Yamada E, Kakizaki S, Trejo JAO, Uchiyama Y, Yamada M, Mori M. Administration of small-molecule guanabenz acetate attenuates fatty liver and hyperglycemia associated with obesity. Sci Rep. 2020 Aug 13;10(1):13671. doi: 10.1038/s41598-020-70689-5. PMID: 32792584

5: Tanida I, Kakuta S, Oliva Trejo JA, Uchiyama Y. Visualization of cytoplasmic organelles via in-resin CLEM using an osmium-resistant far-red protein. Sci Rep. 2020 Jul 9;10(1):11314. doi: 10.1038/s41598-020-68191-z. PMID: 32647231　プレスリリース

6: Oliva Trejo JA, Tanida I, Suzuki C, Kakuta S, Tada N, Uchiyama Y. Characterization of starvation-induced autophagy in cerebellar Purkinje cells of pHluorin-mKate2-human LC3B transgenic mice. Sci Rep. 2020 Jun 15;10(1):9643. doi: 10.1038/s41598-020-66370-6. PMID: 32541814; PMCID: PMC7295967　プレスリリース

7: Miyake S, Murai S, Kakuta S, Uchiyama Y, Nakano H. Identification of the hallmarks of necroptosis and ferroptosis by transmission electron microscopy. Biochem Biophys Res Commun. 2020 Jun 30;527(3):839-844. doi: 10.1016/j.bbrc.2020.04.127. Epub 2020 May 16. PMID: 32430176.

8: Morimoto K, Suzuki N, Tanida I, Kakuta S, Furuta Y, Uchiyama Y, Hanada K, Suzuki Y, Yamaji T. Blood group P1 antigen-bearing glycoproteins are functional but less efficient receptors of Shiga toxin than conventional glycolipid-based receptors. J Biol Chem. 2020 May 14:jbc.RA120.013926. doi: 10.1074/jbc.RA120.013926. PMID: 32409578.

9: Oji Y, Hatano T, Ueno SI, Funayama M, Ishikawa KI, Okuzumi A, Noda S, Sato S, Satake W, Toda T, Li Y, Hino-Takai T, Kakuta S, Tsunemi T, Yoshino H, Nishioka K, Hattori T, Mizutani Y, Mutoh T, Yokochi F, Ichinose Y, Koh K, Shindo K, Takiyama Y, Hamaguchi T, Yamada M, Farrer MJ, Uchiyama Y, Akamatsu W, Wu YR, Matsuda J, Hattori N. Variants in saposin D domain of prosaposin gene linked to Parkinson’s disease. Brain. 2020 Apr 1;143(4):1190-1205. doi: 10.1093/brain/awaa064. PMID: 32201884.

10: Lüningschrör P, Werner G, Stroobants S, Kakuta S, Dombert B, Sinske D, Wanner R, Lüllmann-Rauch R, Wefers B, Wurst W, D’Hooge R, Uchiyama Y, Sendtner M, Haass C, Saftig P, Knöll B, Capell A, Damme M. The FTLD Risk Factor TMEM106B Regulates the Transport of Lysosomes at the Axon Initial Segment of Motoneurons. Cell Rep. 2020 Mar 10;30(10):3506-3519.e6. doi: 10.1016/j.celrep.2020.02.060. PMID: 32160553.

11: Ozawa K, Tsumoto H, Miura Y, Yamaguchi J, Iguchi-Ariga SMM, Sakuma T, Yamamoto T, Uchiyama Y. DJ-1 is indispensable for the S-nitrosylation of Parkin, which maintains function of mitochondria. Sci Rep. 2020 Mar 9;10(1):4377. doi: 10.1038/s41598-020-61287-6. PMID: 32152416; PMCID: PMC7062835.

2019年

1: Suzuki C, Tanida I, Oliva Trejo JA, Kakuta S, Uchiyama Y. Autophagy Deficiency in Renal Proximal Tubular Cells Leads to an Increase in Cellular Injury and Apoptosis under Normal Fed Conditions. Int J Mol Sci. 2019 Dec 25;21(1):155. doi: 10.3390/ijms21010155. PMID: 31881660; PMCID: PMC6982095.

