業績

  • 2014年

    1. Okazaki H, Lin Q, Nishikawa K, Ohtsuji N, Tsurui H, Ohtsuji M, Amano H, Tada N, Sudo K, Nishimura H, Shirai T, Hirose S. TNFa but not IL-17 is critical in the pathogenesis of rheumatoid arthritis spontaneously occurring in a unique-FcgRIIB-deficient mouse model. Mod Rheumatol. 2014 Nov; 24(6): 931-938.

    2. Oliva Trejo JA, Asanuma K, Kim E-H, Takagi-Akiba M, Nonaka K, Hidaka T, Komatsu M, Tada N, Ueno T. Transient increase in proteinuria, poly-ubiquitylated proteins and ER stress markers in podocyte-specific autophagy-deficient mice following unilateral nephrectomy. Biochem Biophys Res Commun. 2014 Apr; 446(4): 1190-1196.

    3. Furuya N, Ikeda SI, Sato S, Soma S, Ezaki J, Trejo JA, Takeda-Ezaki M, Fujimura T, Arikawa-Hirasawa E, Tada N, Komatsu M, Tanaka K, Kominami E, Hattori N, Ueno T. PARK2/Parkin-mediated mitochondrial clearance contributes to proteasome activation during slow-twitch muscle atrophy via NFE2L1 nuclear translocation. Autophagy. 2014 Apr; 10(4): 631-641.

    4. Nakajima M, Sugano H, Iimura Y, Higo T, Nakanishi H, Shimoji K, Karagiozov K, Miyajima M, Arai H: Sturge-Weber syndrome with spontaneous intracerebral hemorrhage in childhood. J Neurosurg Pediatr. 2014 Jan;13(1):90-3.

    5. Kamiya K, Hori M, Miyajima M, Nakajima M, Suzuki Y, Kamagata K, Suzuki M, Arai H, Ohtomo K, Aoki S: Axon diameter and intra-axonal volume fraction of the corticospinal tract in idiopathic normal pressure hydrocephalus measured by q-space imaging. PLoS One. 2014 Aug 5;9(8):e103842.

    6. Tsutsumi S, Ogino I, Miyajima M, Nakamura M, Yasumoto Y, Arai H, Ito M: Cranial Arachnoid Protrusions and Contiguous Diploic Veins in CSF Drainage. AJNR Am J Neuroradiol. 2014 Sep;35(9):1735-9.

    7. Nakajima M, Miyajima M, Ogino I, Sugano H, Akiba C, Domon N, Karagiozov KL, Arai H: Use of External Lumbar Cerebrospinal Fluid Drainage and Lumboperitoneal Shunts with Strata NSC Valves in Idiopathic Normal Pressure Hydrocephalus: A Single-Center Experience. World Neurosurg. 2014 Aug 6. pii: S1878-8750(14)00707-4.

    8. Okumura A, Yamamoto T, Miyajima M, Shimojima K, Kondo S, Abe S, Ikeno M, Shimizu T: 3p Interstitial Deletion Including PRICKLE2 in Identical Twins With Autistic Features. Pediatr Neurol 51(5): 730-733, 2014

    9. Nakashima M, Miyajima M, Sugano H, Iimura Y, Kato M, Tsurusaki Y, Miyake N, Saitsu H, Arai H, Matsumoto N: The somatic GNAQ mutation c.548G>A (p.R183Q) is consistently found in Sturge-Weber syndrome. Journal of Human Genetics 59(2):691-693, 2014

    10. Shimoji T, Tominaga D, Shimoji K, Miyajima M: Analysis of pre and post-operative symptoms of patients with mild trigonocephaly using several developmental and psychology tests. Childs Nerv Syst 2014 Dec 3[Epub ahead of print]

    11. Shibata N, Nagata T, Tagai K, Shinagawa S, Ohnuma T, Kawai E, Kasanuki K, Shimazaki H, Toda A, Tagata Y, Nakada T, Nakayama K, Yamada H, Arai H.　Association between the catechol-O-methyltransferase polymorphism Val158Met and Alzheimer’s disease in a Japanese population.　 Int J Geriatr Psychiatry.2014:Dec　9. doi:10.1002/gps.4237.

    12. Okazaki H, Lin Q, Nishikawa K, Ohtsuji N, Tsurui H, Ohtsuji M, Amano H, Tada N, Sudo K, Nishimura H, Shirai T, Hirose S. TNFa but not IL-17 is critical in the pathogenesis of rheumatoid arthritis spontaneously occurring in a unique-FcgRIIB-deficient mouse model. Mod Rheumatol. 2014 Nov; 24(6): 931-938.

    13. Oliva Trejo JA, Asanuma K, Kim E-H, Takagi-Akiba M, Nonaka K, Hidaka T, Komatsu M, Tada N, Ueno T. Transient increase in proteinuria, poly-ubiquitylated proteins and ER stress markers in podocyte-specific autophagy-deficient mice following unilateral nephrectomy. Biochem Biophys Res Commun. 2014 Apr; 446(4): 1190-1196.

    14. Furuya N, Ikeda SI, Sato S, Soma S, Ezaki J, Trejo JA, Takeda-Ezaki M, Fujimura T, Arikawa-Hirasawa E, Tada N, Komatsu M, Tanaka K, Kominami E, Hattori N, Ueno T. PARK2/Parkin-mediated mitochondrial clearance contributes to proteasome activation during slow-twitch muscle atrophy via NFE2L1 nuclear translocation. Autophagy. 2014 Apr; 10(4): 631-641.

