論文発表
2021年
Inomata T, Nakamura M, Sung J, Midorikawa-Inomata A, Iwagami M, Fujio K, Akasaki Y, Okumura Y, Fujimoto K, Eguchi A, Miura M, Nagino K, Shokirova H, Zhu J, Kuwahara M, Hirosawa K, Dana R, Murakami A.
Smartphone-based digital phenotyping for dry eye toward P4 medicine: a crowdsourced cross-sectional study.
ドライアイ研究用スマホアプリ「ドライアイリズム®」を用いたドライアイに対するデジタルフェノタイピングによるP4医療の実現
npj digital medicine 4: Article number171, 2021
Shuji Sawada, Hayao
Ozaki, Toshiharu Natsume, Daiki Nakano, Pengyu Deng, Toshinori Yoshihara, Takuya Osawa,
Hiroyuki Kobayashi, Shuichi Machida, Hisashi Naito.
Serum albumin levels as a predictive biomarker for low-load resistance training
programs' effects on muscle thickness in the community-dwelling elderly Japanese
population: interventional study result.
血清アルブミン値は高齢日本人の低負荷レジスタンストレーニングプログラムの筋厚への影響を予測するバイオマーカー:地域に住む高齢者を対象とした介入研究結果
BMC geriatrics 21(1):464-464, 2021.
Shuji Sawada, Hayao
Ozaki, Toshiharu Natsume, Pengyu Deng, Toshinori Yoshihara, Takashi Nakagata, Takuya
Osawa, Yoshihiko Ishihara, Tomoharu Kitada, Ken Kimura, Nobuhiro Sato, Shuichi Machida,
Hisashi Naito.
The 30-s chair stand test can be a useful tool for screening sarcopenia in elderly
Japanese participants.
30秒椅子立ちテストは、高齢日本人のサルコペニアをスクリーニングするための有用なツール
BMC musculoskeletal disorders 22(1):639-639, 2021.
Toshiharu Natsume, Hayao
Ozaki, Takashi Nakagata, Toshinori Yoshihara, Tomoharu Kitada, Yoshihiko Ishihara,
Pengyu Deng, Takuya Osawa, Shuji Sawada, Hiroyuki Kobayashi, Shuich Machida, Hisashi
Naito.
Site-Specific Muscle Loss in the Abdomen and Anterior Thigh in Elderly Males with
Locomotive Syndrome.
ロコモティブシンドロームの高齢男性における腹部および大腿部前部の部位別の筋力低下
Journal of sports science and medicine 20(4):635-641, 2021.
2020年
Satoshi Nakada, Yuri
Yamashita, Shuichi Machida, Yuko Miyagoe-Suzuki, Eri Arikawa-Hirasawa.
Perlecan Facilitates Neuronal Nitric Oxide Synthase Delocalization in
Denervation-Induced Muscle Atrophy.
パールカンは除神経性筋萎縮における神経性一酸化窒素合成酵素の局在化を促進する
Cells 9(11):2524, 2020.
Hayao Ozaki, Shuji Sawada, Takuya Osawa, Toshiharu Natsume, Toshinori Yoshihara, Pengyu
Deng, Shuichi Machida, Hisashi Naito.
Muscle Size and Strength of the Lower Body in Supervised and in Combined Supervised and
Unsupervised Low-Load Resistance Training.
指導下あるいは指導・非指導を組み合わせた場合の低負荷レジスタンストレーニングにおける下半身の筋サイズと筋力
Journal of sports science and medicine 19(4):721-726, 2020.
Risa Nozaki, Yung-Li Hung, Kana Takagi, Daiki Nakano, Takako Fujii, Noriaki Kawanishi,
Takeshi Okamoto, Shuichi Machida.
Differential protective effects of Radix astragali, herbal medicine, on
immobilization-induced atrophy of slow-twitch and fast-twitch muscles.
