2024年

Ide T, Izawa K, Diono W, Kamei A, Ando T, Kaitani A, Maehara A, Yoshikawa A, Yamamoto R, Uchida S, Wang H, Kojima M, Maeda K, Nakano N, Nakamura M, Shimizu T, Ogawa H, Okumura K, Matsumoto F, Ikeda K, Goto M, Kitaura J: Intranasal administration of ceramide liposomes suppresses allergic rhinitis by targeting CD300f in murine models. Sci Rep. 14: 8398, 2024. プレスリリース

Hirano T, Koyanagi A, Ago H, Yamamoto M, Kitaura J, Kasai M, Okumura K: Allosteric inhibition of IgE-FcεRI interactions by simultaneous targeting of IgE F(ab’)2 epitopes. Commun Biol. 7: 1042, 2024. プレスリリース

Nagamine M, Kaitani A, Izawa K, Ando T, Yoshikawa A, Nakamura M, Maehara A, Yamamoto R, Okamoto Y, Wang H, Yamada H, Maeda K, Nakano N, Shimizu T, Ogawa H, Okumura K, Kitaura J: Neuronal substance P-driven MRGPRX2-dependent mast cell degranulation products differentially promote vascular permeability. Front Immunol. in press.

Ando T, Takazawa I, Spencer ZT, Ito R, Tomimori Y, Mikulski Z, Matsumoto K, Ishitani T, Denson LA, Kawakami Y, Kawakami Y, Kitaura J, Ahmed Y, Kawakami T: Ileal Crohn’s Disease Exhibits Reduced Activity of Phospholipase C-β3-Dependent Wnt/β-Catenin Signaling Pathway. Cells. 13: 986, 2024.

Yamamoto R, Ando T, Kitaura J, Narita M, Miura K, Takasato Y, Nagao M, Okumura K, Ogawa H, Ohnishi H, Watanabe T, Ito K, Fujisawa T, Ebisawa M, Ohya Y, Kabasser S, Bublin M, Yasudo H: The utility of macadamia nut legumin Mac i 2 and its conformational epitopes in the diagnosis of macadamia nut allergy. J Allergy Clin Immunol Pract. 12: 786-788, 2024.

Nagasaka Y, Nakamura Y, Tran NQV, Kobayashi Y, Nakano N, Nakao A: Deficiency of BMAL1 promotes ROS generation and enhances IgE-dependent degranulation in mast cells. Biochem Biophys Res Commun. 690: 149295, 2024.

Muela-Zarzuela I, Suarez-Rivero JM, Gallardo-Orihuela A, Wang C, Izawa K, de Gregorio-Procopio M, Couillin I, Ryffel B, Kitaura J, Sanz A, von Zglinicki T, Mbalaviele G, Cordero MD. NLRP1 inflammasome promotes senescence and senescence-associated secretory phenotype. Inflamm Res. 73: 1253-1266, 2024.

2023年

Matsuzawa M, Ando T, Fukase S, Kimura M, Kume Y, Ide T, Izawa K, Kaitani A, Hara M, Nakamura E, Kamei A, Matsuda A, Nakano N, Maeda K, Tada N, Ogawa H, Okumura K, Murakami A, Ebihara N, Kitaura J: The protective role of conjunctival goblet cell mucin sialylation. Nat Commun. 14: 1417, 2023.［プレスリリース］

Kimura M, Ando T, Kume Y, Fukase S, Matsuzawa M, Kashiwagi K, Izawa K, Kaitani A, Nakano N, Maeda K, Ogawa H, Okumura K, Nakao S, Murakami A, Ebihara N, Kitaura J: A nerve-goblet cell association promotes allergic conjunctivitis through the rapid antigen passage. JCI Insight. 8: e168596, 2023. ［プレスリリース］

Zhang Z, Shibata T, Fujimura A, Kitaura J, Miyake K, Ohto U, Shimizu T: Structural basis for thioredoxin mediated suppression of NLRP1 inflammasome. Nature. 622: 188-194, 2023.［プレスリリース］

Yamamoto R, Ando T, Kitaura J, Narita M, Miura K, Takasato Y, Nagao M, Okumura K, Ogawa H, Ohnishi H, Watanabe T, Ito K, Fujisawa T, Ebisawa M, Ohya Y, Kabasser S, Bublin M, Yasudo H: The utility of macadamia nut legumin Mac i 2 and its conformational epitopes in the diagnosis of macadamia nut allergy. J Allergy Clin Immunol Pract. (in press) 2023.

Yamada H, Kaitani A, Izawa K, Ando T, Kamei A, Uchida S, Maehara A, Kojima M, Yamamoto R, Wang H, Nagamine M, Maeda K, Uchida K, Nakano N, Ohtsuka Y, Ogawa H, Okumura K, Shimizu T, Kitaura J: Staphylococcus aureus δ-toxin present on skin promotes the development of food allergy in a murine model. Front Immunol. 14: 1173069, 2023.

Yamamoto R, Izawa K, Ando T, Kaitani A, Tanabe A, Yamada H, Uchida S, Yoshikawa A, Kume Y, Toriumi S, Maehara A, Wang H, Nagamine M, Negishi N, Nakano N, Ebihara N, Shimizu T, Ogawa H, Okumura K, Kitaura J: Murine model identifies tropomyosin as IgE cross-reactive protein between house dust mite and coho salmon that possibly contributes to the development of salmon allergy. Front Immunol. 14: 1238297, 2023.

Ando T, Kitaura J, Maruyama N, Narita M, Miura K, Takasato Y, Nogami K, Nagao M, Okumura K, Ogawa H, Onishi H, Watanabe T, Ito K, Fujisawa T, Ebisawa M, Kawakami T, Matsumoto K, Hasegawa S, Ohya Y, Yasudo H: Sensitization to macadamia 7S globulin amino-terminus with clinical relevance in Japanese children with macadamia nut allergy. Allergol Int. 72: 351-353, 2023.

Shibata T, Sato R, Taoka M, Saitoh SI, Komine M, Yamaguchi K, Goyama S, Motoi Y, Kitaura J, Izawa K, Yamauchi Y, Tsukamoto Y, Ichinohe T, Fujita E, Hiranuma R, Fukui R, Furukawa Y, Kitamura T, Takai T, Tojo A, Ohtsuki M, Ohto U, Shimizu T, Ozawa M, Yoshida N, Isobe T, Latz E, Mukai K, Taguchi T, Hemmi H, Akira S, Miyake K: TLR7/8 stress response drives histiocytosis in SLC29A3 disorders. J Exp Med. 220: e20230054, 2023.

Nagata K, Araumi S, Ando D, Ito N, Ando M, Ikeda Y, Takahashi M, Noguchi S, Yasuda Y, Nakano N, Ando T, Hara M, Yashiro T, Hachisu M, Nishiyama C: Kaempferol Suppresses the Activation of Mast Cells by Modulating the Expression of FcεRI and SHIP1. Int J Mol Sci. 24: 5997, 2023.

Kawakami Y, Kimura M, Widjaja C, Kasakura K, Ando T, Kawakami Y, Obar JJ, Kawakami T: Regulation of Syk activity by antiviral adaptor MAVS in FcεRI signaling pathway. Front Allergy. 4: 1098474, 2023.

Nguyen PT, Nakamura Y, Tran NQV, Ishimaru K, Nguyen TA, Kobayashi Y, Watanabe-Saito F, Okuda T, Nakano N, Nakao A: Ethyl Caffeate Can Inhibit Aryl Hydrocarbon Receptor (AhR) Signaling and AhR-Mediated Potentiation of Mast Cell Activation. Int J Mol Sci. 24: 9997, 2023.

2022年

Kamei A, Izawa K, Ando T, Kaitani A, Yamamoto R, Maehara A, Ide T, Yamada H, Kojima M, Wang H, Tokushige K, Nakano N, Shimizu T, Ogawa H, Okumura K, Kitaura J: Development of mouse model for oral allergy syndrome to identify IgE cross-reactive pollen and food allergens: ragweed pollen cross-reacts with fennel and black pepper. Front Immunol. 13: 945222, 2022.

