*: Corresponding author（責任著者）
2022-2023
Kimitsu T, Kamijo S, Yoshimura T, Masutani Y, Shimizu S, Takada K, Suchiva P, Ogawa H, Okumura K, Ikeda S, Takai T*. Antigen protease activity on intact or tape-stripped skin induces acute itch and T helper sensitization leading to airway eosinophilia in mice. JID innov. 4:100239 (2023). [査読有]
Yoshimura T, Kamijo S, Ichikawa S, Kimitsu T, Masutani Y, Shimizu S, Takada K, Ogawa T, Tominaga M, Takamori K, Ogawa H, Okumura K, Ikeda S, Takai T*. Antigen protease activity with a detergent induces severe skin inflammation with itch and robust T helper 17/T helper 22 differentiation in mice. J Invest Dermatol. 143:2314-2318.e3 (2023). [査読有]
Masutani Y, Takai T*, Kamijo S, Kimitsu T, Yoshimura T, Ichikawa S, Shimizu S, Ogawa T, Takada K, Tominaga M, Suto H, Takamori K, Ogawa H, Okumura K, Ikeda S. Skin treatment with detergent induces dermatitis with H1-antihistamine-refractory itch and upregulates IL-4 and Th17/Th22 cytokine gene expression in C57BL/6 mice. Int Arch Allergy Immunol 183:1040-1049 (2022). [査読有]
高井敏朗*. アレルゲンのプロテアーゼ活性が促進する炎症と感作. アレルギー（日本アレルギー学会誌）72:1198-1204 (2023). [Review]
高井敏朗*, 上條清嗣. アレルゲンのプロテアーゼ活性と免疫応答. 臨床免疫・アレルギー科, 77:405-410 (2022). [Review]
2021
Kamijo S, Hara M, Suzuki M, Nakae S, Ogawa H, Okumura K, Takai T*. Innate IL-17A enhances IL-33-independent skin eosinophilia and IgE response on subcutaneous papain sensitization. J Invest Dermatol 141:105-113.e14 (2021) [査読有]
Kunimine S, Takai T*, Kamijo S, Maruyama N, Kimitsu T, Masutani Y, Yoshimura T, Suchiva P, Shimizu S, Ogawa H, Okumura K, Ikeda S. Epicutaneous vaccination with protease inhibitor-treated papain prevents papain-induced Th2-mediated airway inflammation without inducing Th17 in mice. Biochem Biophys Res Commun 546:192-199 (2021) [査読有]
Suchiva P, Takai T*, Kamijo S, Maruyama N, Yokomizo T, Sugimoto Y, Okumura K, Ikeda S, Ogawa H. Inhibition of both cyclooxygenase-1 and -2 promotes epicutaneous Th2 and Th17 sensitization and allergic airway inflammation on subsequent airway exposure to protease allergen in mice. Int Arch Allergy Immunol. 182:788-799 (2021) [査読有]
Ogasawara A*, Yuki T, Takai T, Yokozeki K, Katagiri A, Takahashi Y, Yokozeki H, Basketter D, Sakaguchi H. Epicutaneous challenge with protease allergen requires its protease activity to recall TH2 and TH17/TH22 responses in mice pre-sensitized via distant skin. J Immunotoxicol. 18:118-126 (2021). [査読有]
Takai T*. Allergens in modern society: 2021. Allergol Int. 70:279-280 (2021). [Editorial]
高井敏朗*. アレルゲンの基礎〜抗原から免疫学まで〜. アレルギー（日本アレルギー学会誌）70:255-260 (2021) [Review]
上條清嗣*, 原むつ子, 鈴木麻友, 中江進, 小川秀興, 奧村康, 高井敏朗*. パパインの皮下感作におけるIL-17AによるIL-33非依存性好酸球炎症とIgE反応の増強. 臨床免疫・アレルギー科, 75:299-306 (2021) [Review]
2019-2020
Maruyama N, Takai T*, Kamijo S, Suchiva P, Takeshige T, Suzuki M, Hara M, Matsuno K, Harada S, Narada N, Nakae S, Sudo K, Okuno T, Yokomizo T, Ogawa H, Okumura K, Ikeda S. Cyclooxygenase inhibition in mice hightens adaptive-and innate-type responses against inhaled protease allergen and IL-33. Allergy, 74: 2237-2240 (2019) [査読有]
高井敏朗*. アレルゲンのアジュバント作用. 日本職業・環境アレルギー学会雑誌 26:1-8 (2019) [Review] [査読有]
高井敏朗*. 2 病態の新しい考え方 7) ダニの関与．皮膚科の臨床 (増刊 変わりつつあるアトピー性皮膚炎の常識-最新の知識と治療の極意-) 61:759-764 (2019) [Review]
高井敏朗*, 上條清嗣. アレルゲンと自然免疫. 臨床免疫アレルギー科, 73:160-167 (2020) [Review]
2017-2018
Nishioka I, Takai T*, Maruyama N, Kamijo S, Suchiva P, Suzuki M, Kunimine S, Ochi H, Shimura S, Sudo K, Ogawa H, Okumura K, Ikeda S. Airway inflammation after epicutaneous sensitization of mice requires protease activity of low-dose allergen inhalation. J Allergy Clin Immunol 141:2271-2273.e7 (2018) [査読有]