2: Noda S, Sato S, Fukuda T, Tada N, Uchiyama Y, Tanaka K, Hattori N. Loss of Parkin contributes to mitochondrial turnover and dopaminergic neuronal loss in aged mice. Neurobiol Dis. 2020 Mar;136:104717. doi: 10.1016/j.nbd.2019.104717. Epub 2019 Dec 15. PMID: 31846738.

3: Yamashita Y, Suzuki C, Uchiyama Y, Nagata S. Infertility Caused by Inefficient Apoptotic Germ Cell Clearance in Xkr8-Deficient Male Mice. Mol Cell Biol. 2020 Jan 16;40(3):e00402-19. doi: 10.1128/MCB.00402-19. PMID: 31712393; PMCID: PMC6965033.

4: Shindo R, Ohmuraya M, Komazawa-Sakon S, Miyake S, Deguchi Y, Yamazaki S, Nishina T, Yoshimoto T, Kakuta S, Koike M, Uchiyama Y, Konishi H, Kiyama H, Mikami T, Moriwaki K, Araki K, Nakano H. Necroptosis of Intestinal Epithelial Cells Induces Type 3 Innate Lymphoid Cell-Dependent Lethal Ileitis. iScience. 2019 May 31;15:536-551. doi: 10.1016/j.isci.2019.05.011. Epub 2019 May 14. PMID: 31132747; PMCID: PMC6538961.

5: Sou YS, Kakuta S, Kamikubo Y, Niisato K, Sakurai T, Parajuli LK, Tanida I, Saito H, Suzuki N, Sakimura K, Maeda Y, Kinoshita T, Uchiyama Y, Koike M. Cerebellar Neurodegeneration and Neuronal Circuit Remodeling in Golgi pH Regulator-Deficient Mice. eNeuro. 2019 May 29;6(3):ENEURO.0427-18.2019. doi: 10.1523/ENEURO.0427-18.2019. PMID: 31118204; PMCID: PMC6541875.

6: Suzuki C, Tanida I, Ohmuraya M, Oliva Trejo JA, Kakuta S, Sunabori T, Uchiyama Y. Lack of Cathepsin D in the Renal Proximal Tubular Cells Resulted in Increased Sensitivity against Renal Ischemia/Reperfusion Injury. Int J Mol Sci. 2019 Apr 5;20(7):1711. doi: 10.3390/ijms20071711. PMID: 30959855; PMCID: PMC6479628.

2018年

1: Segawa K, Yanagihashi Y, Yamada K, Suzuki C, Uchiyama Y, Nagata S. Phospholipid flippases enable precursor B cells to flee engulfment by macrophages. Proc Natl Acad Sci U S A. 2018 Nov 27;115(48):12212-12217. doi: 10.1073/pnas.1814323115. Epub 2018 Oct 24. PMID: 30355768; PMCID: PMC6275493.

2: Shimada Y, Shimura H, Tanaka R, Yamashiro K, Koike M, Uchiyama Y, Urabe T, Hattori N. Phosphorylated recombinant HSP27 protects the brain and attenuates blood-brain barrier disruption following stroke in mice receiving intravenous tissue-plasminogen activator. PLoS One. 2018 May 24;13(5):e0198039. doi: 10.1371/journal.pone.0198039. PMID: 29795667; PMCID: PMC5993064.

3: Ogawa Y, Yamaguchi J, Yano M, Uchiyama Y, Okano HJ. Elavl3 regulates neuronal polarity through the alternative splicing of an embryo-specific exon in AnkyrinG. Neurosci Res. 2018 Oct;135:13-20. doi: 10.1016/j.neures.2018.03.008. Epub 2018 Mar 31. PMID: 29614249.

4: Piao X, Miura R, Miyake S, Komazawa-Sakon S, Koike M, Shindo R, Takeda J, Hasegawa A, Abe R, Nishiyama C, Mikami T, Yagita H, Uchiyama Y, Nakano H. Blockade of TNF receptor superfamily 1 (TNFR1)-dependent and TNFR1-independent cell death is crucial for normal epidermal differentiation. J Allergy Clin Immunol. 2019 Jan;143(1):213-228.e10. doi: 10.1016/j.jaci.2018.02.043. Epub 2018 Mar 27. PMID: 29596938.