Yasudo H, Ando T, Kitaura J, Maruyama N, Narita M, Natsume O, Uneoka K, Miura K, Morita Y, Kamei A, Okamoto Y, Shirakawa S, Kitabayashi T, Kurihara K, Nogami K, Takasato Y, Nagao M, Ito K, Fujisawa T, Ebisawa M, Kawakami T, Matsumoto K, Saito H, Hasegawa S, Ohya Y: Predictive value of 7S globulin-specific IgE in Japanese macadamia nut allergy patients. J Allergy Clin Immunol Pract. 10: 1389-1391, 2022.

Nakano N, Kitaura J: Mucosal mast cells as key effector cells in food allergies. Cells. 11: 329, 2022. [review]

Kawakami T, Kasakura K, Kawakami Y, Ando T. Front Allergy. 3: 835748, 2022. [review]

Peng G, Tsukamoto S, Ikutama R, Le Thanh Nguyen H, Umehara Y, Trujillo-Paez JV, Yue H, Takahashi M, Ogawa T, Kishi R, Tominaga M, Takamori K, Kitaura J, Kageyama S, Komatsu M, Okumura K, Ogawa H, Ikeda S, Niyonsaba F: Human-β-defensin-3 attenuates atopic dermatitis-like inflammation through autophagy activation and the aryl hydrocarbon receptor signaling pathway. J Clin Invest. 132: e156501, 2022.

Ito N, Sakata F, Hachisu M, Nagata K, Ito T, Nomura K, Nagaoka M, Inaba K, Hara M, Nakano N, Nakajima T, Yashiro T, Nishiyama C: The Ccl17 gene encoding TARC is synergistically transactivated by PU.1 and IRF4 driven by the mammalian common promoter in dendritic cells. Allergy. 77:1054-1059, 2022.

2021年

Yasudo H, Ando T, Maehara A, Ando T, Izawa K, Tanabe A, Kaitani A, Nomura S, Seki M, Yoshida K, Oda H, Okamoto Y, Wang H, Kamei A, Kojima M, Kimura M, Uchida K, Nakano N, Kaneko J, Ebihara N, Hasegawa K, Shimizu T, Takita J, Ogawa H, Okumura K, Ogawa S, Tamura N, Kitaura J: A Possible Association Between a Nucleotide-Binding Domain LRR-Containing Protein Family PYD-Containing Protein 1 Mutation and an Autoinflammatory Disease Involving Liver Cirrhosis. Hepatology. 74: 2296-2299, 2021.［プレスリリース］

Yoneyama T, Nakano N, Hara M, Yamada H, Izawa K, Uchida K, Kaitani A, Ando T, Kitaura J, Ohtsuka Y, Ogawa H, Okumura K, Shimizu T：Notch signaling contributes to the establishment of sustained unresponsiveness to food allergens by oral immunotherapy. J Allergy Clin Immunol. 147: 1063-1076, 2021.［プレスリリース］

Nakano N, Saida K, Hara M, Izawa K, Ando T, Kaitani A, Kasakura K, Yashiro T, Nishiyama C, Ogawa H, Kitaura J, Okumura K: Mucosal Mast Cell-Specific Gene Expression Is Promoted by Interdependent Action of Notch and TGF-β Signaling. J Immunol. 207: 3098-3106, 2021.

Fukase S, Ando T, Matsuzawa M, Kimura M, Sone Y, Izawa K, Kaitani A, Kamei A, Kojima M, Nakano N, Maeda K, Shimizu T, Ogawa H, Okumura K, Nishiyama N, Murakami A, Ebihara N, Kitaura J: Pollen shells and soluble factors play non-redundant roles in the development of allergic conjunctivitis in mice. Ocul Surf. 22: 152-162, 2021.

Kitaura J, Murakami M: Positive and negative roles of lipids in mast cells and allergic responses. Curr Opin Immunol. 72: 186-195, 2021. [review]

Ando T, Kitaura J: Tuning IgE: IgE-Associating Molecules and Their Effects on IgE-Dependent Mast Cell Reactions. Cells. 10: 1697, 2021. [review]

Nakahashi-Oda C, Fujiyama S, Nakazawa Y, Kanemaru K, Wang Y, Lyu W, Shichita T, Kitaura J, Abe F, Shibuya A: CD300a blockade enhances efferocytosis by infiltrating myeloid cells and ameliorates neuronal deficit after ischemic stroke. Sci Immunol. 6: eabe7915, 2021.

Takasato Y, Kurashima Y, Kiuchi M, Hirahara K, Murasaki S, Arai F, Izawa K, Kaitani A, Shimada k, Saito Y, Toyoshima S, Nakamura M, Fujisawa K, Okayama Y, Kunisawa J, Kubo M, Takemura N, Uematsu S, Akira S, Kitaura J, Takahashi T, Nakayama T, Kiyono H: Orally desensitized mast cells form a regulatory network with Treg cells for the control of food allergy. Mucosal Immunol. 14: 640-651, 2021.

Fujimoto K, Uchida K, Yin E, Zhu J, Kojima Y, Uchiyama M, Yamamoto Y, Bashuda H, Matsumoto R, Tokushige K, Harada M, Inomata T, Kitaura J, Murakami A, Okumura K, Takeda K: Analysis of therapeutic potential of monocytic myeloid-derived suppressor cells in cardiac allotransplantation. Transpl Immunol. 67: 101405, 2021.

Sutthammikorn N, Supajatura V, Yue H, Takahashi M, Chansakaow S, Nakano N, Song P, Ogawa T, Ikeda S, Okumura K, Ogawa H, Niyonsaba F. Plants (Basel). 10: 1122, 2021.

Yin E (PD), Fukuhara T, Takeda K, Kojima Y, Fukuhara K, Ikejima K, Bashuda H, Kitaura J, Yagita H, Okumura K, Uchida K: Anti-CD321 antibody immunotherapy protects liver against ischemia and reperfusion-induced injury. Sci Rep. 11: 6312, 2021.

2020年

Uchida S, Izawa K, Ando T, Yamada H, Uchida K, Negishi N, Kaitani A, Maehara A, Nagamine M, Kamei A, Takamori A, Maeda K, Nakano N, Shimizu T, Ogawa H, Okumura K, Nagahara A, Watanabe S, Kitaura J：CD300f is a potential therapeutic target for the treatment of food allergy. Allergy. 75: 471-474, 2020.

*Izawa K, *Kaitani A (PD), Ando T, Maehara A, Nagamine M, Yamada H, Ando T, Ide T, Matsuzawa M, Okamoto Y, Yin E, Fukase S, Wang H, Kamei A, Uchida S, Maeda K, Nakano N, Uchida K, Tamura N, Ikeda K, Ebihara N, Shimizu T, Voehringer D, Roers A, Ogawa H, Okumura K, Kitaura J：Differential lipid recognition by mouse versus human CD300f, inhibiting passive cutaneous anaphylaxis, depends on a single amino acid substitution in its immunoglobulin-like domain. J Invest Dermatol. 140: 710-713, 2020.

2019年

Takahashi M, Izawa K, Urai M, Yamanishi Y, Maehara A, Isobe M, Matsukawa T, Kaitani A, Takamori A, Uchida S, Yamada H, Nagamine M, Ando T, Shimizu T, Ogawa H, Okumura K, Kinjo Y, Kitamura T, Kitaura J：The phytosphingosine-CD300b interaction promotes zymosan-induced, nitric oxide-dependent neutrophil recruitment. Sci Signal. 12: 564, 2019.［プレスリリース］

Takamori A (PD), Izawa K, Kaitani A, Ando T, Okamoto Y, Maehara A, Tanabe A, Nagamine M, Yamada H, Uchida S, Uchida K, Isobe M, Hatayama T, Watanabe D, Ando T, Ide T, Matsuzawa M, Maeda K, Nakano N, Tamura N, Ikeda K, Ebihara N, Shimizu T, Ogawa H, Okumura K, Kitaura J：Identification of inhibitory mechanisms in pseudo-allergy involving Mrgprb2/MRGPRX2-mediated mast cell activation. J Allergy Clin Immunol. 143: 1231-1235, 2019.［プレスリリース］

Hayashi Y, Harada Y, Kagiyama Y, Nishikawa S, Ding Y, Imagawa J, Shingai N, Kato N, Kitaura J, Hokaiwado S, Maemoto Y, Ito A, Matsui H, Kitabayashi I, Iwama A, Komatsu N, Kitamura T, Harada H： NUP98-HBO1-fusion generates phenotypically and genetically relevant chronic myelomonocytic leukemia pathogenesis. Blood Adv. 3: 1047-1060, 2019.