Ochi H, Takai T*, Shimura S, Maruyama N, Nishioka I, Kamijo S, Iida H, Nakae S, Ogawa H, Okumura K, Ikeda S. Skin treatment with detergent promotes protease allergen-dependent epicutaneous sensitization in a manner different from tape stripping in mice. J Invest Dermatol 137:1578-1582 (2017) [査読有]
高井敏朗*. ダニ抗原について. 最新醫學別冊 診断と治療ABC127「アレルギー性鼻炎」 pp128-19 (2017) [Review]
高井敏朗*, 清村咲子, 飯田秀雄, 丸山奈津子, 越智啓乃, 上條清嗣, 西岡いずみ, 原むつ子, 松田彰, 斎藤博久, 中江進, 小川秀興, 奧村康, 池田志斈. アレルゲンのプロテアーゼ活性と機械的な皮膚バリア損傷はマウスにおいて経皮的アレルゲン感作を増強する. 臨床免疫・アレルギー科68:515-522 (2017) [Review]
高井敏朗*. 免疫学・アレルギー学の基礎：アレルゲンと感作・発症の機序. 第51会日本アレルギー学会専門医教育セミナーテキストpp1-6. (2017)
2016
Shimura S, Takai T*, Iida H, Maruyama N, Ochi H, Kamijo S, Nishioka I, Hara M, Matsuda A, Saito H, Nakae S, Ogawa H, Okumura K, Ikeda S. Epicutaneous allergic sensitization by cooperation between allergen protease-activity and mechanical skin barrier damage in mice. J Invest Dermatol 136:1408-17 (2016) [査読有]
Kamijo S, Nunomura S, Ra C, Kanaguchi Y, Suzuki Y, Ogawa H, Okumura K, Takai T*. Innate basophil IL-4 responses against allergens, endotoxin, and cytokines require the Fc receptor gamma-chain. J Allergy Clin Immunol 137:1613-1615.e2 (2016) [査読有]
Kamijo S, Suzuki M, Hara M, Shimura S, Ochi H, Maruyama N, Matsuda A, Saito H, Nakae S, Suto H, Ichikawa S, Ikeda S, Ogawa H, Okumura K, Takai T*. Subcutaneous allergic sensitization to protease allergen is dependent on mast cells but not IL-33: Distinct mechanisms between subcutaneous and intranasal routes. J Immunol 196:3559-69 (2016) [査読有]
Suzuki M, Hara M, Ichikawa S, Kamijo S, Nakazawa T, Hatanaka H, Akiyama K, Ogawa H, Okumura K, Takai T*. Presensitization to Ascaris antigens promotes induction of mite-specific IgE upon mite antigen inhalation in mice. Allergol Int 65:44-51 (2016) [査読有]
高井敏朗*. 環境アレルゲン. 日本医師会雑誌特別号「アレルギー疾患の全て」145:S55-S56 (2016) [Review]
高井敏朗*. 専門医のためのアレルギー講座: アレルゲンとその修飾因子. アレルギー 65:159-165 (2016) [Review]
高井敏朗*. 家塵ダニアレルゲンの性状と標準化. 喘息・アレルギー 29:15-19 (2016) [Review]
高井敏朗*, 上條清嗣, 布村聡, 羅智靖, 小川秀興, 奧村康. 好塩基球の自然免疫応答によるIL-4産生のFc受容体γ鎖依存性 臨床免疫・アレルギー科 66:371-374 (2016) [Review]
2015
Nishikado H, Fujimura T, Taka H, Mineki R, Ogawa H, Okumura K, Takai T*, Cysteine protease antigens cleave CD123, the alfa subunit of murine IL-3 receptor, on basophils and suppress IL-3-mediated basophil expansion. Biochem Biophys Res Commun, 460(2):261-6 (2015) [査読有]
Takai T, Okamoto Y, Okubo K, Nagata M, Sakaguchi M, Fukutomi Y, Saito A, Yasueda H, Masuyama K*. Japanese Society of Allergology task force report on standardization of house dust mite allergen vaccines–secondary publication. Allergol Int 64:181-186 (2015) [査読有]
Pichler U, Hauser M, Wolf M, Bernardi ML, Gadermaier G, Weiss R, Ebner C, Yokoi H, Takai T, Didierlaurent A, Rafaiani C, Briza P, Mari A, Behrendt H, Wallner M, Ferreira F*. Pectate lyase pollen allergens: Sensitization profiles and cross-reactivity pattern. PLoS One. 10:e0120038 (2015) [査読有]
Takai T*. Immunotherapy to treat allergies: Recent advances and future prospects. Juntendo Med J 61:597-600 (2015) [Review] [査読有]
Takai T, Izuhara K*. Allergens in modern society: Updated catalogs and future prospects. Allergol Int 64:293-294 (2015) [Editorial]
高井敏朗*. IL-33とアレルゲン. 医学のあゆみ :252:1226-1232 (2015) [Review]
2014
Iida H, Takai T*, Hirasawa Y, Kamijo S, Shimura S, Ochi H, Nishioka I, Maruyama N, Ogawa H, Okumura K, Ikeda S. Epicutaneous administration of papain induces IgE and IgG responses in a cysteine protease activity-dependent manner. Allergol Int 63:319-226 (2014) [査読有]