5: Komine O, Yamashita H, Fujimori-Tonou N, Koike M, Jin S, Moriwaki Y, Endo F, Watanabe S, Uematsu S, Akira S, Uchiyama Y, Takahashi R, Misawa H, Yamanaka K. Innate immune adaptor TRIF deficiency accelerates disease progression of ALS mice with accumulation of aberrantly activated astrocytes. Cell Death Differ. 2018 Dec;25(12):2130-2146. doi: 10.1038/s41418-018-0098-3. Epub 2018 Mar 22. PMID: 29568058; PMCID: PMC6261996.

6: Sato S, Uchihara T, Fukuda T, Noda S, Kondo H, Saiki S, Komatsu M, Uchiyama Y, Tanaka K, Hattori N. Loss of autophagy in dopaminergic neurons causes Lewy pathology and motor dysfunction in aged mice. Sci Rep. 2018 Feb 12;8(1):2813. doi: 10.1038/s41598-018-21325-w. PMID: 29434298; PMCID: PMC5809579.

7: Ogawa Y, Kakumoto K, Yoshida T, Kuwako KI, Miyazaki T, Yamaguchi J, Konno A, Hata J, Uchiyama Y, Hirai H, Watanabe M, Darnell RB, Okano H, Okano HJ. Elavl3 is essential for the maintenance of Purkinje neuron axons. Sci Rep. 2018 Feb 9;8(1):2722. doi: 10.1038/s41598-018-21130-5. PMID: 29426875; PMCID: PMC5807307.

8: Tanida-Miyake E, Koike M, Uchiyama Y, Tanida I. Optimization of mNeonGreen for Homo sapiens increases its fluorescent intensity in mammalian cells. PLoS One. 2018 Jan 17;13(1):e0191108. doi: 10.1371/journal.pone.0191108. PMID: 29342181; PMCID: PMC5771595.

2017年

1: Takakura K, Ito S, Sonoda J, Tabata K, Shiozaki M, Nagai K, Shibata M, Koike M, Uchiyama Y, Gotow T. Cordyceps militaris improves the survival of Dahl salt-sensitive hypertensive rats possibly via influences of mitochondria and autophagy functions. Heliyon. 2017 Nov 24;3(11):e00462. doi: 10.1016/j.heliyon.2017.e00462. PMID: 29264419; PMCID: PMC5727564.

2: Kakuta S, Yamaguchi J, Suzuki C, Sasaki M, Kazuno S, Uchiyama Y. Small GTPase Rab1B is associated with ATG9A vesicles and regulates autophagosome formation. FASEB J. 2017 Sep;31(9):3757-3773. doi: 10.1096/fj.201601052R. PMID: 28522593.

3: Yamaguchi J, Suzuki C, Nanao T, Kakuta S, Ozawa K, Tanida I, Saitoh T, Sunabori T, Komatsu M, Tanaka K, Aoki S, Sakimura K, Uchiyama Y. Atg9a deficiency causes axon-specific lesions including neuronal circuit dysgenesis. Autophagy. 2018;14(5):764-777. doi: 10.1080/15548627.2017.1314897. Epub 2018 Mar 6. PMID: 28513333; PMCID: PMC6070006.

4: Koike M, Shibata M, Sunabori T, Yamaguchi J, Sakimura K, Komatsu M, Tanaka K, Uchiyama Y. Purkinje Cells Are More Vulnerable to the Specific Depletion of Cathepsin D Than to That of Atg7. Am J Pathol. 2017 Jul;187(7):1586-1600. doi: 10.1016/j.ajpath.2017.02.020. PMID: 28502476.

5: Ishimoto T, Ninomiya K, Inoue R, Koike M, Uchiyama Y, Mori H. Mice lacking BCAS1, a novel myelin-associated protein, display hypomyelination, schizophrenia-like abnormal behaviors, and upregulation of inflammatory genes in the brain. Glia. 2017 May;65(5):727-739. doi: 10.1002/glia.23129. PMID: 28230289.