    15． Katsura M, Hirose S, Sasaki H, Mori H, Kunimatsu A, Ohtomo K, Jimura K. Konishi S. Decreased fronto-temporal interaction during fixation after memory retrieval. PLoS ONE, 9, e110798, 2014

    16． Jimura K*, Hirose S*, Kunimatsu A, Ohtomo K, Koike Y, Konishi S. Late development of brain-behavior correlations during response inhibition. Neuroscience, 274, 383-392, 2014

    17． Watanabe T, Kan S, Koike T, Misaki M, Konishi S, Miyauchi S, Miyashita Y, Masuda N. Network-dependent modulation of brain activity during sleep. Neuroimage, 98, 1-10, 2014

    18．Hirose S, Jimura K, Kunimatsu A, Abe O, Ohtomo K, Miyashita Y, Konishi S. Changes in cerebro-cerebellar interaction during response inhibition after performance improvement. Neuroimage, 99, 142-148, 2014

    19． Watanabe T, Hanajima R, Shirota Y, Ohminami S, Tsutsumi R, Terao Y, Ugawa Y, Hirose S, Miyashita Y, Konishi S, Kunimatsu A, Ohtomo K. Bidirectional effects on inter-hemispheric resting-state functional connectivity induced by excitatory and inhibitory repetitive transcranial magnetic stimulation.Human Brain Mapping, 35, 1896-1905, 2014

    20． Watanabe T, Hirose S, Wada H, Imai Y, Machida T, Shirouzu I, Konishi S, Miyashita Y, Masuda N. Energy landscapes of resting-state brain networks. Frontiers in Neuroinformatics, 8, 12, 2014

    21． Kumano H, Uka T. Visual impairment by surrounding noise is due to interactions among stimuli in the higher-order visual cortex. J Neurophysiol 112: 620-630, 2014

    22． Hongo H, Tanaka Y, Shimada Y, Tanaka R, Hattori N, Urabe T. Dermatomal sensory manifestations in lateral medullary infarction. J Stroke Cerebrovasc Dis. 2014 Jan;23(1):182-3.

    23． Shen Q, Yamano K, Head BP, Kawajiri S, Cheung JT, Wang C, Cho JH, Hattori N, Youle RJ,　van der Bliek AM. Mutations in Fis1 disrupt orderly disposal of defective mitochondria. Mol Biol Cell. 2014 Jan;25(1):145-59.

    24． Shimo Y, Natori S, Oyama G, Nakajima M, Ishii H, Arai H, Hattori N. Subthalamic deep brain stimulation for a Parkinson’s disease patient with duplication of SNCA. Neuromodulation. 2014 Jan;17(1):102-3.

    25． Hattori N. Cerebral organoids model human brain development and microcephaly. Mov Disord. 2014 Feb;29(2):185.

    26． Mori A, Ueno Y, Kuroki T, Hoshino Y, Shimura H, Sekiguchi Y, Noguchi M, Hamada Y,　Kusunoki S, Hattori N, Urabe T. Motor-dominant polyneuropathy due to IgM monoclonal antibody against disialosyl gangliosides in a patient with mantle cell lymphoma. J Neurol Sci. 2014 Feb 15;337(1-2):215-8.

    27． Oyama G, Umemura A, Shimo Y, Nishikawa N, Nakajima A, Jo T, Nakajima M, Ishii H, Yamada D, Takanashi M, Arai H, Nanba E, Hattori N. Posterior Subthalamic Area Deep Brain Stimulation for Fragile X-Associated Tremor/Ataxia syndrome. Neuromodulation. 2014 Dec;17(8):721-3.

    28． Tomizawa Y, Tanaka R, Sekiguchi K, Oji Y, Tanaka Y, Yamashiro K, Hattori N. Cerebral infarction in a case of Parry-Romberg syndrome. J Stroke Cerebrovasc Dis. 2014 Feb;23(2):393-4.

    29． Ueno Y, Yamashiro K, Tanaka Y, Watanabe M, Shimada Y, Kuroki T, Miyamoto N, Daimon M, Tanaka R, Miyauchi K, Daida H, Hattori N, Urabe T. Rationale and design of the EPISTEME trial: efficacy of post-stroke intensive rosuvastatin treatment for aortogenic embolic stroke.Cardiovasc Drugs Ther. 2014 Feb;28(1):79-85.

    30． Yamanaka T, Tosaki A, Kurosawa M, Matsumoto G, Koike M, Uchiyama Y, Maity SN, Shimogori T, Hattori N, Nukina N. NF-Y inactivation causes atypical neurodegeneration characterized by ubiquitin and p62 accumulation and endoplasmic reticulum disorganization. Nat Commun. 2014 Feb 25;5:3354.

    31． Fukae J, Ishikawa K, Hatano T, Yoritaka A, Takanashi M, Shimo Y, Tsugawa J, Tsuboi Y, Hattori N. Serum uric acid concentration is linked to wearing-off fluctuation in Japanese Parkinson’s disease patients. J Parkinsons Dis. 2014;4(3):499-505.

    32． Hatano T, Hattori N, Kawanabe T, Terayama Y, Suzuki N, Iwasaki Y, Fujioka T; Yokukansan Parkinson’s Disease Study Group. An exploratory study of the efficacy and safety of yokukansan for neuropsychiatric symptoms in patients with Parkinson’s disease. J Neural Transm. 2014;121(3):275-81.

    33． Kamagata K, Tomiyama H, Hatano T, Motoi Y, Abe O, Shimoji K, Kamiya K, Suzuki M, Hori M, Yoshida M, Hattori N, Aoki S. A preliminary diffusional kurtosis imaging study of Parkinson disease: comparison with conventional diffusion tensor imaging. Neuroradiology. 2014 Mar;56(3):251-8.

    34． Kerever A, Mercier F, Nonaka R, de Vega S, Oda Y, Zalc B, Okada Y, Hattori N, Yamada Y, Arikawa-Hirasawa E. Perlecan is required for FGF-2 signaling in the neural stem cell niche. Stem Cell Res. 2014 Mar;12(2):492-505.

    35． Funabe S, Tanaka R, Hayashi A, Yamashiro K, Shimura H, Hattori N. Reversible dropped head syndrome after hemispheric striatal infarction. J Stroke Cerebrovasc Dis. 2014 Apr;23(4):785-7.

    36． Furuya N, Ikeda S, Sato S, Soma S, Ezaki J, Oliva Trejo JA, Takeda-Ezaki M, Fujimura T, Arikawa-Hirasawa E, Tada N, Komatsu M, Tanaka K, Kominami E, Hattori N, Ueno T. PARK2/Parkin-mediated mitochondrial clearance contributes to proteasome activation during slow-twitch muscle atrophy via NFE2L1 nuclear translocation. Autophagy. 2014 Apr;10(4):631-41.