Zhang C, Ohno T, Kang S, Takai T, Azuma M*. Repeated antigen painting and sublingual immunotherapy in mice convert sublingual dendritic cell subsets. Vaccine. 32:5669-76 (2014) [査読有]
Takai T*, Chen X, Xie Y, Vu AT, Le TA, Kinoshita H, Kawasaki J, Kamijo S, Hara M, Ushio H, Baba T, Hiramatsu K, Ikeda S, Ogawa H, Okumura K. TSLP expression induced via Toll-like receptor pathways in human keratinocytes. Methods Enzymol 535:371-387 (2014) [Book Chapter][Review][査読有]
高井敏朗, 岡本美孝, 大久保公裕, 永田真, 阪口雅弘, 福冨友馬, 齋藤明美, 安枝浩, 増山敬祐*. ダニアレルゲンワクチン標準化に関する日本アレルギー学会タスクフォース報告. アレルギー 63:1229-1239 (2014) [査読有]
高井敏朗*. 環境アレルゲン解析の進歩. 小児科診療77:1241-1247 (2014) [Review]
2013
Kamijo S, Takeda H, Tokura T, Suzuki M, Inui K, Hara M, Matsuda H, Matsuda A, Oboki K, Ohno T, Saito H, Nakae S, Sudo K, Suto H, Ichikawa S, Ogawa H, Okumura K, Takai T*. IL-33-mediated innate response and adaptive immune cells contribute to maximum responses of protease allergen-induced allergic airway inflammation. J Immunol 190:4489-99 (2013) [査読有]
Chen X, Takai T*, Xie Y, François Niyonsaba. Okumura K. Ogawa H. Human antimicrobial peptide LL-37 modulates proinflammatory responses induced by cytokine milieus and double-stranded RNA in human keratinocytes. Biochem Biophys Res Commun 433:532-7 (2013) [査読有]
Nakazawa T*, Khan AF, Yasueda H, Saito A, Fukutomi Y, Takai T, Zaman K, Yunus M, Takeuchi H, Iwata T, Akiyama K. Immunization of rabbits with nematode Ascaris lumbricoides antigens induces antibodies cross-reactive to house dust mite Dermatophagoides farinae antigens. Biosc Biotechnol Biochem 77:145-150 (2013) [査読有]
Takai T*. Mite endopeptidase 1. In: Neil D. Rawlings and Guy S. Salvesen, editors, Handbook of Proteolytic Enzymes. Oxford: Academic Press/Elsevier, 2013, pp.1957-1963. [Book Chapter] [Review] [査読有]
Takai T*. Serine endopeptidase allergens from Dermatophagoides species. In: Neil D. Rawlings and Guy S. Salvesen, editors, Handbook of Proteolytic Enzymes. Oxford: Academic Press/Elsevier, 2013, pp.3055-3060. [Book Chapter] [Review] [査読有]
高井敏朗*. アレルゲンはなぜアレルゲンになるのか？: アレルゲンが引き起 こすバリア破壊と自然免疫応答. 実験医学 31: 2713-2719 (2013) [Review]
高井敏朗*. ダニアレルゲンによる経皮感作のメカニズム. アレルギー・免疫 20:854-860 (2013) [Review]
2012
Xie Y, Takai T*, Chen X, Okumura K, Ogawa H. Long TSLP transcript expression and release of TSLP induced by TLR ligands and cytokines in human keratinocytes. 66:233-237 (2012) [査読有]
Saeki M, Nishimura T, Kaminuma O, Suzuki K, Takai T, Mori A, Takada K, Takaiwa F, Hiroi T*. Inhibition of allergen-induced airway inflammation by low-dose oral immunotherapy with transgenic rice seeds independently of immunoglobulin E synthesis. Int Arch Allergy Immunol 158:66-69 (2012) [査読有]
Takai T*. TSLP expression: cellular sources, triggers, and regulatory mechanisms. Allergol Int 61:3-17 (2012) [Review][査読有]
高井敏朗*. アレルゲンの３つの顔. アレルギー 61:930-940 (2012) [Review]
高井敏朗*. 私は思う: アレルゲンとは何か．アレルギーの臨床 32:739-741 (2012) [Review]
高井敏朗*, 池田志斈. ダニアレルギーとアレルゲン．週刊日本医事新報 4582号57-59（2012）[Review]
高井敏朗*. Th2アジュバントとしての環境アレルゲンと黄色ブドウ菌：経皮的Th2感作におけるバリア破壊と自然免疫応答 日本皮膚アレルギー・接触皮膚炎学会雑誌 6:8-13 (2012) [Review][査読有]
高井敏朗*. アレルゲンの持つアジュバント作用と抗原感作機構．アレルギー・免疫 19:12-19 (2012）[Review]
2011
Vu AT, Chen X, Xie Y, Kamijo S, Ushio H, Kawasaki J, Hara M, Ikeda S, Okumura K, Ogawa H, Takai T*. Extracellular double-stranded RNA induces TSLP via an endosomal acidification- and NF-kB-dependent pathway in human keratinocytes. J Invest Dermatol 131:2205-2212 (2011) [査読有]
Le TA, Takai T*, Vu AT, Kinoshita H, Chen X, Ikeda S, Ogawa H, Okumura K. Flagellin induces the expression of thymic stromal lymphopoietin in human keratinocytes via Toll-like receptor 5. Int Arch Allergy Immunol 155:31-37 (2011) [査読有]