不動による遅筋と速筋の萎縮に対するオウギ(生薬)の差次的な保護効果
Biomedical research (Tokyo, Japan) 41(3):139-148, 2020.
2019年
Hayao Ozaki, Takashi Nakagata, Toshinori Yoshihara, Tomoharu Kitada, Toshiharu Natsume,
Yoshihiko Ishihara, Pengyu Deng, Hiroyuki Kobayashi, Shuichi Machida, Hisashi Naito.
Effects of Progressive Walking and Stair-Climbing Training Program on Muscle Size and
Strength of the Lower Body in Untrained Older Adults.
プログレッシブウォーキングと階段昇降のトレーニングプログラムが非訓練高齢者の下半身の筋サイズと筋力に及ぼす影響について
Journal of sports science and medicine 18(4):722-728, 2019.
Toshinori Yoshihara,
Shuichi Machida, Takamasa Tsuzuki, Ryo Kakigi, Shuo-Wen Chang, Takao Sugiura, Hisashi
Naito.
Age-related changes in histone modification in rat gastrocnemius muscle.
ラット腓腹筋におけるヒストン修飾の加齢による変化
Experimental gerontology 125(1):110658, 2019.
Yusuke Yoshimura,
Muneaki Ishijima, Masayoshi Ishibashi, Liz Liu, Eri Arikawa-Hirasawa, Shuichi Machida,
Hisashi Naito, Chieko Hamada, Eiki Kominami.
A nationwide observational study of locomotive syndrome in Japan using the ResearchKit:
The Locomonitor study.
iPhoneアプリ「ロコモニター」「ResearchKit」を用いた日本におけるロコモティブシンドロームの全国的な観察研究
Journal of orthopaedic science 24(6):1094-1104, 2019.
Toshinori Yoshihara,
Shuo-Wen Chang, Takamasa Tsuzuki, Toshiharu Natsume, Ryo Kakigi, Takao Sugiura, Hisashi
Naito.
Sex-specific differences in rat soleus muscle signaling pathway responses to a bout of
horizontal and downhill running.
平地・下り坂ランニングに対するラットヒラメ筋シグナル伝達経路反応の性差
Journal of physiology and biochemistry 75(4):585-595, 2019.
Takisawa Shoko,
Funakoshi Tomoko, Yatsu Tomofumi, Nagata Kisaburo, Aigaki Toshiro, Machida Shuichi,
Ishigami Akihito.
Vitamin C deficiency causes muscle atrophy and a deterioration in physical
performance.
ビタミンC不足は、筋肉萎縮と身体能力の低下を引き起こす
Scientific reports 9(1):4702, 2019.
Yoshihara Toshinori,
Ozaki Hayao, Nakagata Takashi, Natsume Toshiharu, Kitada Tomoharu, Ishihara Yoshihiko,
Sawada Shuji, Ishibashi Masayoshi, Kobayashi Hiroyuki, Machida Shuichi, Naito Hisashi.
Association between locomotive syndrome and blood parameters in Japanese middle-aged and
elderly individuals: a cross-sectional study.
日本の中高年におけるロコモティブシンドロームと血液成分との関連性:横断的研究
BMC Musculoskeletal Disorders 20(1):104, 2019.
Toshinori Yoshihara,
Toshiharu Natsume, Takamasa Tsuzuki, Shuo-Wen Chang, Ryo Kakigi, Takao Sugiura, Hisashi
Naito.
Sex differences in forkhead box O3a signaling response to hindlimb unloading in rat
soleus muscle.
ラットヒラメ筋における後肢懸垂に対するフォークヘッドボックスO3aシグナル伝達反応の性差
The journal of physiological sciences 69(2):235-244, 2019.
2018年
Hayao Ozaki, Atsushi
Kubota, Toshiharu Natsume, Jeremy P. Loenneke, Takashi Abe, Shuichi Machida, Hisashi
Naito.
Effects of drop sets with resistance training on increases in muscle CSA, strength, and
endurance: a pilot study.