Yamazaki T, Inui M, Hiemori K, Tomono S, Itoh M, Ichimonji I, Nakashima A, Takagi H, Biswas M, Izawa K, Kitaura J, Imai T, Sugiura N, Tateno H, Akashi-Takamura S: Receptor destroying enzyme (RDE) from Vibrio cholerae modulates IgE activity and reduces the initiation of anaphylaxis. J Biol Chem. 294: 6659-6669, 2019.

Ito T, Egusa C, Maeda T, Numata T, Nakano N, Nishiyama C, Tsuboi R: Stem cell factor suppressed IL-33-induced MHC class II expression in murine bone marrow-derived mast cells. Allergol Int. 68: 264-267, 2019.

Kashiwakura JI, Ando T, Karasuyama H, Kubo M, Matsumoto K, Matsuda T, Kawakami T: The basophil-IL-4-mast cell axis is required for food allergy. Allergy. 74: 1992-1996, 2019.

Ando T, Kawakami T: Awaiting allograft antigen: For rejection or tolerance? J Allergy Clin Immunol. 143: 560-562, 2019.

2018年

Negishi N, Sato T, Yamashita-Kanemaru Y, Shibuya K, Uchida K, Kametani Y, Yagita H, Kitaura J, Okumura K, Habu S: CD155-Transducing Signaling through TIGIT Plays an Important Role in Transmission of Tolerant State and Suppression Capacity. ImmunoHorizons. 2:338-348, 2018.

Ueno K, Urai M, Izawa K, Otani Y, Yanagihara N, Kataoka M, Takatsuka S, Abe M, Hasegawa H, Shimizu K, Kitamura T, Kitaura J, Miyazaki Y, Kinjo Y: Mouse LMIR3/CD300f is a negative regulator of the antimicrobial activity of neutrophils. Sci Rep. 8: 17406, 2018.

Hirano T, Koyanagi A, Kotoshiba K, Shinkai Y, Kasai M, Ando T, Kaitani A, Okumura K, Kitaura J: The Fab fragment of anti-IgE Cε2 domain prevents allergic reactions through interacting with IgE-FcεRIα complex on rat mast cells. Sci Rep. 8:14237, 2018.［プレスリリース］

Kaitani A (PD), Izawa K, Maehara A, Isobe M, Takamori A, Matsukawa T, Takahashi M, Yamanishi Y, Oki T, Yamada H, Nagamine M, Uchida S, Uchida K, Ando T, Maeda K, Nakano N, Shimizu T, Takai T, Ogawa H, Okumura K, Kitamura T, Kitaura J:　Leukocyte mono-immunoglobulin-like receptor 8 (LMIR8)/CLM-6 is an FcRγ-coupled receptor selectively expressed in mouse tissue plasmacytoid dendritic cells. Sci Rep. 8:8259, 2018.

Takamori A (PD), Nambu A, Sato K, Yamaguchi S, Matsuda K, Numata T, Sugawara T, Yoshizaki T, Arae K, Morita H, Matsumoto K, Sudo K, Okumura K, Kitaura J, Matsuda H, Nakae S: IL-31 is crucial for induction of pruritus, but not inflammation, in contact hypersensitivity. Sci Rep. 8:6639, 2018.

Isobe M (PD), Izawa K, Sugiuchi M, Sakanishi T, Kaitani A, Takamori A, Maehara A, Matsukawa T, Takahashi M, Yamanishi Y, Oki T, Uchida S, Uchida K, Ando T, Maeda K, Nakano N, Yagita H, Takai T, Ogawa H, Okumura K, Kitamura T, Kitaura J: The CD300e molecule in mice is an immune-activating receptor. J Biol Chem. 293:3793-3805, 2018.

*Maehara A (PD), *Kaitani A (PD), Izawa K, Shiba E, Nagamine M, Takamori A, Isobe M, Uchida S, Uchida K, Ando T, Keiko M, Nakano N, Voehringer D, Roers A, Shimizu T, Ogawa H, Okumura K, Kitamura T, Kitaura J: Role of the ceramide-CD300f interaction in gram-negative bacterial skin infections. J Invest Dermatol. 138:1221-1224, 2018.

Kawabata KC, Hayashi Y, Inoue D, Meguro H, Sakurai H, Fukuyama T, Tanaka Y, Asada S, Fukushima T, Nagase R, Takeda R, Harada Y, Kitaura J, Goyama S, Harada H, Aburatani H, Kitamura T: High expression of ABCG2 induced by EZH2 disruption plays pivotal roles in MDS pathogenesis. Leukemia. 32:419-428, 2018.

2017年

Izawa K, Maehara A, Isobe M, Yasuda Y, Urai M, Hoshino Y, Ueno K, Matsukawa T, Takahashi M, Kaitani A, Shiba E, Takamori A, Uchida S, Uchida K, Maeda K, Nakano N, Yamanishi Y, Oki T, Voehringer D, Roers A, Nakae S, Ishikawa J, Kinjo Y, Shimizu T, Ogawa H, Okumura K, Kitamura T, Kitaura J: Disrupting ceramide-CD300f interaction prevents septic peritonitis by stimulating neutrophil recruitment. Sci Rep. 7:4298, 2017.［プレスリリース］

Honjo A, Nakano N, Yamazaki S, Hara M, Uchida K, Kitaura J, Nishiyama C, Yagita H, Ohtsuka Y, Ogawa H, Okumura K, Shimizu T: Pharmacological inhibition of Notch signaling suppresses food antigen-induced mucosal mast cell hyperplasia. J Allergy Clin Immunol. 139:987-996, 2017.

Shiba E, Izawa K, Kaitani A, Isobe M, Maehara A, Uchida K, Maeda K, Nakano N, Ogawa H, Okumura K, Kitamura T, Shimizu T, Kitaura J: Ceramide-CD300f Binding Inhibits Lipopolysaccharide-induced Skin Inflammation. J Biol Chem. 292: 2924-2932, 2017.

Kawauchi T, Ishimaru K, Nakamura Y, Nakano N, Hara M, Ogawa H, Okumura K, Shibata S, Nakao A: Clock-dependent temporal regulation of IL-33/ST2-mediated mast cell response. Allergol Int. 66: 472-478, 2017.

Nagaoka M, Yashiro T, Uchida Y, Ando T, Hara M, Arai H, Ogawa H, Okumura K, Kasakura K, Nishiyama C: The Orphan Nuclear Receptor NR4A3 Is Involved in the Function of Dendritic Cells. J Immunol. 199: 2958-2967, 2017.

Ando T, Kashiwakura JI, Itoh-Nagato N, Yamashita H, Baba M, Kawakami Y, Tsai SH, Inagaki N, Takeda K, Iwata T, Shimojo N, Fujisawa T, Nagao M, Matsumoto K, Kawakami Y, Kawakami T: Histamine-releasing factor enhances food allergy. J Clin Invest. 127: 4541-4553, 2017.

Kawakami Y, Ando T, Lee JR, Kim G, Kawakami Y, Nakasaki T, Nakasaki M, Matsumoto K, Choi YS, Kawakami T: Defective natural killer cell activity in a mouse model of eczema herpeticum. J Allergy Clin Immunol. 139: 997-1006, 2017.