Suzuki K, Kaminuma O, Yang L, Takai T, Mori A, Umezu-Goto M, Ohtomo T, Ohmachi Y, Noda Y, Hirose S, Okumura K, Ogawa H, Takada K, Hirasawa M, Hiroi T, Takaiwa F*. Prevention of allergic asthma by vaccination with transgenic rice seed expressing mite allergen: induction of allergen-specific oral tolerance without bystander suppression. Plant Biotechnol J 9:982-990 (2011) [査読有]
Kawasaki J, Ushio H*, Kinoshita H, Fukai T, Niyonsaba F, Takai T, Ogawa H, Okumura K, Ikeda S. Viral infection induces Thymic stromal lymphopoietin (TSLP) in human keratinocyte. J Dermatol Sci 62:131-134 (2011) [査読有]
Takai T*, Ikeda S. Barrier dysfunction caused by environmental proteases in the pathogenesis of allergic diseases. Allergol Int 60:25-35 (2011) [Review][査読有]
Takai T*. Missions of protease allergens in the epithelium. Int Arch Allergy Immunol 154:3-5 (2011) [Editorial] [査読有]
高井敏朗*. アレルゲンはなぜアレルゲンになるのか．アレルギー 60:809-816 (2011) [査読有]
高井敏朗*. 表皮ケラチノサイトにおけるTSLP産生誘導．臨床免疫・アレルギー科 55:365-370 (2011) [査読有]
2010
Vu AT, Baba T, Chen X, Le TA, Kinoshita H, Xie Y, Kamijo S, Hiramatsu K, Ikeda S, Ogawa H, Okumura K, Takai T*. Staphylococcus aureus membrane and diacylated lipopeptide induce thymic stromal lymphopoietin in keratinocytes via the Toll-like receptor 2-Toll-like receptor 6 pathway. J Allergy Clin Immunol 126:985-993.e3 (2010) [査読有]
Hirasawa Y, Takai T*, Nakamura T, Mitsuishi K, Gunawan H, Suto H, Ogawa T, Wang XL, Ikeda S, Okumura K, Ogawa H. Staphylococcus aureus extracellular protease causes epidermal barrier dysfunction. J Invest Dermatol 130:614-617 (2010) [査読有]
Takai T*. Cedar allergen harvest from tobacco: Plant biotechnology for recombinant allergens. Int Arch Allergy Immunol 153:431-433 (2010) [Editorial] [査読有]
Le TA, Takai T*, Vu AT, Kinoshita H, Ikeda S, Ogawa H, Okumura K, Glucocorticoids inhibit double-stranded RNA-induced thymic stromal lymphopoietin release from keratinocytes in atopic cytokine milieu more effectively than tacrolimus. Int Arch Allergy Immunol 153:27-34 (2010) [査読有]
Vu AT, Takai T*, Le TA, Kinoshita H, Kamijo S, Hara M, Wang XL, Ogawa T, Ikeda S, Ogawa H, Okumura K. Proinflammatory response in human keratinocytes stimulated with ligands for TLR2, TLR1, and TLR6. Juntendo Medical Journal 56:50-55 (2010) [査読有]
高井敏朗*. ダニに由来するTh2アジュバント活性．臨床免疫・アレルギー科 54:619-624 (2010) [Review]
高井敏朗*, 上條清嗣：花粉のTh2アジュバント活性．臨床免疫・アレルギー科 54:625-630 (2010) [Review]
高井敏朗*. アレルゲンに対する自然免疫応答 呼吸 29:878-883 (2010) [Review]
高井敏朗*. 知っておかなければならないアレルギー疾患の基礎知識 (2) Th2アジュバントとしてのアレルゲン. アレルギー・免疫 17:687-694 (2010) [Review]
上條清嗣, 奥村康, 高井敏朗*. 樹状細胞の花粉成分によるTh2細胞誘導. 臨床免疫・アレルギー科 54: 313-322 (2010) [Review]
上條清嗣, 奥村康, 高井敏朗*. 花粉による樹状細胞の活性化．臨床免疫・アレルギー科 53: 312-320 (2010) [Review]
奥村康, 高井敏朗*. 環境因子とアレルギー疾患—特にアトピー性皮膚炎を中心にー．日中医学24: 47-52 (2010) [Review]
2009
Kinoshita H, Takai T*, Le TA, Kamijo S, Wang XL, Ushio H, Hara M, Vu AT, Kawasaki J, Ogawa T, Gunawan H, Ikeda S, Okumura K, Ogawa H. Cytokine milieu modulates release of thymic stromal lymphopoietin from human keratinocytes stimulated with double-stranded RNA. J Allergy Clin Immunol123:179-86 (2009) [査読有]
Takai T*, Kato T, Hatanaka H, Inui K, Nakazawa T, Ichikawa S, Mitsuishi K, Ogawa H, Okumura K. Modulation of allergenicity of major house dust mite allergens Der f 1 and Der p 1 by interaction with an endogenous ligand. J Immunol 183:7958-7965 (2009) [査読有]
Kamijo S, Takai T*, Kuhara T, Tokura T, Ushio H, Ota M, Harada N, Ogawa H, Okumura K. Cupressaceae pollen grains modulate dendritic cell response and exhibit IgE-inducing adjuvant activity in vivo. J Immunol 183: 6087-6094 (2009) [査読有]