    37． Ishikawa K, Saiki S, Furuya N, Yamada D, Imamichi Y, Li Y, Kawajiri S, Sasaki H, Koike M, Tsuboi Y, Hattori N. P150glued-associated disorders are caused by activation of intrinsic apoptotic pathway. PLoS One. 2014 Apr 10;9(4):e94645.

    38． Li Y, Sekine T, Funayama M, Li L, Yoshino H, Nishioka K, Tomiyama H, Hattori N. Clinicogenetic study of GBA mutations in patients with familial Parkinson’s disease. Neurobiol Aging. 2014 Apr;35(4):935.e3-8.

    39． Motoi Y, Shimada K, Ishiguro K, Hattori N. Lithium and autophagy. ACS Chem Neurosci. 2014 Jun 18;5(6):434-42.

    40． Noda K, Hattori N, Okuma Y. Primary central nervous system lymphoma presenting as choreoathetosis. BMJ Case Rep. 2014 Apr 16;2014. pii: bcr2013203353.

    41． Okuzumi A, Hatano T, Nakahara T, Yokoyama K, Hattori N. Ophthalmic nerve hypertrophy in chronic inflammatory demyelinating polyradiculoneuropathy. Neurology. 2014 Apr 29;82(17):1566-7.

    42． Yamanaka T, Wong HK, Tosaki A, Bauer PO, Wada K, Kurosawa M, Shimogori T, Hattori N, Nukina N. Large-scale RNA interference screening in mammalian cells identifies novel regulators of mutant huntingtin aggregation. PLoS One. 2014 Apr 4;9(4):e93891.

    43． Yamashiro K, Tanaka R, Tanaka Y, Miyamoto N, Shimada Y, Ueno Y, Urabe T, Hattori N. Visceral fat accumulation is associated with cerebral small vessel disease. Eur J Neurol. 2014 Apr;21(4):667-73.

    44． Fujimaki T, Saiki S, Tashiro E, Yamada D, Kitagawa M, Hattori N, Imoto M. Identification of licopyranocoumarin and glycyrurol from herbal medicines as neuroprotective compounds for Parkinson’s disease. PLoS One. 2014 Jun 24;9(6):e100395.

    45． Ishikawa K, Motoi Y, Mizuno Y, Kubo S, Hattori N. Effects of donepezil dose escalation in Parkinson’s patients with dementia receiving long-term donepezil treatment: an exploratory study. Psychogeriatrics. 2014 Jun;14(2):93-100.

    46． Nishioka K, Funayama M, Vilariño-Güell C, Ogaki K, Li Y, Sasaki R, Kokubo Y, Kuzuhara S, Kachergus JM, Cobb SA, Takahashi H, Mizuno Y, Farrer MJ, Ross OA, Hattori N. EIF4G1 gene mutations are not a common cause of Parkinson’s disease in the Japanese population. Parkinsonism Relat Disord. 2014 Jun;20(6):659-61.

    47． Shiba-Fukushima K, Inoshita T, Hattori N, Imai Y. PINK1-mediated phosphorylation of Parkin boosts Parkin activity in Drosophila. PLoS Genet. 2014 Jun 5;10(6):e1004391.

    48． Hori M, Yoshida M, Yokoyama K, Kamagata K, Kumagai F, Fukunaga I, Kamiya K, Suzuki M, Masutani Y, Hamasaki N, Suzuki Y, Kyogoku S, Hattori N, Aoki S. Multiple sclerosis: Benefits of q-space imaging in evaluation of normal-appearing and periplaque white matter. Magn Reson Imaging. 2014 Jul;32(6):625-9.

    49．Yamashita C, Tomiyama H, Funayama M, Inamizu S, Ando M, Li Y, Yoshino H, Araki T, Ichikawa T, Ehara Y, Ishikawa K, Mizusawa H, Hattori N. Evaluation of polyglutamine repeats in autosomal dominant Parkinson’s disease. Neurobiol Aging. 2014 Jul;35(7):1779.e17-21.

    50．Hattori N, Nomoto M; 6500-004 Study Group. Sustained efficacy of apomorphine in Japanese patients with advanced Parkinson’s disease. Parkinsonism Relat Disord. 2014 Aug;20(8):819-23.

    51． Hattori N, Saiki S, Imai Y. Regulation by mitophagy. Int J Biochem Cell Biol.2014 Aug;53:147-50.

    52． Nishioka K, Tanaka R, Tsutsumi S, Yamashiro K, Nakahara M, Shimura H, Hattori N, Urabe T. Cerebral dural sinus thrombosis associated with adenomyosis: a case report. J Stroke Cerebrovasc Dis. 2014 Aug;23(7):1985-7.

    53． Amo T, Saiki S, Sawayama T, Sato S, Hattori N. Detailed analysis of mitochondrial respiratory chain defects caused by loss of PINK1. Neurosci Lett.2014 Sep 19;580:37-40.

    54． Maraschi A, Ciammola A, Folci A, Sassone F, Ronzitti G, Cappelletti G, Silani V, Sato S, Hattori N, Mazzanti M, Chieregatti E, Mulle C, Passafaro M, Sassone J. Parkin regulates kainate receptors by interacting with the GluK2 subunit. Nat Commun. 2014 Oct 15;5:5182.

    55． Mitome-Mishima Y, Miyamoto N, Tanaka R, Shimosawa T, Oishi H, Arai H, Hattori N, Urabe T. Adrenomedullin deficiency and aging exacerbate ischemic white matter injury after prolonged cerebral hypoperfusion in mice. Biomed Res Int. 2014;2014:861632.

    56． Mizuno Y, Nomoto M, Hasegawa K, Hattori N, Kondo T, Murata M, Takeuchi M, Takahashi M, Tomida T; on behalf of the Rotigotine Trial Group. Rotigotine vs ropinirole in advanced stage Parkinson’s disease: A double-blind study. Parkinsonism Relat Disord. 2014 Oct 12;20(12):1388-1393.