レジスタンストレーニングのドロップセットが筋CSA、筋力、持久力の向上に及ぼす影響:予備的研究
Journal of sports sciences 36(6):691-696, 2018.
Noriaki Kawanishi, Kana
Takagi, Hyeon-Cheol Lee, Daiki Nakano, Toshiaki Okuno, Takehiko Yokomizo, Shuichi
Machida.
Endurance exercise training and high-fat diet differentially affect composition of
diacylglycerol molecular species in rat skeletal muscle.
ラット骨格筋におけるジアシルグリセロールの分子種構成に及ぼす持久運動トレーニングと高脂肪食の影響
American journal of physiology. Regulatory, integrative and comparative physiology
314(6):R892-R901, 2018.
Yukino Hatazawa, Yusuke Ono,
Yuma Hirose, Sayaka Kanai, Nobuharu L Fujii, Shuichi Machida, Ichizo Nishino, Takahiko
Shimizu, Masaki Okano, Yasutomi Kamei, Yoshihiro Ogawa.
Reduced Dnmt3a increases Gdf5 expression with suppressed satellite cell differentiation
and impaired skeletal muscle regeneration.
Dnmt3aの減少による、衛星細胞の分化抑制および骨格筋の再生低下をともなうGdf5発現の増加
FASEB journal: official publication of the Federation of American societies for experimental
biology 32(3):1452-1467, 2018.
Tomoko Funakoshi,
Noriyuki Kanzaki, Yuta Otsuka, Takayuki Izumo, Hiroshi Shibata, Shuichi Machida.
Quercetin inhibits adipogenesis of muscle progenitor cells in vitro.
ケルセチンはin vitroでの筋肉前駆細胞の脂肪形成を阻害する
Biochemistry and biophysics reports 13:39-44, 2018.
Yuri Yamashita, Satoshi
Nakada, Toshinori Yoshihara, Takeshi Nara, Norihiko Furuya, Takashi Miida, Nobutaka
Hattori, Eri Arikawa-Hirasawa.
Perlecan, a heparan sulfate proteoglycan, regulates systemic metabolism with dynamic
changes in adipose tissue and skeletal muscle.
ヘパラン硫酸プロテオグリカンであるパールカンは、脂肪組織や骨格筋でダイナミックに変化しながら全身の代謝を調節する
Scientific reports 8(1):7766-7766, 2018.
Yuko Hashimoto, Ko
Matsudaira, Susumu S Sawada, Yuko Gando, Ryoko Kawakami, Robert A Sloan, Chihiro
Kinugawa, Takashi Okamoto, Koji Tsukamoto, Motohiko Miyachi, Hisashi Naito.
Association between objectively measured physical activity and body mass index with low
back pain: a large-scale cross-sectional study of Japanese men.
客観的に測定された身体活動量および肥満度と腰痛との関連性:日本人男性を対象とした大規模横断的研究
BMC public health. 18(1): 341, 2018.
Natsume Toshiteru,
Yoshihara Toshinoti, Naito Hisashi.
Electromyostimulation with blood flow restriction enhances activation of mTOR and MAPK
signaling pathways in rat gastrocnemius muscles.
血流制限を伴う電気筋刺激は、ラット腓腹筋のmTORおよびMAPKシグナル伝達経路の活性化を促進する
Applied physiology, nutrition, and metabolism 44(6):637-644, 2018.
Toshinori Yoshihara, Hayao
Ozaki, Takashi Nakagata, Toshiharu Natsume, Tomoharu Kitada, Yoshihiko Ishihara, Pengyu
Deng, Takuya Osawa, Masayoshi Ishibashi, Muneaki Ishijima, Hiroyuki Kobayashi, Shuichi
Machida, Hisashi Naito.
Effects of a progressive walking program on the risk of developing locomotive syndrome
in elderly Japanese people: a single-arm trial.