Kato T, Takai T*, Fujimura T, Matsuoka H, Ogawa T, Murayama K, Ishii A, Ikeda S, Okumura K, Ogawa H. Mite serine protease activates protease-activated receptor-2 and induces cytokine release in human keratinocytes Allergy 64:1366-74 (2009) [査読有]
Le TA, Takai T*, Kinoshita H, Suto H, Ikeda S, Okumura K, Ogawa H. Inhibition of double-stranded RNA-induced TSLP in human keratinocytes by glucocorticoids. Allergy 64:1231-1232 (2009) [査読有]
Wang XL, Takai T*, Kamijo S, Gunawan H, Ogawa H, Okumura K. NADPH oxidase activity in allergenic pollen grains of different plant species. Biochem Biobhys Res Commun 387:430-434 (2009) [査読有]
Seto T, Takai T*, Ebihara N, Matsuoka H, Wang XL, Ishii A, Ogawa H, Murakami A, Okumura K. SLPI prevents cytokine release in mite protease-exposed conjunctival epithelial cells. Biochem Biobhys Res Commun 379:681-685 (2009) [査読有]
Takai T*, Ochiai Y, Ichikawa S, Sato E, Ogawa T, Tokura T, Kuhara T, Kawai H, Hatanaka H, Takakhashi S, Ogawa H, Okumura K. Enzyme-linked immunosorbent assays with high sensitivity for antigen-specific and total murine IgE: Useful tool for study of allergies in mouse models. Allergol Int 58:225-235 (2009) [査読有]
Ichikawa S, Takai T, Yashiki T, Takahashi S, Okumura K, Ogawa H, Kohda D, Hatanaka H*. Lipopolysaccharide binding of the mite allergen Der f 2. Genes Cells 14:1055-65 (2009) [査読有]
Suzuki K, Kaminuma O, Yang L, Motoi Y, Takai T, Ichikawa S, Okumura K, Ogawa H, Mori A, Takaiwa F, Hiroi T*. Development of transgenic rice expressing mite antigen for a new concept of immunotherapy. Int Arch Allergy Immunol 149 Suppl 1:21-24 (2009) [査読有]
Takai T*, Vu AT, Le TA, Kinoshita H, Ushio H, Ikeda S, Ogawa H, Okumura K. Reply. J Allergy Clin Immunol 124:864-5 (2009) [Correspondence]
高井敏朗*. アレルゲン研究の最前線 実験医学（増刊号：アレルギー疾患の免疫機構）．27:3340-3347 (2009) [Review]
高井敏朗*. ダニのアレルゲン活性とプロテアーゼ．臨床免疫アレルギー科 52:669-676. 2009 [Review]
高井敏朗*. アレルゲンに関する臨床・基礎の最近のトピックス．Minophagen Medical Review 54:71-83 (2009) [Review]
高井敏朗*. 抗原の成り立ち(5)新しい形のアレルゲンワクチン. Q&Aでわかるアレルギー疾患 5:338-342 (2009) [Review]
高井敏朗*. 抗原の成り立ち(4)アレルゲンはなぜアレルゲンになるのか？. Q&Aでわかるアレルギー疾患 5:218-221 (2009) [Review]
高井敏朗*. 抗原の成り立ち(3)アレルゲン分子のいろいろ. Q&Aでわかるアレルギー疾患 5:96-99 (2009) [Review]
2007-2008
Gunawan H, Takai T*, Ikeda S, Okumura K, Ogawa H. Protease activity of allergenic pollen of cedar, cypress, juniper, birch, and ragweed. Allergol Int 57:83-91 (2008) [査読有]
Gunawan H, Takai T*, Kamijo S, Wang XL, Ikeda S, Okumura K, Ogawa H. Characterization of proteases, proteins, and eicosanoid-like substances in soluble extracts from allergenic pollen grains Int Arch Allergy Immunol 147:276-288 (2008) [査読有]
Ogawa T, Takai T*, Kato T, Kikuchi T, Niyonsaba F, Ikeda S, Okumura K, Ogawa H. Upregulation of release of granulocyte-macrophage colony-stimulating factor from keratinocytes stimulated with cysteine protease activity of recombinant major mite allergens, Der f 1 and Der p 1. Int Arch Allergy Immunol 146:27-35 (2008) [査読有]
Kamijo S*, Nakajima A, Kamata K, Kurosawa H, Yagita H, Okumura K. Involvement of TWEAK/Fn14 interaction in the synovial inflammation of RA. Rheumatology (Oxford). 47:442-50 (2008) [査読有]
高井敏朗*. 抗原の成り立ち(2)アレルギー原因物質からアレルゲン分子へ. Q&Aでわかるアレルギー疾患 4: 602-605 (2008) [Review]
高井敏朗*. 抗原の成り立ち(1)アレルゲンに対する獲得免疫：IgE抗体とTh2応答. Q&Aでわかるアレルギー疾患 4: 526-529 (2008) [Review]
高井敏朗*. アレルゲンに含有されるプロテアーゼとアレルギー反応の誘導. 臨床免疫アレルギー科50:625-631 (2008) [Review]
高井敏朗*. 組換体アレルゲンワクチン. アレルギーの臨床 28:865-870 (2008) [Review]
高井敏朗*. ダニ主要アレルゲンの構造・機能と疾患誘導の関連性の解析およびワクチン設計：リコンビナントアレルゲンの応用．[第１７回アボットジャパン・アレルギー学術奨励賞] アレルギア 第36号, 60-64 (2007) [Review]
2006