    57． Nakahara K, Ueda M, Yamada K, Koide T, Yoshimochi G, Funayama M, Kim JH, Yamakawa S, Mori A, Misumi Y, Uyama E, Hattori N, Ando Y. Juvenile-onset parkinsonism with digenic parkin and PINK1 mutations treated with subthalamic nucleus stimulation at 45 years after disease onset. J Neurol Sci. 2014 Oct 15;345(1-2):276-7.

    58. Shimada Y, Tanaka R, Shimura H, Yamashiro K, Urabe T, Hattori N. Phosphorylation enhances recombinant HSP27 neuroprotection against focal cerebral ischemia in mice. Neuroscience. 2014 Oct 10;278:113-21.

    59． Ueno Y, Okuzumi A, Watanabe M, Tanaka Y, Shimada Y, Yamashiro K, Tanaka R, Hattori N, Urabe T. Cerebral small artery diseases may be associated with aortic arch calcification in stroke patients. J Atheroscler Thromb. 2014;21(10):1011-21.

    60． Hatano T, Funayama M, Kubo S, Mata IF, Oji Y, Mori A, Zabetian CP, Waldherr SM, Yoshino H, Oyama G, Shimo Y, Fujimoto K, Oshima H, Kunii Y, Yabe H, Mizuno Y, Hattori N. Identification of a Japanese family with LRRK2 p.R1441G-related Parkinson’s disease. Neurobiol Aging. 2014 Nov;35(11):2656.e17-23.

    61． Kurita N, Ueno Y, Watanabe M, Miyamoto N, Shimura H, Nonaka S, Tsutsumi S, Yasumoto Y, Hattori N, Urabe T. Three cases of cervicocephalic artery dissection in an amusement park. J Stroke Cerebrovasc Dis. 2014 Nov-Dec;23(10):e467-71.

    62． Kuroki T, Yamashiro K, Tanaka R, Hirano K, Shimada Y, Hattori N. Vertebral artery dissection in patients with autosomal dominant polycystic kidney disease. J Stroke Cerebrovasc Dis. 2014 Nov-Dec;23(10):e441-3.

    63． Miyazaki H, Oyama F, Inoue R, Aosaki T, Abe T, Kiyonari H, Kino Y, Kurosawa M, Shimizu J, Ogiwara I, Yamakawa K, Koshimizu Y, Fujiyama F, Kaneko T, Shimizu H, Nagatomo K, Yamada K, Shimogori T, Hattori N, Miura M, Nukina N. Singular localization of sodium channel β4 subunit in unmyelinated fibres and its role in the striatum. Nat Commun. 2014 Nov 21;5:5525.

    64． Nishioka K, Tanaka R, Shimura H, Hirano K, Hatano T, Miyakawa K, Arai H, Hattori N, Urabe T. Quantitative evaluation of electroconvulsive therapy for Parkinson’s disease with refractory psychiatric symptoms. J Neural Transm. 2014 Nov;121(11):1405-10.

    65． Shiba-Fukushima K, Inoshita T, Hattori N, Imai Y. Lysine 63-linked Polyubiquitination Is Dispensable for Parkin-mediated Mitophagy. J Biol Chem. 2014 Nov 28;289(48):33131-6.

    66 ．Shiba-Fukushima K, Arano T, Matsumoto G, Inoshita T, Yoshida S, Ishihama Y, Ryu KY, Nukina N, Hattori N, Imai Y. Phosphorylation of mitochondrial polyubiquitin by PINK1 promotes Parkin mitochondrial tethering. PLoS Genet.　2014, 10:e1004861.

    67． Kashihara K, Kondo T, Mizuno Y, Kikuchi S, Kuno S, Hasegawa K, Hattori N, Mochizuki H, Mori H, Murata M, Nomoto M, Takahashi R, Takeda A, Tsuboi Y, Ugawa Y, Yamanmoto M, Yokochi F, Yoshii F, Stebbins GT, Tilley BC, Luo S, Wang L, LaPelle NR, Goetz CG; MDS-UPDRS Japanese Validation Study Group. Official Japanese Version of the Movement Disorder Society-Unified Parkinson’s Disease Rating Scale: validation against the original English version. Mov Disord Clin Pract (Hoboken). 2014 Sep 1;1(3):200-212.

    68． Tanaka Y, Ueno Y, Shimada Y, Yamashiro K, Tanaka R, Urabe T, Hattori N. Paradoxical Brain Embolism Associated with Kimura Disease Mimics Watershed Infarction. J Stroke Cerebrovasc Dis. 2014 Nov 25. pii: S1052-3057(14)00479-0.

    69. Akamatsu H, Koh Y, Kenmotsu H, Naito T, Serizawa M, Kimura M, Mori K, Imai H, Ono A, Shukuya T, Taira T, Murakami H, Ohde Y, Endo M, Nakajima T, Takahashi T, Yamamoto N.Multiplexed molecular profiling of lung cancer using pleural effusion.J Thorac Oncol. 2014 Jul; 9(7): 1048-52.

    70. Akamatsu H, Mori K, Naito T, Imai H, Ono A, Shukuya T, Taira T, Kenmotsu H, Murakami H, Endo M, Harada H, Takahashi T, Yamamoto N.Progression-free survival at 2 years is a reliable surrogate marker for the 5-year survival rate in patients with locally advanced non-small cell lung cancer treated with chemoradiotherapy.BMC Cancer. 2014 Jan; 14: 18.

    71. Ando K, Takahashi F, Kato M, Kaneko N, Doi T, Ohe Y, Koizui F, Nishio K, Takahashi K.Tocilizumab, a proposed therapy for the cachexia of interleukin6-expressing lung cancer.PLoS One. 2014 Jul; 9(7): e102436.

    72. Ando K, Kaneko N, Doi T, Aoshima M, Takahashi K. Prevalence and risk factors of aortic aneurysm in patients with chronic obstructive pulmonary disease.J Thorac Dis. 2014 Oct; 6(10): 1388-95.

    73. Fujii M, Iwakami S, Itoigawa Y, Takahashi K.Interesting radiological images of a tuberculous abscess.Intern Med. 2014; 53(10): 1097-8.