2016年

1: Sakata K, Araki K, Nakano H, Nishina T, Komazawa-Sakon S, Murai S, Lee GE, Hashimoto D, Suzuki C, Uchiyama Y, Notohara K, Gukovskaya AS, Gukovsky I, Yamamura KI, Baba H, Ohmuraya M. Novel method to rescue a lethal phenotype through integration of target gene onto the X-chromosome. Sci Rep. 2016 Nov 15;6:37200. doi: 10.1038/srep37200. PMID: 27845447; PMCID: PMC5109027.

2 Sato S, Koike M, Funayama M, Ezaki J, Fukuda T, Ueno T, Uchiyama Y, Hattori N. Lysosomal Storage of Subunit c of Mitochondrial ATP Synthase in Brain- Specific Atp13a2-Deficient Mice. Am J Pathol. 2016 Dec;186(12):3074-3082. doi: 10.1016/j.ajpath.2016.08.006. Epub 2016 Oct 19. PMID: 27770614.

3: Piao X, Yamazaki S, Komazawa-Sakon S, Miyake S, Nakabayashi O, Kurosawa T, Mikami T, Tanaka M, Van Rooijen N, Ohmuraya M, Oikawa A, Kojima Y, Kakuta S, Uchiyama Y, Tanaka M, Nakano H. Depletion of myeloid cells exacerbates hepatitis and induces an aberrant increase in histone H3 in mouse serum. Hepatology. 2017 Jan;65(1):237-252. doi: 10.1002/hep.28878. Epub 2016 Nov 25. PMID: 27770461.

4: Yamanaka T, Tosaki A, Miyazaki H, Kurosawa M, Koike M, Uchiyama Y, Maity SN, Misawa H, Takahashi R, Shimogori T, Hattori N, Nukina N. Differential roles of NF-Y transcription factor in ER chaperone expression and neuronal maintenance in the CNS. Sci Rep. 2016 Sep 30;6:34575. doi: 10.1038/srep34575. PMID: 27687130; PMCID: PMC5043352.

5: Hadano S, Mitsui S, Pan L, Otomo A, Kubo M, Sato K, Ono S, Onodera W, Abe K, Chen X, Koike M, Uchiyama Y, Aoki M, Warabi E, Yamamoto M, Ishii T, Yanagawa T, Shang HF, Yoshii F. Functional links between SQSTM1 and ALS2 in the pathogenesis of ALS: cumulative impact on the protection against mutant SOD1-mediated motor dysfunction in mice. Hum Mol Genet. 2016 Aug 1;25(15):3321-3340. doi: 10.1093/hmg/ddw180.  PMID: 27439389.

6: Sunabori T, Koike M, Asari A, Oonuki Y, Uchiyama Y. Suppression of Ischemia- Induced Hippocampal Pyramidal Neuron Death by Hyaluronan Tetrasaccharide through Inhibition of Toll-Like Receptor 2 Signaling Pathway. Am J Pathol. 2016 Aug;186(8):2143-2151. doi: 10.1016/j.ajpath.2016.03.016.  PMID: 27301359.

7: Sekine S, Yao A, Hattori K, Sugawara S, Naguro I, Koike M, Uchiyama Y, Takeda K, Ichijo H. The Ablation of Mitochondrial Protein Phosphatase Pgam5 Confers Resistance Against Metabolic Stress. EBioMedicine. 2016 Jan 29;5:82-92. doi: 10.1016/j.ebiom.2016.01.031. PMID: 27077115; PMCID: PMC4816851.

8: Yamamoto-Nonaka K, Koike M, Asanuma K, Takagi M, Oliva Trejo JA, Seki T, Hidaka T, Ichimura K, Sakai T, Tada N, Ueno T, Uchiyama Y, Tomino Y. Cathepsin D in Podocytes Is Important in the Pathogenesis of Proteinuria and CKD. J Am Soc Nephrol. 2016 Sep;27(9):2685-700. doi: 10.1681/ASN.2015040366. Epub 2016 Jan 28. PMID: 26823550; PMCID: PMC5004641.

9: Klionsky DJ, Tanida I, Uchiyama Y. et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12(1):1-222. doi: 10.1080/15548627.2015.1100356. Erratum in: Autophagy. 2016;12(2):443. Selliez, Iban [corrected to Seiliez, Iban]. PMID: 26799652; PMCID: PMC4835977.