高齢日本人のロコモティブシンドローム発症リスクに対するプログレッシブウォーキングプログラムの効果:シングルアーム試験
Journal of physical therapy science 30(9):1180-1186, 2018.
2017年
Erika Koltai, Zoltan Bori, Clovis
Chabert, Herve Dubouchaud, Hisashi Naito, Shuichi Machida, Kelvin J. A. Davies, Zsolt
Murlasits, Andrew C. Fry, Istvan Boldogh, Zsolt Radak.
SIRT1 may play a crucial role in overload-induced hypertrophy of skeletal muscle.
SIRT1は、過負荷による骨格筋の肥大に重要な役割を果たしていると考えられる
Journal of physiology-London 595(11):3361-3376, 2017.
Akiko Amano, Yoshitaka
Kondo, Yoshihiro Noda, Mitsuhiro Ohta, Noriaki Kawanishi, Shuichi Machida, Kazuteru
Mitsuhashi, Takafumi Senmaru, Michiaki Fukui, Osamu Takaoka, Taisuke Mori, Jo Kitawaki,
Masafumi Ono, Toshiji Saibara, Hiroshi Obayashi, Akihito Ishigami.
Abnormal lipid/lipoprotein metabolism and high plasma testosterone levels in male but
not female aromatase-knockout mice.
アロマターゼノックアウトマウスでは、雌ではなく雄で脂質・リポ蛋白質代謝の異常と血漿テストステロン値が高くなる
Archives of biochemistry and biophysics 622:47-58, 2017.
Noriaki Kawanishi, Risa
Nozaki, Hisashi Naito, Shuichi Machida.
TLR4-defective (C3H/HeJ) mice are not protected from cast immobilization-induced muscle
atrophy.
TLR4欠損マウス(C3H/HeJ)はギブス固定による筋萎縮を回避できない
Physiological reports 5(8):e13255, 2017.
Shuo-wen Chang,
Toshinori Yoshihara, Shuichi Machida, Hisashi Naito.
Circadian rhythm of intracellular protein synthesis signaling in rat cardiac and
skeletal muscles.
ラット心筋および骨格筋における細胞内タンパク質合成シグナルの概日リズム
Biochemistry and Biophysics Reports 9:153-158, 2017.
Takamasa Tsuzuki,
Hiroyuki Kobayashi, Toshinori Yoshihara, Ryo Kakigi, Noriko Ichinoseki-Sekine, Hisashi
Naito.
Attenuation of exercise-induced heat shock protein 72 expression blunts improvements in
whole-body insulin resistance in rats with type 2 diabetes.
2型糖尿病ラットにおいて、運動による熱ショックタンパク質72の発現を抑制すると、全身のインスリン抵抗性の改善が鈍化する
Cell stress and chaperones 22(2):263-269, 2017.
Takeshi Okamoto, Shuichi
Machida.
Changes in FOXO and proinflammatory cytokines in the late stage of immobilized fast and
slow muscle atrophy.
不動性速筋・遅筋萎縮の後期におけるFOXOと炎症性サイトカインの変化
Biomedical research (Japan) 38(6):331-342, 2017.
2016年
Muneaki Ishijima, Haruka
Kaneko, Shinnosuke Hada, Mayuko Kinoshita, Ryo Sadatsuki, Lizu Liu, Yukio Shimura,
Hitoshi Arita, Jun Shiozawa, Anwarjan Yusup, Ippei Futami, Yuko Sakamoto, Masayoshi
Ishibashi, Syuichi Machida, Hisashi Naito, Eri Arikawa-Hirasawa, Chieko Hamada,
Yoshitomo Saita, Yuji Takazawa, Hiroshi Ikeda, Yasunori Okada & Kazuo Kaneko.
Osteoarthritis as a Cause of Locomotive Syndrome: Its Influence on Functional Mobility
and Activities of Daily Living.
ロコモティブシンドロームの原因としての変形性関節症:機能動作と日常生活への影響
Clinical reviews in bone and mineral metabolism 14(2):77-104, 2016.