2016年

Matsukawa T, Izawa K, Isobe M, Takahashi M, Maehara A, Yamanishi Y, Kaitani A, Okumura K, Teshima T, Kitamura T, Kitaura J: Ceramide-CD300f binding suppresses experimental colitis by inhibiting ATP-mediated mast cell activation. Gut. 65: 777-87, 2016.［プレスリリース］

Kitamura T, Watanabe-Okochi N, Enomoto Y, Nakahara F, Oki T, Komeno Y, Kato N, Doki N, Uchida T, Kagiyama Y, Togami K, Kawabata KC, Nishimura K, Hayashi Y, Nagase R, Saika M, Fukushima T, Asada S, Fujino T, Izawa Y, Horikawa S, Fukuyama T, Tanaka Y, Ono R, Goyama S, Nosaka T, Kitaura J, Inoue D: Novel working hypothesis for pathogenesis of hematological malignancies: Combination of mutations-induced cellular phenotypes determines the disease (cMIP-DD). J Biochem. 159: 17-25, 2016.

Nakamura Y, Nakano N, Ishimaru K, Ando N, Katoh R, Suzuki-Inoue K, Koyanagki S, Ogawa H, Okumura K, Shibata S, Nakao A: Inhibition of IgE-mediated allergic reactions by pharmacologically targeting the circadian clock. J Allergy Clin Immunol. 137: 1226-1235, 2016.

Miura R, Kasakura K, Nakano N, Hara M, Maeda K, Okumura K, Ogawa H, Yashiro T, Nishiyama C: Role of PU.1 in MHC Class II Expression via CIITA Transcription in Plasmacytoid Dendritic Cells. PLoS One. 11: e0154094, 2016.

2015年

Carnec X, Meertens L, Dejarnac O, Perera-Lecoin M, Lamine Hafirassou M, Kitaura J, Ramdasi R, Schwartz O, Amara A: The phosphatidylserine and phosphatidylethanolamine receptor CD300a binds dengue virus and enhances infection. J Virol. 90: 92-102, 2015.

Yamazaki S, Nakano N, Honjo A, Hara M, Maeda K, Nishiyama C, Kitaura J, Ohtsuka Y, Okumura K, Ogawa H, Shimizu T: The Transcription Factor Ehf Is Involved in TGF-β-Induced Suppression of FcεRI and c-Kit Expression and FcεRI-Mediated Activation in Mast Cells. J Immunol. 195: 3427-3435, 2015.

Togami K, Kitaura J, Uchida T, Inoue D, Nishimura K, Kawabata KC, Nagase R, Horikawa S, Izawa K, Fukuyama T, Nakahara F, Oki T, Harada Y, Harada H, Aburatani H, Kitamura T: A C-terminal mutant of C/EBPα (C/EBPα-C^m) down-regulates the Csf1r, a potent accelerator in the progression of AML with C/EBPα-C^m. Exp Hematol. 43: 300-308, 2015.

Inoue D, Kitaura J, Matsui H, Hou HA, Chou WC, Nagamachi A, Kawabata KC, Togami K, Nagase R, Horikawa S, Saika M, Micol JB, Hayashi Y, Harada Y, Harada H, Inaba T, Tien HF, Abdel-Wahab O, Kitamura T: SETBP1 mutations drive leukemic transformation in ASXL1-mutated MDS. Leukemia. 29: 847-857, 2015.

Nakano N, Nishiyama C, Yagita H, Hara M, Motomura Y, Kubo M, Okumura K, Ogawa H: Notch signaling enhances FcεRI-mediated cytokine production by mast cells through direct and indirect mechanisms. J Immunol. 194: 4535-4344, 2015.

Ishiyama K, Yashiro T, Nakano N, Kasakura K, Miura R, Hara M, Kawai F, Maeda K, Tamura N, Okumura K, Ogawa H, Takasaki Y, Nishiyama C: Involvement of PU.1 in NFATc1 promoter function in osteoclast development. Allergol Int. 64: 241-247, 2015.

Ito T, Egusa C, Maeda T, Numata T, Nakano N, Nishiyama C, Tsuboi R: IL-33 promotes MHC class II expression in murine mast cells. Immun Inflamm Dis. 3: 196-208, 2015.

Yasudo H, Ando T, Hiwatari M, Oka A: Suplatast tosilate for treating cutaneous mastocytosis. Pediatr Dermatol. 32: e118-119, 2015.

Kawakami T, Ando T, Kawakami Y: Hypothetical Atopic Dermatitis-Myeloproliferative Neoplasm Syndrome. Front Immunol. 24: 434, 2015.

2014年

Izawa K, Isobe M, Matsukawa T, Ito S, Maehara A, Takahashi M, Yamanishi Y, Kaitani A, Oki T, Okumura K, Kitamura T, Kitaura J: Sphingomyelin and ceramide are physiological ligands for human LMIR3/CD300f, inhibiting FcεRI-mediated mast cell activation. J Allergy Clin Immunol. 133: 270-273, 2014.

Oki T, Nishimura K, Kitaura J, Togami K, Maehara A, Izawa K, Sakaue-Sawano A, Niida A, Miyano S, Aburatani H, Kiyonari H, Miyawaki A, Kitamura T: A novel cell-cycle-indicator, mVenus-p27K-, identifies quiescent cells and visualizes G0-G1 transition. Sci Rep. 4: 4012, 2014.

Uchida T, Kitaura J, Nakahara F, Togami K, Inoue D, Maehara A, Nishimura K, Kawabata KC, Doki N, Kakihana K, Yoshioka K, Izawa K, Oki T, Sada A, Harada Y, Ohashi K, Katayama Y, Matsui T, Harada H, Kitamura T: Hes1 up-regulation contributes to the development of FIP1L1-PDGFRA-positive leukemia in blast crisis. Exp Hematol. 42: 369-379, 2014.

Nakahara F, Kitaura J, Uchida T, Nishida C, Togami K, Inoue D, Matsukawa T, Kagiyama Y, Enomoto Y, Kawabata KC, Chen-Yi L, Komeno Y, Izawa K, Oki T, Nagae G, Harada Y, Harada H, Otsu M, Aburatani H, Heissig B, Hattori K, Kitamura T: Hes1 promotes blast crisis in chronic myelogenous leukemia through MMP-9 upregulation in leukemic cells. Blood. 123: 3932-3942, 2014.

Kitamura T, Inoue D, Okochi-Watanabe N, Kato N, Komeno Y, Lu Y, Enomoto Y, Doki N, Uchida T, Kagiyama Y, Togami K, Kawabata KC, Nagase R, Horikawa S, Hayashi Y, Saika M, Fukuyama T, Izawa K, Oki T, Nakahara F, Kitaura J: The molecular basis of myeloid malignancies. Proc Jpn Acad Ser B Phys Biol Sci. 90: 389-404, 2014.

Inage E, Kasakura K, Yashiro T, Suzuki R, Baba Y, Nakano N, Hara M, Tanabe A, Oboki K, Matsumoto K, Saito H, Niyonsaba F, Ohtsuka Y, Ogawa H, Okumura K, Shimizu T, Nishiyama C: Critical Roles for PU.1, GATA1, and GATA2 in the expression of human FcεRI on mast cells: PU.1 and GATA1 transactivate FCER1A, and GATA2 transactivates FCER1A and MS4A2. J Immunol. 192: 3936-3946, 2014.

Nakamura Y, Nakano N, Ishimaru K, Hara M, Ikegami T, Tahara Y, Katoh R, Ogawa H, Okumura K, Shibata S, Nishiyama C, Nakao A: Circadian regulation of allergic reactions by the mast cell clock in mice. J Allergy Clin Immunol. 133: 568-575, 2014.

Ando T, Xiao W, Gao P, Namiranian S, Matsumoto K, Tomimori Y, Hong H, Yamashita H, Kimura M, Kashiwakura JI, Hata TR, Izuhara K, Gurish MF, Roers A, Rafaels NM, Barnes KC, Jamora C, Kawakami Y, Kawakami T: Critical Role for Mast Cell Stat5 Activity in Skin Inflammation. Cell Rep. 30: 366-376, 2014.

Yasudo H, Ando T, Takeuchi M, Nakano H, Itonaga T, Takehara H, Isojima T, Miura K, Harita Y, Takita J, Oka A: Systemic lupus erythematosus complicated with liver cirrhosis in a patient with Papillon-Lefevre syndrome, Lupus. 23: 1523-1527, 2014.