Nakamura T, Hirasawa Y, Takai T*, Mitsuishi K, Okuda M, Kato T, Okumura K, Ikeda S, Ogawa H. Reduction of skin barrier function by proteolytic activity of a recombinant house dust mite allergen Der f 1. J Invest Dermatol 126:2719-2723(2006) [査読有]
Kikuchi Y, Takai T*, Kuhara T, Ota M, Kato T, Hatanaka H, Ichikawa S, Tokura T, Akiba H, Mitsuishi K, Ikeda S, Okumura K, Ogawa H. Crucial commitment of proteolytic activity of a purified recombinant major house dust mite allergen Der p 1 to sensitization towards IgE and IgG responses. J Immunol 177:1609-1617 (2006) [査読有]
Kikuchi Y, Takai T*, Ota M, Kato T, Takeda K, Mitsuishi K, Ikeda S, Okumura K, Ogawa H. Application of immunoreaction enhancer solutions to an enzyme-linked immunosorbent assay for antigen-specific IgE in mice immunized with recombinant major mite allergens or ovalbumin. Int Arch Allergy Immunol 141:322-330 (2006) [査読有]
Takai T*, Mizuuchi E, Kikuchi Y, Nagamune T, Okumura K, Ogawa H. Glycosylation of recombinant proforms of major house dust mite allergens Der p 1 and Der f 1 decelerates the speed of maturation Int Arch Allergy Immunol 139:181-187 (2006) [査読有]
Kamijo S*, Nakajima A, Ikeda K, Aoki K, Ohya K, Akiba H, Yagita H, Okumura K. Amelioration of bone loss in collagen-induced arthritis by neutralizing anti-RANKL monoclonal antibody. Biochem Biophys Res Commun. 347:124-32 (2006) [査読有]
Kamata K, Kamijo S, Nakajima A, Koyanagi A, Kurosawa H, Yagita H*, Okumura K. Involvement of TNF-like weak inducer of apoptosis in the pathogenesis of collagen-induced arthritis. J Immunol. 177:6433-9 (2006) [査読有]
高井敏朗*. プロテアーゼとしてのダニ抗原の意義．先端医療シリーズ３８皮膚疾患の最新医療（斎田俊明、飯塚一編）、先端医療技術研究所, 東京, p90-94 (2006)[Book Chapter] [Review]
高井敏朗*. ダニアレルゲン研究の現状. 臨床免疫・アレルギー科 46: 619-625 (2006) [Review]
高井敏朗*. ダニグループ１アレルゲン組換体の作製とその活性．アレルギー・免疫 19: 332-339 (2006) [Review]
2005
Kato T, Takai T*, Mitsuishi K, Okumura K, Ogawa H. Cystatin A inhibits IL-8 production by keratinocytes stimulated with Der p 1 and Der f 1: Biochemical skin-barrier against mite cysteine proteases. J Allergy Clin Immunol, 116:169-76 (2005) [査読有]
Takai T*, Kato T, Yasueda H, Okumura K, Ogawa H. Analysis of the structure and allergenicity of recombinant pro- and mature Der p 1 and Der f 1: Major conformational IgE-epitopes blocked by prodomains. J Allergy Clin Immunol 115:555-563 (2005) [査読有]
Takai T*, Kato T, Sakata Y, Yasueda H, Izuhara K, Okumura K, Ogawa H. Recombinant Der p 1 and Der f 1 exhibit cysteine protease activity but no serine protease activity. Biochem Biophys Res Commun 328:944-52 (2005) [査読有]
Nakazawa T, Takai T*, Hatanaka H, Mizuuchi E, Nagamune T, Okumura K, Ogawa H. Multiple-mutation at a potential ligand-binding region decreased allergenicity of a mite allergen Der f 2 without disrupting global structure. FEBS Lett 579:1988-1994 (2005) [査読有]
Takai T*, Kato T, Ota M, Yasueda H, Kuhara T, Okumura K, Ogawa H. Recombinant Der p 1 and Der f 1 with in vitro enzymatic activity to cleave human CD23, CD25, and alpha1-antitrypsin, and in vivo IgE-eliciting activity in mice. Int Arch Allergy Immunol, 137:194-200 (2005) [査読有]
Takai T*, Takaoka M, Yasueda H, Okumura K, Ogawa H. Dilution-method to refold bacterially expressed recombinant Der f 2 and Der p 2 to exhibit the secondary structure and histamine-releasing activity of natural allergens. Int Arch Allergy Immunol 137:1-8 (2005) [査読有]
Ichikawa S, Takai T, Inoue T, Yuuki T, Okumura Y, Ogura K, Inagaki F, Hatanaka H*. NMR study on the major mite allergen Der f 2: Its refined tertiary structure, epitopes for monoclonal antibodies and characteristics shared by ML protein group members. J Biochem 137:255-263 (2005) [査読有]
高井敏朗*. IgE産生とイエチリダニ由来プロテアーゼ．臨床免疫 44:541-545 (2005) [Review]