Toshio Itaka,
Kenichiro Agemizu, Seiji Aruga, Shuichi Machida.
G allele of the IGF2 ApaI polymorphism is associated with judo status.
IGF2 ApaI多型のGアリルは、柔道家の競技レベルと関連している
Journal of strength and conditioning research 30(7):2043-2048, 2016.
Toshinori Yoshihara,
Shuichi Machida, Yuka Kurosaka, Ryo Kakigi, Takao Sugiura, Hisashi Naito.
Immobilization induces nuclear accumulation of HDAC4 in rat skeletal muscle.
不動はラット骨格筋におけるHDAC4の核内蓄積を誘導する
Journal of physiological sciences 66(4):337-343, 2016.
Tsubasa Shibaguchi,
Takao Sugiura, Takanori Fujitsu, Takumi Nomura, Toshinori Yoshihara, Hisashi Naito,
Toshitada Yoshioka, Akihiko Ogura, Yoshinobu Ohira.
Effects of icing or heat stress on the induction of fibrosis and/or regeneration of
injured rat soleus muscle.
負傷したラットヒラメ筋の線維化および再生に及ぼすアイシングおよび熱ストレスの影響
Journal of physiological sciences 66(4):345-357, 2016.
Naoki Kikuchi, Eri
Miyamoto-Mikami, Haruka Murakami, Tomohiro Nakamura, Seok-Ki Min, Masuhiko Mizuno,
Hisashi Naito, Motohiko Miyachi, Koichi Nakazato, Noriyuki Fuku.
ACTN3 R577X genotype and athletic performance in a large cohort of Japanese
athletes.
日本人スポーツ選手の大規模コホートにおけるACTN3 R577X遺伝子型と運動能力の関係
European journal of sport science 16(6):694-701, 2016.
Hayao Ozaki, Tomoharu Kitada,
Takashi Nakagata, Hisashi Naito.
A combination of body mass-based resistance training and high-intensity walking can
improve both muscle size and VO2peak in untrained older women.
体格に応じたレジスタンストレーニングと高強度のウォーキングを組み合わせることで、トレーニングをしていない高齢女性の筋サイズとVO2peakの両方を改善することができる
Geriatrics and gerontology international 17(5):779-784, 2016.
2015年
Toshinori
Yoshihara, Noriko Ichinoseki-Sekine, Ryo Kakigi, Takamasa Tsuzuki, Takao Sugiura, Scott
K. Powers, Hisashi Naito.
Repeated exposure to heat stress results in a diaphragm phenotype that resists
ventilator-induced diaphragm dysfunction.
熱ストレスに繰り返しさらされると、人工呼吸器による横隔膜機能障害に抗う表現型が生じる
Journal of applied physiology 119(9):1023-1031, 2015.
Toshinori Yoshihara, Takao
Sugiura, Yuki Yamamoto, Tsubasa Shibaguchi, Ryo Kakigi, Hisashi Naito.
The response of apoptotic and proteolytic systems to repeated heat stress in atrophied
rat skeletal muscle.
繰り返しの熱ストレスにさらしたラット萎縮骨格筋におけるアポトーシスおよびタンパク質分解系の反応
Physiological reports 3(10):e12597, 2015.
Toshiharu Natsume,
Hayao Ozaki, Anneyuko I Saito, Takashi Abe, Hisashi Naito.
Effects of electrostimulation with blood flow restriction on muscle size and
strength.
血流制限を伴う電気刺激が筋サイズと筋力に及ぼす影響
Medicine and Science in sports and exercise 47(12):2621-2627, 2015.
Tomoharu Kitada,
Shuichi Machida, Hisashi Naito.
Influence of muscle fibre composition on muscle oxygenation during maximal running.
筋繊維組成が最大負荷走時の筋酸素濃度に及ぼす影響
BMJ open sport and exercise medicine 1(1):e000062, 2015.