～2013年

Takahashi M, Izawa K, Kashiwakura J, Yamanishi Y, Enomoto Y, Kaitani A, Maehara A, Isobe M, Ito S, Matsukawa T, Nakahara F, Oki T, Kajikawa M, Ra C, Okayama Y, Kitamura T, Kitaura J: Human CD300C Delivers an Fc Receptor-γ-dependent Activating Signal in Mast Cells and Monocytes and Differs from CD300A in Ligand Recognition. J Biol Chem. 288: 7662-7675, 2013.

Watanabe-Okochi N, Yoshimi A, Sato T, Ikeda T, Kumano K, Taoka K, Satoh Y, Shinohara A, Tsuruta T, Masuda A, Yokota H, Yatomi Y, Takahashi K, Kitaura J, Kitamura T, Kurokawa M: The shortest isoform of C/EBPβ, Liver inhibitory protein (LIP), collaborates with Evi1 to induce AML in a mouse BMT model. Blood. 121: 4142-4155, 2013.

Nishimura K, Oki T, Kitaura J, Kuninaka S, Saya H, Sakaue-Sawano A, Miyawaki A, Kitamura T: APCCDH1 targets MgcRacGAP for destruction in the late M phase. PLOS One. 8, e63001, 2013.

Inoue D, Kitaura J, Togami K, Nishimura K, Enomoto Y, Uchida T, Kagiyama Y, Kawabata KC, Nakahara F, Izawa K, Oki T, Maehara A, Isobe M, Tsuchiya A, Harada Y, Harada H, Ochiya T, Aburatani H, Kimura H, Thol F, Heuser M, Levine RL, Abdel-Wahab O, Kitamura T: Myelodysplastic syndromes are induced by histone methylation-altering ASXL1 mutations. J Clin Invest. 123: 4627-4640, 2013.

Ando T, Matsumoto K, Namiranian S, Yamashita H, Glatthorn H, Kimura M, Dolan BR, Lee JJ, Galli SJ, Kawakami Y, Jamora C, Kawakami T: Mast cells are required for full expression of allergen/SEB-induced skin inflammation. J Invest Dermatol. 133: 2695-2705, 2013.

Kawakami T, Ando T: Salmonella’s Masterful Skill in Mast Cell Suppression. Immunity. 39: 996-998, 2013

Izawa K, Yamanishi Y, Maehara A, Takahashi M, Isobe M, Ito S, Kaitani A, Matsukawa T, Matsuoka T, Nakahara F, Oki T, Kiyonari H, Abe T, Okumura K, Kitamura T, Kitaura J: The receptor LMIR3 negatively regulates mast cell activation and allergic responses by binding to extracellular ceramide. Immunity. 37: 827-839, 2012.［プレスリリース］

Yamanishi Y, Takahashi M, Izawa K, Isobe M, Ito S, Tsuchiya A, Maehara A, Kaitani A, Uchida T, Togami K, Enomoto Y, Nakahara F, Oki T, Kajikawa M, Kurihara H, Kitamura T, Kitaura J: A Soluble Form of LMIR5/CD300b Amplifies Lipopolysaccharide-Induced Lethal Inflammation in Sepsis. J Immunol. 189, 1773-1779, 2012.

Shibata T, Takemura N, Motoi Y, Goto Y, Karuppuchamy T, Izawa K, Li X, Akashi-Takamura S, Tanimura N, Kunisawa J, Kiyono H, Akira S, Kitamura T, Kitaura J, Uematsu S, Miyake K: PRAT4A-dependent expression of cell surface TLR5 on neutrophils, classical monocytes and dendritic cells. Int Immunol. 24: 613-623, 2012.

Kagiyama Y, Kitaura J, Togami K, Uchida T, Inoue D, Matsukawa T, Izawa K, Kawabata KC, Komeno Y, Oki T, Nakahara F, Sato K, Aburatani H, Kitamura T: Upregulation of CD200R1 in lineage-negative leukemic cells is characteristic of AML1-ETO-positive leukemia in mice. Int J Hematol. 96: 638-648, 2012.

Enomoto Y, Kitaura J, Shimanuki M, Kato N, Nishimura K, Takahashi M, Nakakuma H, Kitamura T, Sonoki T: MicroRNA-125b-1 accelerates a C-terminal mutant of C/EBPα (C/EBPα-C(m))-induced myeloid leukemia. Int J Hematol. 96: 334-341, 2012.

Kashiwakura JC, Ando T, Matsumoto K, Kimura M, Kitaura J, Matho MH, Zajonc DM, Ozeki T, Ra C, MacDonald SM, Siraganian RP, Broide DH, Kawakami Y, Kawakami T: Histamine-releasing factor has a proinflammatory role in mouse models of asthma and allergy. J Clin Invest. 122: 218-228, 2012.

Oki T, Kitaura J, Watanabe-Okochi N, Nishimura K, Maehara A, Uchida T, Komeno Y, Nakahara F, Harada Y, Sonoki T, Harada H, Kitamura T: Aberrant expression of RasGRP1 cooperates with gain-of-function NOTCH1 mutations in T-cell leukemogenesis. Leukemia. 26: 1038-1045, 2012.

Nakamura M, Kitaura J, Enomoto Y, Lu Y, Nishimura K, Isobe M, Ozaki K, Komeno Y, Nakahara F, Oki T, Kume H, Homma Y, Kitamura T: Transforming growth factor-β-stimulated clone-22 is a negative-feedback regulator of Ras / Raf signaling: Implications for tumorigenesis. Cancer Sci. 103: 26-33, 2012.

Shibata-Minoshima F, Oki T, Doki N, Nakahara F, Kageyama S, Kitaura J, Fukuoka J, Kitamura T: Identification of RHOXF2 (PEPP2) as a cancer-promoting gene by expression cloning. Int J Oncol. 40: 93-98, 2012.

Doki N, Kitaura J, Uchida T, Inoue D, Kagiyama Y, Togami K, Isobe M, Ito S, Maehara A, Izawa K, Kato N, Oki T, Harada Y, Nakahara F, Harada H, Kitamura T: Fyn is not essential for Bcr-Abl-induced leukemogenesis in mouse bone marrow transplantation models. Int J Hematol. 95: 167-175, 2012.

Hirota T, Takahashi A, Kubo M, Tsunoda T, Tomita K, Sakashita M, Yamada T, Fujieda S, Tanaka S, Doi S, Miyatake A, Enomoto T, Nishiyama C, Nakano N, Maeda K, Okumura K, Ogawa H, Ikeda S, Noguchi E, Sakamoto T, Hizawa N, Ebe K, Saeki H, Sasaki T, Ebihara T, Amagai M, Takeuchi S, Furue M, Nakamura Y, Tamari M: Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population. Nat Genet. 44: 1222-1226, 2012.

Kamijo M, Nishiyama C, Takagi A, Nakano N, Hara M, Ikeda S, Okumura K, Ogawa H: Cyclooxygenase-2 inhibition restores ultraviolet B-induced downregulation of ATP2A2/SERCA2 in keratinocytes: possible therapeutic approach of cyclooxygenase-2 inhibition for treatment of Darier disease. Br J Dermatol. 166: 1017-1022, 2012.

Kitamura N, Yokoyama H, Yashiro T, Nakano N, Nishiyama M, Kanada S, Fukai T, Hara M, Ikeda S, Ogawa H, Okumura K, Nishiyama C: Role of PU.1 in MHC class II expression through transcriptional regulation of class II transactivator pI in dendritic cells. J Allergy Clin Immunol. 129: 814-824, 2012.

Kawakami T, Ando T, Kawakami Y: HRF-Interacting Molecules. The Open Allergy Journal. 5: 41-46, 2012.

Enomoto Y, Kitaura J, Hatakeyama K, Watanuki J, Akasaka T, Kato N, Shimanuki M, Nishimura K, Takahashi M, Taniwaki M, Haferlach C, Siebert R, Dyer MJ, Asou N, Aburatani H, Nakakuma H, Kitamura T, Sonoki T: Eμ/miR-125b transgenic mice develop lethal B-cell malignancies. Leukemia. 25: 1849-1856, 2011.