    74. Haga T, Kataoka H, Ebana H, Otsuji M, Seyama K, Tatsumi K, Kurihara M.Thoracic endometriosis-related pneumothorax distinguished from primary spontaneous pneumothorax in females.Lung. 2014 Aug;192(4):583-7.

    75. Hasegawa S, Wakiguchi H, Okada S, Gui Kang Y, Fujii N, Hasegawa M, Hasegawa H, Ainai A, Atsuta R, Shirabe K, Toda S, Wakabayashi-Takahara M, Morishima T, Ichiyama T.Cytokine profile of bronchoalveolar lavage fluid from a mouse model of bronchial asthma during seasonal H1N1 infection.Cytokine. 2014 Oct; 69(2): 206-10.

    76. Ito R, Gon Y, Nunomura S, Atsuta R, Harada N, Hattori T, Maruoka S, Okayama Y, Ra C, Hashimoto S.Development of assay for determining free IgE levels in serum from patients treated with omalizumab.Allergol Int. 2014 May; 63 Suppl 1:37-47.

    77. Iwakami S, Ihara H, Fujii M, Takahashi K. A pulmonary nodule exhibiting temporary spontaneous regression. Intern Med. 2014; 53(4): 337-8

    78. Imai H, Takahashi T, Mori K, Ono A, Akamatsu H, Shukuya T, Taira T, Kenmotsu H, Naito T, Murakami H, Endo M, Nakajima T, Yamamoto N.Individual-level data on the relationships of progression-free survival, post-progression survival, and tumor response with overall survival in patients with advanced non-squamous non-small cell lung cancer.Neoplasma. 2014; 61(2): 233-40.

    79. Ishida K, Sekizuka T, Hayashida K, Matsuo J, Takeuchi F, Kuroda M, Nakamura S, Yamazaki T, Yoshida M, Takahashi K, Nagai H, Sugimoto C, Yamaguchi H. Amoebal endosymbiont Neochlamydia genome sequence illuminates the bacterial role in the defense of the host amoebae against Legionella pneumophila. PLoS One. 2014 Apr; 9(4): e95166.

    80. Kamachi F,　Harada N,　Usui Y,　Sakanishi T,　Ishii N,　Okumura K,　Miyake S,　Akiba H.OX40 ligand regulates splenic CD8-dendritic cell-induced Th2 responses in vivo.　Biochemical and Biophysical Research Communications. 2014; 444(2): 235-240.

    81. Kanaji N, Basma H, Nelson A, Farid M, Sato T, Nakanishi M, Wang X, Michalski J, Li Y, Gunji Y, Feghali-Bostwick C, Liu X, Rennard SI.Fibroblasts that resist cigarette smoke-induced senescence acquire profibrotic phenotypes.Am J Physiol Lung Cell Mol Physiol. 2014 Sep; 307(5): L364-73.

    82. Kato M, Shukuya T, Takahashi F, Mori K, Suina K, Asao T, Kanemaru R, Honma Y, Muraki K, Sugano K, Shibayama R, Koyama R, Shimada N, Takahashi K. Pemetrexed for advanced non-small cell lung cancer patients with interstitial lung disease.BMC Cancer. 2014 Jul; 14(1): 508.

    83. Ko R, Kenmotsu H, Hisamatsu Y, Akamatsu H, Omori S, Nakashima K, Oyakawa T, Wakuda K, Shukuya T, Ono A, Imai H, Taira T, Naito T, Murakami H, Mori K, Endo M, Ohde Y, Takahashi K, Takahashi T.The effect of gefitinib in patients with postoperative recurrent non-small cell lung cancer harboring mutations of the epidermal growth factor receptor.Int J Clin Oncol. 2014 Oct; 25.

    84. Koike K, Ishigami A, Sato Y, Hirai T, Yuan Y, Kobayashi E, Tobino K, Sato T, Sekiya M, Takahashi K, Fukuchi Y, Maruyama N, Seyama K.Vitamin C prevents cigarette smoke-induced pulmonary emphysema in mice and provides pulmonary restoration.Am J Respir Cell Mol Biol. 2014; 50(2): 347-57.

    85. Kumasaka T, Hayashi T, Mitani K, Kataoka H, Kikkawa M, Tobino K, Kobayashi E, Gunji Y, Kunogi M, Kurihara M, Seyama K.Characterization of pulmonary cysts in Birt-Hogg-Dubé syndrome: histopathological and morphometric analysis of 229 pulmonary cysts from 50 unrelated patients.Histopathology. 2014 Jul; 65(1): 100-10.

    86. Kuriyama S, Morio Y, Toba M, Nagaoka T, Takahashi F, Iwakami S, Seyama K, Takahashi K.Genistein attenuates hypoxic pulmonary hypertension via enhanced nitric oxide signaling and the erythropoietin system. Am J Physiol Lung Cell Mol Physiol. 2014 Jun; 306(11): L996-L1005.

    87. Li YJ, Kanaji N, Wang XQ, Sato T, Nakanishi M, Kim M, Michalski J, Nelson AJ, Farid M, Basma H, Patil A, Toews ML, Liu X, Rennard SI.Prostaglandin E2 switches from a stimulator to an inhibitor of cell migration after epithelial-to-mesenchymal transition.Prostaglandins Other Lipid Mediat. 2014 Oct; 31: 116-117, C:1-9.

    88. Mizugaki H, Fujiwara Y, Yamamoto N, Yagishita S, Kitazono S, Tanaka A, Horinouchi H, Kanda S, Nokihara H, Tsuta K, Asamura H, Tamura T.Adjuvant chemotherapy in patients with completely resected small cell lung cancer: a retrospective analysis of 26 consecutive cases.Jpn J Clin Oncol. 2014 Sep; 44(9): 835-40.

    89. Murakami A, Takahashi F, Nurwidya F, Kobayashi I, Minakata K, Hashimito M, Nara T, Kato M, Tajima K, Shimada N,Iwakami S, Moriyama M, Moriyama H, Koizumi F, Takahashi K. Hypoxia increases gefitinib-resistant lung cancer stem cells through the activation of insulin-like growth factor 1 receptor.PLoS One. 2014 Jan; 9(1): e86459.　