高井敏朗*. ダニ主要アレルゲンの構造と機能．臨床検査 49:739-747 (2005) [Review]
2003-2004
Sakata Y, Arima K, Takai T, Sakurai W, Masumoto K, Yuyama N, Suminami Y, Kishi F, Yamashita T, Kato T, Ogawa H, Fujimoto K, Matsuo Y, Sugita Y, Izuhara K*. The squamous cell carcinoma antigen 2 inhibits the cysteine proteinase activity of a major mite allergen, Der p 1. J Biol Chem. 279:5081-7 (2004) [査読有]
Sakata Y, Arima K, Takeshita K, Takai T, Aoki S, Ogawa H, Sugihara H, Fujimoto K, Izuhara K*. Characterization of novel squamous cell carcinoma antigen-related molecules in mice. Biochem Biophys Res Commun 324:1340-1345 (2004) [査読有]
Roeber D, Achari A, Takai T, Okumura Y, Scott DL*. Crystallization and preliminary X-ray analysis of Der f 2, a potent allergen derived from the house dust mite (Dermatophagoides farinae). Acta Cryst D59:1046-1048 (2003) [査読有]
高井敏朗*. アレルゲンの構造と機能: アレルギー発症との関連と、治療への新しいアプローチ. 喘息 17: 15-20 (2004) [査読有]
2002
Takai T*, Mineki R, Nakazawa T, Takaoka M, Yasueda H, Murayama K, Okumura K, Ogawa H: Maturation of recombinant mite allergen Der p 1 and Der f 1, and its implication in the blockade of proteplytic activity. FEBS Lett 531:265-272 (2002) [査読有]
高井敏朗*. アレルゲンエンジニアリング —アレルゲンの構造・機能とアレルギー・ネットワークの理解を基盤とした次世代の治療戦略—. 臨床免疫 38:298-305 (2002) [Review]
高井敏朗*. ダニ抗原のエンジニアリング—. アレルギー科 14:285-291 [Review]
羅智靖*, 高橋恭子, 西山千春, 高井敏朗, 柳原行義. 高親和性IgEレセプター(FcεRI)を標的としたマスト細胞活性化制御の展望 アレルギー科14,73-82 (2002) [Review]
2001
Yasuhara T, Takai T*, Yuuki T, Okudaira H, Okumura Y. Biologically active recombinant forms of a major house dust mite group 1 allergen Der f 1 with full activities of both cysteine protease and IgE binding. Clin Exp Allergy 31:116-124 (2001) [査読有]
Takahashi K, Takai T*, Yasuhara T, Yokota T, Okumura Y. Effects of site-directed mutagenesis in the cysteine residues and the N-glycosylation motif in recombinant Der f 1 on secretion and protease activity. Int Arch Allergy Immunol 124:454-460 (2001) [査読有]
Takai T*, Okumura K, Ra C, Yokota T, Okumura Y. Expression of humanized Fab fragments that recognize the IgE-binding domain of human FcεRIα chain. J Biochem 129:5-12 (2001) [査読有]
Takai T*, Takahashi K, Akagawa-Chihara M, Fukada M, Yuuki T, Shibuya I, Okumura K, Ra C, Yokota T, Okumura Y. Production of humanized antibody against human high-affinity IgE receptor in a serum free culture of CHO cells and purification of the Fab fragments. Biosc Biotechnol Biochem 65:1082-1089 (2001) [査読有]
Takai T*, Okumura K, Ra C. Direct expression of the extracellular portion of human FcεRIα chain in Escherichia coli. Biosc Biotechnol Biochem 65:79-85 (2001) [査読有]
Takai T*, Hatanaka H, Ichikawa S, Yokota T, Inagaki F, Okumura Y. Effects of double-mutation at two distant IgE-binding sites in the three dimensional structure of the major house dust mite allergen Der f 2 on IgE-binding and histamine releasing activity. Biosc Biotechnol Biochem 65:1601-1609 (2001) [査読有]
Takai T*, Akagawa-Chihara M, Yokota T, Okumura Y. 2001. Reactivities of mutants of a major house dust mite allergen Der f 2 to mouse anti-Der f 2 monoclonal antibodies analyzed by immunoblotting. Biosc Biotechnol Biochem 65:694-697 (2001) [査読有]
Yasuhara T, Takai T, Yuuki T, Okudaira H, Okumura Y. 2001. Cloning and expression of cDNA encoding the complete prepro-form of an isoform of Der f 1, the major group 1 allergen from house dust mite Dermatophagoides farinae. Biosc Biotechnol Biochem 65:563-569 (2001) [査読有]
2000
Takai T*, Ichikawa S, Yokota T, Hatanaka H, Inagaki F, Okumura Y. Unlocking the allergenic structure of the major house dust mite allergen Der f 2 by elimination of key intramolecular interactions. FEBS Lett 482:102-107 (2000) [査読有]