Kato N, Kitaura J, Doki N, Komeno Y, Watanabe-Okochi N, Togami K, Nakahara, F, Oki T, Enomoto Y, Fukuchi Y, Nakajima H, Harada Y, Harada H, Kitamura T: Two types of C/EBPα mutations play distinct but collaborative roles in leukemogenesis: Lessons from clinical data and BMT models. Blood. 117: 221-233, 2011.

Tomimori Y, Kawakami Y, McCausland MM, Ando T, Koriazova L, Kato S, Kawakami T, Crotty S: Protective murine and human monoclonal antibodies against eczema vaccinatum, Antivir Ther. 16: 67-75, 2011.

Xiao W, Kashiwakura J, Hong H, Yasudo H, Ando T, Maeda-Yamamoto M, Wu D, Kawakami Y, Kawakami T: Phospholipase C-beta3 regulates FcεRI-mediated mast cell activation by recruiting the protein phosphatase SHP-1. Immunity 34, 893-904, 2011.

Nakano N, Nishiyama C, Yagita H, Koyanagi A, Ogawa H, Okumura K: Notch1-mediated signaling induces MHC class II expression through activation of class II transactivator promoter III in mast cells. J Biol Chem. 286: 12042-12048, 2011.

Kanada S, Nishiyama C, Nakano N, Suzuki R, Maeda K, Hara M, Kitamura N, Ogawa H, Okumura K: Critical role of transcription factor PU.1 in the expression of CD80 and CD86 on dendritic cells. Blood. 117: 2211-2222, 2011.

Yasudo H, Ando T, Xiao W, Kawakami Y, Kawakami T: Short Stat5-interacting peptide derived from phospholipase C-beta3 inhibits hematopoietic cell proliferation and myeloid differentiation, PLoS One 6: e24995, 2011.

Enomoto Y, Yamanishi Y, Izawa K, Kaitani A, Takamatsu R, Kajikawa M, Takai T, Kitamura T, Kitaura J: Characterization of leukocyte mono-immunoglobulin-like receptor 7 (LMIR7)/CLM-3 as an activating receptor: its similarities to and differences from LMIR4/CLM-5. J Biol Chem. 285: 35274-35283, 2010.

Yamanishi Y, Kitaura J, Izawa K, Kaitani A, Komeno Y, Nakamura M, Yamazaki S, Enomoto Y, Oki T, Akiba H, Abe T, Komori T, Morikawa Y, Kiyonari H, Takai T, Okumura K, Kitamura T: TIM1 is an endogenous ligand for LMIR5/CD300b: LMIR5 deficiency ameliorates mouse kidney ischemia/reperfusion injury. J Exp Med. 207: 1501-1511, 2010.

Komeno Y, Kitaura J, Watanabe-Okochi N, Kato N, Oki T, Nakahara F, Harada Y, Harada H, Shinkura R, Nagaoka H, Hayashi Y, Honjo T, Kitamura T: AID-induced T-lymphoma or B-leukemia/lymphoma in a mouse BMT model. Leukemia. 24: 1018-1024, 2010.

Minobe K, Ono R, Matsumine A, Shibata-Minoshima F, Izawa K, Oki T, Kitaura J, Iino T, Takita J, Iwamoto S, Hori H, Komada Y, Uchida A, Hayashi Y, Kitamura, T, Nosaka T: Expression of ADAMTS4 in Ewing’s sarcoma. Int J Oncol. 37: 569-581, 2010.

Nakahara F, Sakata-Yanagimoto M, Komeno Y, Kato N, Haraguchi K, Kumano K, Harada Y, Harada H, Kitaura J, Ogawa S, Kurokawa M, Kitamura T, Chiba S: Hes1 immortalizes committed progenitors and plays a role in blastic crisis of chronic myelogenous leukemia. Blood. 115: 2872-2881, 2010.

Poderycki M, Tomimori Y, Ando T, Xiao W, Maeda-Yamamoto M, Sauer K, Kawakami Y, Kawakami T: A minor catalytic activity of Src family kinases is sufficient for maximal activation of mast cells via the high-affinity IgE receptor. J Immunol. 184, 84-93, 2010.

Xiao W, Ando T, Wang HY, Kawakami Y, Kawakami T: Lyn- and PLC-beta3-dependent regulation of SHP-1 phosphorylation controls Stat5 activity and myelomonocytic leukemia-like disease. Blood 116, 6003-6013, 2010.

Shimokawa N, Nishiyama C, Nakano N, Maeda K, Suzuki R, Hara M, Fukai T, Tokura T, Miyajima H, Nakao A, Ogawa H, Okumura K: Suppressive effects of transcription factor GATA-1 on cell type-specific gene expression in dendritic cells. Immunogenetics. 62: 421-429, 2010.

Wang QH, Nishiyama C, Nakano N, Kanada S, Hara M, Kitamura N, Shimokawa N, Lu CL, Ogawa H, Okumura K: Opposite effects of Trichostatin A on activation of mast cells by different stimulants. FEBS Lett. 584: 2315-2320, 2010.

Oki T, Eto K, Izawa K, Yamanishi Y, Inagaki N, Frampton J, Kitamura T, Kitaura J: Evidence that integrin alphaIIbbeta3-dependent interaction of mast cells with fibrinogen exacerbates chronic inflammation. J Biol Chem. 284: 31463-31472, 2009.

Izawa K, Kitaura J, Yamanishi Y, Matsuoka T, Kaitani A, Sugiuchi M, Takahashi M, Maehara A, Enomoto Y, Oki T, Takai T, Kitamura T: An activating and inhibitory signal from an inhibitory receptor LMIR3/CLM-1: LMIR3 augments lipopolysaccharide response through association with FcRgamma in mast cells. J Immunol. 183: 925-936, 2009.

Watanabe-Okochi N, Oki T, Komeno Y, Kato N, Yuji K, Ono R, Harada Y, Harada H, Hayashi Y, Nakajima H, Nosaka T, Kitaura J, Kitamura T: Possible involvement of RasGRP4 in leukemogenesis. Int J Hematol. 89: 470-481, 2009.

Miyazaki K, Yamasaki N, Oda H, Kuwata T, Kanno Y, Miyazaki M, Komeno Y, Kitaura J, Honda Z, Warming S, Jenkins NA, Copeland NG, Kitamura T, Nakamura, Honda H: Enhanced expression of p210BCR/ABL and aberrant expression of Zfp423/ZNF423 induce blast crisis of chronic myelogenous leukemia. Blood. 113: 4702-4710, 2009.

Komeno Y, Kitaura J, Kitamura T: Molecular bases of myelodysplastic　syndromes:　lessons from animal models. J Cell Physiol. 219: 529-534, 2009.

Potaczek DP, Wang QH, Sanak M, Tokura T, Matsuda H, Dziedzina S, Nakano N, Hara M, Ogawa H, Szczeklik A, Okumura K, Nishiyama C: Interaction of functional FCER2 promoter polymorphism and phenotype-associated haplotypes. Tissue Antigens. 74: 534-8, 2009.

Potaczek DP, Maeda K, Wang QH, Nakano N, Kanada S, Stepien E, Branicka A, Fukai T, Hara M, Tokura T, Ogawa H, Undas A, Okumura K, Nishiyama C: FcepsilonRIalpha gene -18483A>C polymorphism affects transcriptional activity through YY1 binding. Immunogenetics. 61: 649-655, 2009.

Fukai T, Nishiyama C, Kanada S, Nakano N, Hara M, Tokura T, Ikeda S, Ogawa H, Okumura K: Involvement of PU.1 in the transcriptional regulation of TNF-alpha. Biochem Biophys Res Commun. 388: 102-106, 2009.

Ito T, Nishiyama C, Nakano N, Nishiyama M, Usui Y, Takeda K, Kanada S, Fukuyama K, Akiba H, Tokura T, Hara M, Tsuboi R, Ogawa H, Okumura K: Roles of PU.1 in monocyte- and mast cell-specific gene regulation: PU.1 transactivates CIITA pIV in cooperation with IFN-gamma. Int Immunol. 21: 803-816, 2009.