10: Xie C, Ginet V, Sun Y, Koike M, Zhou K, Li T, Li H, Li Q, Wang X, Uchiyama Y, Truttmann AC, Kroemer G, Puyal J, Blomgren K, Zhu C. Neuroprotection by selective neuronal deletion of Atg7 in neonatal brain injury. Autophagy. 2016;12(2):410-23. doi: 10.1080/15548627.2015.1132134. PMID: 26727396; PMCID: PMC4835980.

2015年

1: Mehanna S, Suzuki C, Shibata M, Sunabori T, Imanaka T, Araki K, Yamamura K, Uchiyama Y, Ohmuraya M. Cathepsin D in pancreatic acinar cells is implicated in cathepsin B and L degradation, but not in autophagic activity. Biochem Biophys Res Commun. 2016 Jan 15;469(3):405-11. doi: 10.1016/j.bbrc.2015.12.002. Epub 2015 Dec 9. PMID: 26682926.

2: Furuta A, Kikuchi H, Fujita H, Yamada D, Fujiwara Y, Kabuta T, Nishino I, Wada K, Uchiyama Y. Property of lysosomal storage disease associated with midbrain pathology in the central nervous system of Lamp-2-deficient mice. Am J Pathol. 2015 Jun;185(6):1713-23. doi: 10.1016/j.ajpath.2015.02.015. PMID: 25998250.

3: Rinchai D, Riyapa D, Buddhisa S, Utispan K, Titball RW, Stevens MP, Stevens JM, Ogawa M, Tanida I, Koike M, Uchiyama Y, Ato M, Lertmemongkolchai G. Macroautophagy is essential for killing of intracellular Burkholderia pseudomallei in human neutrophils. Autophagy. 2015;11(5):748-55. doi: 10.1080/15548627.2015.1040969. PMID: 25996656; PMCID: PMC4509438.

4: Nanao T, Koike M, Yamaguchi J, Sasaki M, Uchiyama Y. Cellular localization and tissue distribution of endogenous DFCP1 protein. Biomed Res. 2015;36(2):121-33. doi: 10.2220/biomedres.36.121. PMID: 25876663.

5: Uemura N, Koike M, Ansai S, Kinoshita M, Ishikawa-Fujiwara T, Matsui H, Naruse K, Sakamoto N, Uchiyama Y, Todo T, Takeda S, Yamakado H, Takahashi R. Viable neuronopathic Gaucher disease model in Medaka (Oryzias latipes) displays axonal accumulation of alpha-synuclein. PLoS Genet. 2015 Apr 2;11(4):e1005065. doi: 10.1371/journal.pgen.1005065. PMID: 25835295; PMCID: PMC4383526.

6: Nori S, Okada Y, Nishimura S, Sasaki T, Itakura G, Kobayashi Y, Renault- Mihara F, Shimizu A, Koya I, Yoshida R, Kudoh J, Koike M, Uchiyama Y, Ikeda E, Toyama Y, Nakamura M, Okano H. Long-term safety issues of iPSC-based cell therapy in a spinal cord injury model: oncogenic transformation with epithelial- mesenchymal transition. Stem Cell Reports. 2015 Mar 10;4(3):360-73. doi: 10.1016/j.stemcr.2015.01.006. Epub 2015 Feb 13. PMID: 25684226; PMCID: PMC4375796.

7: Funayama M, Ohe K, Amo T, Furuya N, Yamaguchi J, Saiki S, Li Y, Ogaki K, Ando M, Yoshino H, Tomiyama H, Nishioka K, Hasegawa K, Saiki H, Satake W, Mogushi K, Sasaki R, Kokubo Y, Kuzuhara S, Toda T, Mizuno Y, Uchiyama Y, Ohno K, Hattori N. CHCHD2 mutations in autosomal dominant late-onset Parkinson’s disease: a genome-wide linkage and sequencing study. Lancet Neurol. 2015 Mar;14(3):274-82. doi: 10.1016/S1474-4422(14)70266-2. Epub 2015 Feb 4. PMID: 25662902.