Takai T*, Ichikawa S, Hatanaka H, Inagaki F, Okumura Y. Effects of proline mutations in the major house dust mite allergen Der f 2 on IgE-binding and histamine-releasing activity. Eur J Biochem 267:6650-6656 (2000) [査読有]
Takai T, Yuuki T, Ra C*. Inhibition of IgE-dependent histamine release from human peripheral blood basophils by humanized Fab fragments that recognize the membrane proximal domain of the human FcεRI α chain. Int Arch Allergy Immunol 123:308-318 (2000) [査読有]
Takahashi K, Takai T, Yasuhara T, Yuuki T, Ohtake Y*, Yokota T, Okumura Y. Production of enzymatically and immunologically active Der f 1 in Escherichia coli. Int Arch Allergy Immunol 122:108-114 (2000) [査読有]
Takai T*, Yuuki T, Iwamoto-Yasue N, Okumura K, Ra C. Epitope analysis and primary structures of variable regions of anti-human FcεRI monoclonal antibodies, and expression of the chimeric antibodies fused with human constant regions. Biosc Biotechnol Biochem 64:1856-1867 (2000) [査読有]
Takahashi K*, Yuuki T, Takai T, Ra C, Yokota T, Okumura Y. Production of humanized Fab fragment against human high affinity IgE receptor in Pichia pastoris. Biosc Biotechnol Biochem 64:2138-2144 (2000) [査読有]
高井敏朗*. 減感作療法への応用を目的とした“アレルゲン・エンジニアリング”—遺伝子工学的に改変したダニ主要アレルゲンDer f 2におけるIgEエピトープの破壊とT細胞エピトープの温存—．アレルギー科10:173-178 (2000) [Review]
高井敏朗*. アレルゲンエンジニアリング”—ダニ主要アレルゲンDer f 2の改変—．医学のあゆみ192:983-988 (2000) [Review]
1998-1999
Takai T*, Mori A, Yuuki T, Okudaira H, Okumura Y. Non-anaphylactic combination of partially deleted fragments of the major house dust mite allergen Der f 2 for allergen-specific immunotherapy. Mol Immunol 36:1055-1065 (1999) [査読有]
Yasue M*, Yokota T, Fukada M, Takai T, Suko M, Okudaira H, Okumura Y. 1998. Hyposensitization to allergic reaction in rDer f 2-sensitized mice by the intranasal administration of a mutant of rDer f 2, C8/119S. Clin Exp Immunol 113:1-9 (1998) [査読有]
高井敏朗*, 羅智靖. 抗IgE, 抗IgE受容体療法．現代医療 30:847-852 (1998) [Review]
安江正明*, 高井敏朗, 中村伸, 羅智靖．ヒト型抗FcεRI抗体によるアレルギーの制御．アレルギー科6:388-394 (1998) [Review]
1997
Takai T*, Yokota T, Yasue M, Nishiyama C, Yuuki T, Mori A, Okudaira H, Okumura Y. Engineering of the major house dust mite allergen Der f 2 for allergen-specific immunotherapy. Nature Biotechnol 15:754-758 (1997) [査読有]
Takai T*, Yuuki T, Okumura Y, Mori A, Okudaira H. Determination of the N- and C-terminal sequences required to bind human IgE of the major house dust mite allergen Der f 2 and epitope mapping for monoclonal antibodies. Mol Immunol 34:255-261 (1997) [査読有]
Takai T*, Yuuki T, Okumura K, Ra C. 1997. An approach to control allergic reaction by blocking the binding of IgE to the high-affinity IgE receptor (FcεRI): Fab fragments of humanized anti-human FcεRIα antibody prevent degranulation of human basophils. Jpn J Inflamm 17:557-562. [Review] [査読有]
羅智靖*, 高井敏朗．1997. IgE-FcεRI-マスト細胞枢軸を標的にしたアレルギーの新しい治療戦略．モレキュラーメディシン34:1534-1541 (1997) [Review]
高井敏朗*, 羅智靖．ヒト型化抗体．アレルギー科4:478-484 (1997) [Review]
1991-1995
Nishiyama C*, Yuuki T, Takai T, Okumura Y, Okudaira H. Determination of three disulfide bonds in a major house dust mite allergen, Der f II. Int Arch Allergy Immunol 101:159-166 (1993) [査読有]
Nakano H*, Takai T, Kawakami Y, Nishimura H, Iwakura M. Secretion of a cytoplasmic protein using Escherichia coli α-hemolysin membrane transport system. Kagaku Kogaku Ronbunshu 17:687-693 (1991) [査読有]
高井敏朗*; 羅智靖．IgE結合阻害薬. 内科 76:760-766 (1995) [Review]
高井敏朗*, 羅智靖．高親和性IgE受容体. 小児科臨床 57(Suppl):27-32 (1994) [Review]
奥平博一*, 須甲松伸, 結城敏文, 高井敏朗, 岩本奈美子, 奥村康, 安藤徹, 猪好孝, 山川洋志, 岩城正廣. ダニアレルゲンの分子遺伝学的解析. Medical Immunology 23:125-133 (1992) [Review]