Nakano N, Nishiyama C, Yagita H, Koyanagi A, Akiba H, Chiba S, Ogawa H, Okumura K: Notch signaling confers antigen-presenting cell functions on mast cells. J Allergy Clin Immunol. 123: 74-81, 2009

Kawakami Y, Tomimori Y, Yumoto K, Hasegawa S, Ando T, Tagaya Y, Crotty S, Kawakami T: Inhibition of NK cell activity by IL-17 allows vaccinia virus to induce severe skin lesions in a mouse model of eczema vaccinatum, J Exp Med. 206, 1219-1225, 2009.

Kawakami T, Ando T, Kimura M, Wilson BS, Kawakami Y: Mast cells in atopic dermatitis. Curr Opin Immunol. 21, 666-678, 2009.

Watanabe-Okochi N, Kitaura J, Ono R, Harada H, Harada Y, Komeno Y, Nakajima H, Nosaka T, Inaba T, Kitamura T: AML1 mutations induced MDS and MDS/AML in a mouse BMT model. Blood. 111: 4297-4308, 2008.

Yamanishi Y, Kitaura J, Izawa K, Matsuoka T, Oki T, Lu Y, Shibata F, Yamazaki S, Kumagai H, Nakajima H, Maeda-Yamamoto M, Tybulewicz VL, Takai T, Kitamura T: Analysis of mouse LMIR5/CLM-7 as an activating receptor: differential regulation of LMIR5/CLM-7 in mouse versus human cells. Blood. 111: 688-698, 2008.

Kashiwakura J, Xiao W, Kitaura J, Kawakami Y, Maeda-Yamamoto M, Pfeiffer JR, Wilson BS, Blank U, Kawakami T: Pivotal advance: IgE accelerates in vitro development of mast cells and modifies their phenotype. J Leukoc Biol. 84: 357-367, 2008.

Niwa Y, Nishiyama C, Nakano N, Kamei A, Kato H, Kanada S, Ikeda S, Ogawa H, Okumura K: Opposite effects of PU.1 on mast cell stimulation. Biochem Biophys Res Commun. 375: 95-100, 2008.

Wang QH, Nishiyama C, Nakano N, Shimokawa N, Hara M, Kanada S, Ogawa H, Okumura K: Suppressive effect of Elf-1 on FcepsilonRI alpha-chain expression in primary mast cells. Immunogenetics. 60: 557-563, 2008.

Nakano N, Nishiyama C, Tokura T, Nagasako-Akazome Y, Ohtake Y, Okumura K, Ogawa H: Procyanidin C1 from apple extracts inhibits Fc epsilon RI-mediated mast cell activation Int Arch Allergy Immunol. 147: 213-221, 2008.

Kanada S, Nakano N, Potaczek DP, Maeda K, Shimokawa N, Niwa Y, Fukai T, Sanak M, Szczeklik A, Yagita H, Okumura K, Ogawa H, Nishiyama C: Two different transcription factors discriminate the -315C>T polymorphism of the Fc epsilon RI alpha gene: binding of Sp1 to -315C and of a high mobility group-related molecule to -315T. J Immunol. 180: 8204-8210, 2008.

Ng W, Nishiyama C, Mizoguchi M, Nakano N, Suga Y, Ikeda S, Itoh S, Kinoshita K, Okumura K, Ogawa H: Human umbilical cord epithelial cells express Notch1: implications for its epidermal-like differentiation. J Dermatol Sci. 49: 143-152, 2008.

Ishikawa Y, Tokura T, Nakano N, Hara M, Niyonsaba F, Ushio H, Yamamoto Y, Tadokoro T, Okumura K, Ogawa H: Inhibitory effect of honeybee-collected pollen on mast cell degranulation in vivo and in vitro. J Med Food. 11: 14-20, 2008.

Takagi A, Nishiyama C, Maeda K, Tokura T, Kawada H, Kanada S, Niwa Y, Nakano N, Mayuzumi N, Nishiyama M, Ikeda S, Okumura K, Ogawa H: Role of Sp1 in transcription of human ATP2A2 gene in keratinocytes. J Invest Dermatol. 128: 96-103, 2008

Kitaura J, Kawakami Y, Maeda-Yamamoto M, Horejsi V, Kawakami T: Dysregulation of Src family kinases in mast cells from epilepsy-resistant ASK versus epilepsy-prone EL mice. J Immunol. 178: 455-462, 2007.

Izawa K, Kitaura J, Yamanishi Y, Matsuoka T, Oki T, Shibata F, Kumagai H, Nakajima H, Maeda-Yamamoto M, Hauchins JP, Tybulewicz VL, Takai T, Kitamura T: Functional analysis of activating receptor LMIR4 as a counterpart of inhibitory receptor LMIR3. J Biol Chem. 282: 17997-18008, 2007.

Lu Y, Kitaura J, Oki T, Komeno Y, Ozaki K, Kiyono M, Kumagai H, Nakajima H, Nosaka T, Aburatani H, Kitamura T: Identification of TSC-22 as a potential tumor suppressor that is upregulated by Flt3-D835V but not Flt3-ITD. Leukemia. 21: 2246-2257, 2007.

Hong H, Kitaura J, Xiao W, Horejsi V, Ra C, Lowell CA, Kawakami Y, Kawakami T: The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn. Blood. 110: 2511-2519, 2007.

Nakano N, Nishiyama C, Kanada S, Niwa Y, Shimokawa N, Ushio H, Nishiyama M, Okumura K, Ogawa H: Involvement of mast cells in IL-12/23 p40 production is essential for survival from polymicrobial infections. Blood. 109: 4846-4855, 2007.

Niyonsaba F, Ushio H, Nakano N, Ng W, Sayama K, Hashimoto K, Nagaoka I, Okumura K, Ogawa H: Antimicrobial peptides human beta-defensins stimulate epidermal keratinocyte migration, proliferation and production of proinflammatory cytokines and chemokines. J Invest Dermatol. 127: 594-604, 2007.

Kawakami Y, Inagaki N, Salek-Ardakani S, Kitaura J, Tanaka H, Nagao K, Kawakami Y, Xiao W, Nagai H, Croft M, Kawakami T: Regulation of dendritic cell maturation and function by Bruton’s tyrosine kinase via IL-10 and Stat3. Proc Natl Acad Sci U S A. 103: 153-158, 2006.

Oki T, Kitaura J, Eto K, Lu Y, Maeda-Yamamoto M, Inagaki N, Nagai H, Yamanishi Y, Nakajima H, Kumagai H, Kitamura T: Integrin alphaIIbbeta3 induces the adhesion and activation of mast cells through interaction with fibrinogen. J Immunol. 176: 52-60, 2006.

Kawakami T, Kitaura J: Mast cell survival and activation by IgE in the absence of antigen: a consideration of the biologic mechanisms and relevance. J Immunol. 175: 4167-4173, 2005.

Kitaura J, Eto K, Kinoshita T, Kawakami Y, Leiteges M, Lowell CA, Kawakami T: Regulation of highly cytokinergic IgE-induced mast cell adhesion by Src, Syk, Tec, and protein kinase C family kinases. J Immunol. 174: 4495-4504, 2005.

Kitaura J, Kinoshita T, Matsumoto M, Chung S, Kawakami Y, Leiteges M, Wu D, Lowell CA, Kawakami T: IgE- and IgE+Ag-mediated mast cell migration in an autocrine/paracrine fashion. Blood. 105: 3222-3229, 2005.

Xiao W, Nishimoto H, Hong H, Kitaura J, Nunomura S, Maeda-Yamamoto M, Kawakami Y, Lowell CA, Ra C, Kawakami T: Positive and negative regulation of mast cell activation by Lyn via the FcepsilonRI. J Immunol. 175: 6885-6892, 2005.

Nakano N, Nakao A, Uchida T, Shirasaka N, Yoshizumi H, Okumura K, Tsuboi R, Ogawa H: Effects of arachidonic acid analogs on FcepsilonRI-mediated activation of mast cells. Biochim Biophys Acta. 1738: 19-28, 2005.