    90. Murakami A, Hayashi T, Terao Y, Mori T, Kumasaka T, Seyama K, Takahashi K.Cystic, nodular and cavitary metastases to the lungs in a patient with endometrial stromal sarcoma of the uterus.Intern Med. 2014; 53(9): 1001-5.

    91. Nakashita T, Ando K, Kaneko N, Takahashi K, Motojima S.Potential risk of TNF inhibitors on the progression of interstitial lung disease in patients with rheumatoid arthritis.BMJ Open. 2014; 4: e005615.

    92. Nakagawa N, Saito Y, Sasaki M, Tsuda Y, Mochizuki H, Takahashi H. Comparison of clinical profile in elderly patients with nursing and healthcare-associated pneumonia and those with community-acquired pneumonia.Geriatr Gerontol Int. 2014 Apr;14(2):362-71.

    93. Nurwidya F, Takahashi F, Kobayashi I, Murakami A, Kato M, Minakata K, Nara T, Hashimoto M, Yagishita Y, Baskoro H, Hidayat M, Shimada N, Takahashi K.Treatment with insulin-like growth factor 1 receptor inhibitor reverses hypoxia-induced epithelial-mesenchymal transition in non-small cell lung cancer Biochem Biophys Res Commun. 2014; 12: 455(3-4):332-8.

    94. Sato T, Suzuki Y, Mori T, Maeda M, Abe M, Hino O, Takahashi K.Newly established ELISA for N-ERC/mesothelin improves diagnostic accuracy in patients with suspected pleural mesothelioma.Cancer Med. 2014 Oct; 3(5):1377-84.

    95. Shiota S, Inoue Y, Takekawa H, Kotajima M, Nakajyo M, Usui C, Yoshioka Y, Koga T, Takahashi K.Effect of continuous positive airway pressure on regional cerebral blood flow during wakefulness in obstructive sleep apnea.Sleep Breath. 2014; 18(2): 289-95.

    96. Shukuya T, Serizawa M, Watanabe M, Akamatsu H, Abe M, Imai H, Tokito T, Ono A, Taira T, Kenmotsu H, Naito T, Murakami H, Takahashi T, Endo M, Ohde Y, Nakajima T, Yamamoto N, Koh Y.Identification of actionable mutations in malignant pleural mesothelioma.Lung Cancer. 2014 Oct; 86(1): 35-40.

    97. Shukuya T, Takahashi T, Imai H, Tokito T, Ono A, Akamatsu H, Taira T, Kenmotsu H, Naito T, Murakami H, Endo M, Yamamoto N.Comparison of cisplatin plus pemetrexed and cisplatin plus gemcitabine for the treatment of malignant pleural mesothelioma in Japanese patients.Respir Investig. 2014 Mar; 52(2): 101-6.

    98. Suina K, Hayashi T, Mitani K, Suzuki K, Takahashi K, Seyama K. What׳s the role of sirolimus on the treatment of lymphangioleiomyomatosis (LAM)?: Merely tuning up of LAM-associated dysfunctional lymphatic vessels rather than cytoreduction?Respir Investig. 2014 Jul; 52(4): 274-6.

    99. Tokito T, Shukuya T, Akamatsu H, Ono A, Taira T, Kenmotsu H, Naito T, Murakami H, Takahashi T, Endo M, Mori K, Yamamoto N.Toxicity and efficacy of chemotherapy for non-small cell lung cancer with cavitary lesions.Respir Investig. 2014 May; 52(3):184-9.

    100.Wang XQ, Mao LJ, Fang QH, Kobayashi T, Kim HJ, Sugiura H, Kawasaki S, Togo S, Kamio K, Liu X, Rennard SI.Sphingosylphosphorylcholine induces α-smooth muscle actin expression in human lung fibroblasts and fibroblast-mediated gel contraction via S1P2 receptor and Rho/Rho-kinase pathway.Prostaglandins Other Lipid Mediat. 2014 Jan; 108: 23-30.

    101. Yagishita S, Horinouchi H, Taniyama K, Nakamichi S, Kitazono S, Mizugaki H, Kanda S, Fujiwara Y, Nokihara H, Yamamoto N, Sumi M, Shiraishi K, Kohno T, Furuta K, Tsuta K, Tamura T.Epidermal Growth Factor Receptor Mutation Is Associated With Longer Local Control After Definitive Chemoradiotherapy in Patients With Stage III Nonsquamous Non-Small-Cell Lung Cancer.Int J Radiat Oncol Biol Phys. 2014 Oct; S0360-3016(14)04051-6.

    102.Yagishita S, Horinouchi H, Yorozu T, Kitazono S, Mizugaki H, Kanda S, Fujiwara Y, Nokihara H, Yamamoto N, Mori T, Tsuta K, Sumi M, Tamura T.Secondary osteosarcoma developing 10 years after chemoradiotherapy for non-small-cell lung cancer.Jpn J Clin Oncol. 2014 Feb; 44(2): 191-4.

    103.Suzuki N, Numakawa T Joshua Chou J, de Vega, S, Mizuniwa C, Sekimoto K, Adachi N, Kunugi N, Arikawa-Hirasawa E, Yamada Y, Akazawa C. Teneurin-4 promotes cellular protrusion formation and neurite outgrowth through focal adhesion kinase signaling . The FASEB Journal article fj.13-241034. Published online. 2014 28:1386-97.

    104. Kerever A Mercier F, Nonaka R, de Vega S, Oda Y, Zalc B, Okada Y, Hattori N, Yamada Y, Arikawa-Hirasawa, Perlecan is required for FGF-2 signaling in the neural stem cell niche. Stem Cell Res. 2014 12:492-505.

    105. Furuya N, Ikeda SI, Sato S, Soma S, Ezaki J, Trejo JA, Takeda-Ezaki M, Fujimura T, Arikawa-Hirasawa E, Tada N, Komatsu M, Tanaka K, Kominami E, Hattori N, Ueno T. PARK2/Parkin-mediated mitochondrial clearance contributes to proteasome activation during slow-twitch muscle atrophy via NFE2L1 nuclear translocation. Autophagy. 10:631-41. 2014 Jan 21.