Tokura T, Nakano N, Ito T, Matsuda H, Nagasako-Akazome Y, Kanda T, Ikeda M, Okumura K, Ogawa H, Nishiyama C: Inhibitory effect of polyphenol-enriched apple extracts on mast cell degranulation in vitro targeting the binding between IgE and FcepsilonRI. Biosci Biotechnol Biochem. 69: 1974-1977, 2005.

Nakano N, Nakao A, Ishidoh K, Tsuboi R, Kominami E, Okumura K, Ogawa H: CDK5 regulates cell-cell and cell-matrix adhesion in human keratinocytes. Br J Dermatol. 153: 37-45, 2005.

Nishiyama C, Ito T, Nishiyama M, Masaki S, Maeda K, Nakano N, Ng W, Fukuyama K, Yamamoto M, Okumura K, Ogawa H: GATA-1 is required for expression of Fc{epsilon}RI on mast cells: analysis of mast cells derived from GATA-1 knockdown mouse bone marrow. Int Immunol. 17: 847-856, 2005.

Kawada H, Nishiyama C, Takagi A, Tokura T, Nakano N, Maeda K, Mayuzumi N, Ikeda S, Okumura K, Ogawa H: Transcriptional regulation of ATP2C1 gene by Sp1 and YY1 and reduced function of its promoter in Hailey-Hailey disease keratinocytes. J Invest Dermatol. 124:1206-1214, 2005.

Nakano N, Nishiyama C, Masuoka N, Nishiyama M, Yamane H, Okumura K, Ogawa H: Analysis of PU.1/ICSBP (IRF-8) complex formation with various PU.1 mutants: molecular cloning of rat Icsbp (Irf-8) cDNA. Immunogenetics. 56: 871-877, 2005.

Kitaura J, Xiao W, Maeda-Yamamoto M, Kawakami Y, Lowell CA, Kawakami T: Early divergence of Fc epsilon receptor I signals for receptor up-regulation and internalization from degranulation, cytokine production, and survival. J Immunol. 173: 4317-4323, 2004.

Kawakami Y, Nishimoto H, Kitaura J, Maeda-Yamamoto M, Kato RM, Littman DR, Leitges M, Rawlings DJ, Kawakami T: Protein kinase C betaII regulates Akt phosphorylation on Ser-473 in a cell type- and stimulus-specific fashion. J Biol Chem. 279: 47720-47725, 2004.

Maeda-Yamamoto M, Inagaki N, Kitaura J, Chikumoto T, Kawahara H, Kawakami Y, Sano M, Miyase T, Tachibana H, Nagai H, Kawakami T: O-methylated catechins from tea leaves inhibit multiple protein kinases in mast cells. J Immunol. 172: 4486-4492, 2004.

Nishiyama C, Akizawa Y, Nishiyama M, Tokura T, Kawada H, Mitsuishi K, Hasegawa M, Ito T, Nakano N, Okamoto A, Takagi A, Yagita H, Okumura K, Ogawa H: Polymorphisms in the Fc epsilon RI beta promoter region affecting transcription activity: a possible promoter-dependent mechanism for association between Fc epsilon RI beta and atopy. J Immunol. 173: 6458-6464, 2004.

Jin L, Nakao A, Nakayama M, Yamaguchi N, Kojima Y, Nakano N, Tsuboi R, Okumura K, Yagita H, Ogawa H: Induction of RANTES by TWEAK/Fn14 interaction in human keratinocytes. J Invest Dermatol. 122: 1175-1179, 2004.

Prapars M, Nakao A, Nakano N, Jin L, Ogawa H: Expression of phosphorylated Smad2 in normal human epidermis. J Dermatol Sci. 34: 54-55, 2004.

Kitaura J, Song J, Tsai M, Asai K, Maeda-Yamamoto M, Mocsai A, Kawakami Y, Liu FT, Lowell CA, Barisas BG, Galli SJ, Kawakami T: Evidence that IgE molecules mediate a spectrum of effects on mast cell survival and activation via aggregation of the FcepsilonRI. Proc Natl Acad Sci U S A. 100: 12911-12916, 2003.

Kawakami Y, Kitaura J, Yao L, McHenry RW, Kawakami Y, Newton AC, Kang S, Kato RM, Leitges M, Rawlings DJ, Kawakami T: A Ras activation pathway dependent on Syk phosphorylation of protein kinase C. Proc Natl Acad Sci U S A. 100: 9470-9475, 2003.

Kawakami T, Kawakami Y, Kitaura J: Protein kinase C beta (PKC beta): normal functions and diseases. J Biochem. 132: 677-682, 2002.

Mócsai A, Zhang H, Jakus Z, Kitaura J, Kawakami T, Lowell CA: G-protein-coupled receptor signaling in Syk-deficient neutrophils and mast cells. Blood. 101: 4155-4163, 2003.

Asai K, Kitaura J, Kawakami Y, Yamagata N, Tsai M, Carbone DP, Liu FT, Galli SJ, Kawakami T: Regulation of mast cell survival by IgE. Immunity. 14: 791-800, 2001.

Kang SW, Wahl MI, Chu J, Kitaura J, Kawakami Y, Kato RM, Tabuchi R, Tarakhovsky A, Kawakami T, Turck CW, Witte ON, Rawlings DJ: PKCbeta modulates antigen receptor signaling via regulation of Btk membrane localization. EMBO J. 20: 5692-5702, 2001.

Uchida T, Nakao A, Nakano N, Kuramasu A, Saito H, Okumura K, Ra C, Ogawa H: Identification of Nash1, a novel protein containing a nuclear localization signal, a sterile alpha motif, and an SH3 domain preferentially expressed in mast cells. Biochem. Biophys Res Commun. 288: 137-141, 2001.

Nakano N, Shirasaka N, Kurihara M, Takamatsu M, Murakami T, Yoshizumi H, Tsuboi R, Ogawa H: Competitive incorporation of arachidonic acid analogs by cultured rat keratinocytes. J Nutr Sci Vitaminol (Tokyo). 47: 69-77, 2001.

Kawakami Y, Kitaura J, Hartman SE, Lowell CA, Siraganian RP, Kawakami T: Regulation of protein kinase CbetaI by two protein-tyrosine kinases, Btk and Syk. Proc Natl Acad Sci U S A. 97: 7423-7428, 2000.

Kawakami Y, Kitaura J, Satterthwaite AB, Kato RM, Asai K, Hartman SE, Maeda-Yamamoto M, Lowell CA, Rawlings DJ, Witte ON, Kawakami T: Redundant and opposing functions of two tyrosine kinases, Btk and Lyn, in mast cell activation. J Immunol. 165: 1210-1219, 2000.

Kitaura J, Asai K, Maeda-Yamamoto M, Kawakami Y, Kikkawa U, Kawakami T: Akt-dependent cytokine production in mast cells. J Exp Med. 192: 729-740, 2000.

Kawakami Y, Hartman SE, Kinoshita E, Suzuki H, Kitaura J, Yao L, Inagaki N, Franco A, Hata D, Maeda-Yamamoto M, Fukamachi H, Nagai H, Kawakami T: Terreic acid, a quinone epoxide inhibitor of Bruton’s tyrosine kinase. Proc Natl Acad Sci U S A. 96: 2227-2232, 1999.

Kitaura J, Miki Y, Kato H, Sakakihara Y, Yanagisawa M: Hyperinsulinaemic hypoglycaemia associated with persistent hyperammonaemia. Eur J Pediatr. 158: 410-413, 1999.

Kawakami Y, Kitaura J, Hata D, Yao L, Kawakami T: Functions of Bruton’s tyrosine kinase in mast and B cells. J Leukoc Biol. 65: 286-290, 1999.

Hata D, Kitaura J, Hartman SE, Kawakami Y, Yokota T, Kawakami T: Bruton’s tyrosine kinase-mediated interleukin-2 gene activation in mast cells. Dependence on the c-Jun N-terminal kinase activation pathway. J Biol Chem. 273: 10979-10987, 1998.