    106. de Vega S, Suzuki N, Nonaka R, Sasaki T, Forcinito P, Arikawa-Hirasawa E, Yamada Y. A C-terminal fragment of fibulin-7 interacts with endothelial cells and inhibits their tube formation in culture. Arch Biochem Biophys. 1;545:148-53. 2014

    107. Ning L, Kurihara H, de Vega S,* Ichikawa-Tomikawa n, Xu Z,Nonaka R, Kazuno S, Yamada Y, Miner JH, Arikawa-HirasawA E, Laminin α1 regulates age-related mesangial cell proliferation and mesangial matrix accumulation through the TGFβ pathway The American Journal of Pathology . 184:1683-94.2014.

    108. Ito T, Sato K, Maekawa H, Sakurada M, Orita H, Shimada K, Daida H, Wada R, Abe M, Hino O, Kajiyama Y. Elevated levels of serum fatty acid synthase in patients with gastric carcinoma. Oncol Lett. 7:616-620;2014.

    109. Miyazaki T, Shimada K, Hki M, Kume A, Kitamura Y, Oshida K, Yanagisawa N, Kiyanagi T, Matsumori R, Daida H. High hexacosanoic acid levels are associated with coronary artery disease. Atherosclerosis. 223:429-433;2014.

    110. Nishizaki Y, Shimada K, Tani S, Ogawa T, Ando J, Takahashi M, Yamamoto M, Shinozaki T, Miyauchi K, Nagao K, Hirayama A, Yoshimura M, Komuro I, Nagai R, Daida H. Significance of Imbalance in the Ratio of Serum n-3 to n-6 Polyunsaturated Fatty Acids in Patients with Acute Coronary Syndrome, Am J Cardiol. 113:441-445;2014.

    111. Yokoi H, Nohara R, Daida H, Hata M, Kaku K, Kawamori R, Kishimoto J, Kurabayashi M, Masuda I, Sakuma I, Yamazaki T, Yoshida M. Change in carotid intima-media thickness in a high-risk group of patients by intensive lipid-lowering therapy with rosuvastatin. Int Heart J. 2014 Mar 28;55(2):146-52

    112. Teramoto T, Sasaki J, Ishibashi S, Birou S, Daida H, Dohi S, Egusa G, Hiro T, Hirobe K, Iida M, Kihara S, Kinoshita M, Maruyama C, Ohta T, Okamura T, Yamashita S, Yokode M, Yokote K. Familial hypercholesterolemia. J Atheroscler Thromb. 2014 Mar 27;21(3):289.

    113. Daida H, Teramoto T, Kitagawa Y, Matsushita Y, Sugihara M. The relationship between low-density lipoprotein cholesterol levels and the incidence of cardiovascular disease in high-risk patients treated with pravastatin: main results of the APPROACH-J study. Int Heart J. 2014;55(1):39-47.

    114. Ohmura T, Iwama Y, Kasai T, Kato T, Suda S, Takagi A, Daida H. Impact of predischarge nocturnal pulse oximetry (sleep-disordered breathing) on postdischarge clinical outcomes in hospitalized patients with left ventricular systolic dysfunction after acute decompensated heart failure. Am J Cardiol. 2014 Feb 15;113(4):697-700.

    115. Teramoto T, Sasaki J, Ishibashi S, Birou S, Daida H, Dohi S, Egusa G, Hiro T, Hirobe K, Iida M, Kihara S, Kinoshita M, Maruyama C, Ohta T, Okamura T, Yamashita S, Yokode M, Yokote K, Harada-Shiba M, Arai H, Bujo H, Nohara A, Ohta T, Oikawa S, Okada T, Wakatsuki A. Familial hypercholesterolemia. J Atheroscler Thromb. 2014 Jan 23;21(1):6-10.

    116. Teramoto T, Sasaki J, Ishibashi S, Birou S, Daida H, Dohi S, Egusa G, Hiro T, Hirobe K, Iida M, Kihara S, Kinoshita M, Maruyama C, Ohta T, Okamura T, Yamashita S, Yokode M, Yokote K. The elderly. J Atheroscler Thromb. 2014 Mar 27;21(3):180-5.

    117. Teramoto T, Sasaki J, Ishibashi S, Birou S, Daida H, Dohi S, Egusa G, Hiro T, Hirobe K, Iida M, Kihara S, Kinoshita M, Maruyama C, Ohta T, Okamura T, Yamashita S, Yokode M, Yokote K. Cerebrovascular diseases. J Atheroscler Thromb. 2014 Mar 27;21(3):175-9.

    118. Teramoto T, Sasaki J, Ishibashi S, Birou S, Daida H, Dohi S, Egusa G, Hiro T, Hirobe K, Iida M, Kihara S, Kinoshita M, Maruyama C, Ohta T, Okamura T, Yamashita S, Yokode M, Yokote K. Chronic kidney disease. J Atheroscler Thromb. 2014 Mar 27;21(3):173-4.

    119. Teramoto T, Sasaki J, Ishibashi S, Birou S, Daida H, Dohi S, Egusa G, Hiro T, Hirobe K, Iida M, Kihara S, Kinoshita M, Maruyama C, Ohta T, Okamura T, Yamashita S, Yokode M, Yokote K. Diabetes mellitus. Executive summary of the Japan Atherosclerosis Society (JAS) guidelines for the diagnosis and prevention of atherosclerotic cardiovascular diseases in Japan–2012 version. J Atheroscler Thromb. 2014;21(2):93-8.

    120. Teramoto T, Sasaki J, Ishibashi S, Birou S, Daida H, Dohi S, Egusa G, Hiro T, Hirobe K, Iida M, Kihara S, Kinoshita M, Maruyama C, Ohta T, Okamura T, Yamashita S, Yokode M, Yokote K. Coronary artery disease. Executive summary of the Japan Atherosclerosis Society (JAS) guidelines for the diagnosis and prevention of atherosclerotic cardiovascular diseases in Japan–2012 version. J Atheroscler Thromb. 2014;21(2):86-92.

    121. Teramoto T, Sasaki J, Ishibashi S, Birou S, Daida H, Dohi S, Egusa G, Hiro T, Hirobe K, Iida M, Kihara S, Kinoshita M, Maruyama C, Ohta T, Okamura T, Yamashita S, Yokode M, Yokote K. Other types of primary hyperlipoproteinemia(hyperlipidemia). Executive summary of the Japan Atherosclerosis Society (JAS) guidelines for the diagnosis and prevention of atherosclerotic cardiovascular diseases in Japan–2012 version. J Atheroscler Thromb. 2014;21(2):82-5.

    122. Teramoto T, Sasaki J, Ishibashi S, Birou S, Daida H, Dohi S, Egusa G, Hiro T, Hirobe K, Iida M, Kihara S, Kinoshita M, Maruyama C, Ohta T, Okamura T, Yamashita S, Yokode M, Yokote K. Metabolic syndrome. J Atheroscler Thromb. 2014 Jan 23;21(1):1-5.

    123. Chiang SJ, Daimon M, Ishii K, Kawata T, Miyazaki S, Hirose K, Ichikawa R, Miyauchi K, Yeh MH, Chang NC, Daida H. Assessment of elevation of and rapid change in left ventricular filling pressure using a novel global strain imaging diastolic index. Circ J. 2014;78(2):419-27.

    124. Ueno Y, Yamashiro K, Tanaka Y, Watanabe M, Shimada Y, Kuroki T, Miyamoto N, Daimon M, Tanaka R, Miyauchi K, Daida H, Hattori N, Urabe T. Rationale and design of the EPISTEME trial: efficacy of post-stroke intensive rosuvastatin treatment for aortogenic embolic stroke. Cardiovasc Drugs Ther. 2014 Feb;28(1):79-85

    125. Naito R, Miyauchi K, Ogita M, Kasai T, Kawaguchi Y, Tsuboi S, Konishi H, Okazaki S, Kurata T, Daida H. Impact of admission glycemia and glycosylated hemoglobin A1c on long-term clinical outcomes of non-diabetic patients with acute coronary syndrome. J Cardiol. 2014 Feb;63(2):106-11.

    126. Ogita M, Miyauchi K, Miyazaki T, Naito R, Konishi H, Tsuboi S, Dohi T, Kasai T, Yokoyama T, Okazaki S, Kurata T, Daida H. Low high-density lipoprotein cholesterol is a residual risk factor associated with long-term clinical outcomes in diabetic patients with stable coronary artery disease who achieve optimal control of low-density lipoprotein cholesterol. Heart Vessels. 2014 Jan;29(1):35-41.

    127. Suyama M, Koik M, Asaoka D, Mori H, Oguro M, Ueno T, Nagahara A, Watanabe S, Uchiyama U (2014) Increased immunoreactivity of cathepsins in the rat esophagus under chronic acid reflux esophagitis. J Histochem Cytochem 62:645-660

    128. Sakuraba M, Murata J, Teruyama R, Kamiya K, Yamaguchi J, Okano Y, Uchiyama Y, Ikeda K (2014) Spatotemporal expression of TRPM4 in the mouse cochlea. J Neurosci Res 92:1409-1418

    129. Ueshima　S, Nishida T, Koike M, Matsuda H, Sawa Y, Uchiyama Y (2014) Nirtic oxide-mediated injury of interstitial cells of Cajal and intestinal dysmotility under endotoxemia. Biomed Res 35:251-262

    130. Bartolomé A, Kimura-Koyanagi M, Asahara S, Guillén C, Teruyama K, Inoue H, Shimizu S, Kanno A, García-Aguilar A, Koike M, Uchiyama Y, Benito M, Noda T, Kido Y (2014) Pancreatic β cell failure mediated by mTORC1 hyperactivity and autophagic Pancreatic β cell failure mediated by mTORC1 hyperactivity and autophagic impairment. Diabetes

    131. Nakafuku-Fukuda M, Hirata T, Keto Y, Yamano M, Yokoyama T, Uchiyama Y (2014) Inhibitory effect of the selective secretion 5-HT receptor antagonist ramosetron on duodenal acidification-induced gastric hypersensitivity in rats. Eur J Pharmacol 731:88-92 doi: 10.1016/j.ejphar.2014.02.040.

    132. Yamanaka T, Tosaki A, Kurosawa M, Matsumoto G, Koike M, Uchiyama Y, Maity SN, Shimogori T, Hattori N, Nukina N (2014) NF-Y inactivation causes atypical neurodegeneration characterized by ubiquitin and p62 accumulation and endoplasmic reticulum disorganization. Nat Commun doi:10.1038/ncomms4354

    133. Yokono M, Takasu T, Hayashizaki Y, Mitsuoka K, Kihara R, Muramatsu Y, Miyoshi S, Tahara A, Kurosaki E, Li Q, Tomiyama H, Sasamata M, Shibasaki M, Uchiyama Y (2014) SGLT2 selective inhibitor ipragliflozin reduces body fat mass by increasing fatty acid oxidation in high-fat diet-induced obese rats. Eur J Pharmacol 727-66-74 doi: 10.1016/j.erphar.2014.01.004

    134. Awazawa M, Futami T, Sakada M, Kaneko K, Ohsugi M, Nakaya K, Terai A, Suzuki R, Koike M, Uchiyama Y, Kadowaki T, Ueki K (2014) Deregulation of Pancreas-Specific Oxidoreductin ERO1β in the Pathogenesis of Diabetes Mellitus. Mol Cell Biol 34:1290-1299 doi:10.1128/MCB.01647-13

    135. Kashima J, Shintani-Ishida K, Nakajima M, Maeda H, Unuma K, Uchiyama Y, Yoshida K (2014) Immunocytochemical study of the autophagy marker microtubule-associated protein 1 light chain 3 in normal and steatotic human livers. Hepatol Res, 44:779-787, DOI: 10.1111/hepr.12183