業績

  • 2021年

    英文原著

    1Furuta T, Yamauchi K, Okamoto S, Takahashi M, Kakuta S, Ishida Y, Takenaka A, Yoshida A, Uchiyama Y, Koike M, Isa K, Isa T, Hioki H. Multi-scale light microscopy/electron microscopy neuronal imaging from brain to synapse with a tissue clearing method, ScaleSF. iScience. 2021 Dec 27;25(1):103601.
    2Segawa K, Kikuchi A, Noji T, Sugiura Y, Hiraga K, Suzuki C, Haginoya K, Kobayashi Y, Matsunaga M, Ochiai Y, Yamada K, Nishimura T, Iwasawa S, Shoji W, Sugihara F, Nishino K, Kosako H, Ikawa M, Uchiyama Y, Suematsu M, Ishikita H, Kure S, Nagata S. A sublethal ATP11A mutation associated with neurological deterioration causes aberrant phosphatidylcholine flipping in plasma membranes. J Clin Invest. 2021 Sep 15;131(18):e148005.
    3Claude-Taupin A, Jia J, Bhujabal Z, Garfa-Traoré M, Kumar S, da Silva GPD, Javed R, Gu Y, Allers L, Peters R, Wang F, da Costa LJ, Pallikkuth S, Lidke KA, Mauthe M, Verlhac P, Uchiyama Y, Salemi M, Phinney B, Tooze SA, Mari MC, Johansen T, Reggiori F, Deretic V. ATG9A protects the plasma membrane from programmed and incidental permeabilization. Nat Cell Biol. 2021 Aug;23(8):846-858.
    4Maruyama K, Yoneda K, Sugita S, Yamamoto Y, Koike M, Peters C, Uchiyama Y, Nishida K. CTLA-2 Alpha Is a Potent Inhibitor of Angiogenesis in Murine Ocular Tissue. Antioxidants (Basel). 2021 Mar 15;10(3):456.
    5Iwama H, Mehanna S, Imasaka M, Hashidume S, Nishiura H, Yamamura KI, Suzuki C, Uchiyama Y, Hatano E, Ohmuraya M. Cathepsin B and D deficiency in the mouse pancreas induces impaired autophagy and chronic pancreatitis. Sci Rep. 2021 Mar 23;11(1):6596.
    6Watanabe K, Morishitaa K, Zhou X, a S, Uchiyama Y, Koike M, Naguro I, Ichijo H. Cells recognize osmotic stress through liquid-liquid phase separation lubricated with poly(ADP-ribose). Nat Commun. 2021 Mar 1;12(1):1353.
    7Sato S, Noda S, Torii S, Amo T, Ikeda A, Funayama M, Yamaguchi J, Fukuda T, Kondo H, Tada N, Arakawa S, Watanabe M, Uchiyama Y, Shimizu S, Hattori N. Homeostatic p62 levels and inclusion body formation in CHCHD2 knockout mice. Hum Mol Genet. 2021 Apr 30;30(6):443-453.
    8Daida K, Nishioka K, Li Y, Yoshino H, Shimada T, Dougu N, Nakatsuji Y, Ohara S, Hashimoto T, Okiyama R, Yokochi F, Suzuki C, Tomiyama M, Kimura K, Ueda N, Tanaka F, Yamada H, Fujioka S, Tsuboi Y, Uozumi T, Takei T, Matsuzaki S, Shibasaki M, Kashihara K, Kurisaki R, Yamashita T, Fujita N, Hirata Y, Ii Y, Wada C, Eura N, Sugie K, Higuchi Y, Kojima F, Imai H, Noda K, Shimo Y, Funayama M, Hattori N. PLA2G6 variants associated with the number of affected alleles in Parkinson’s disease in Japan. Neurobiol Aging. 2021 Jan;97:147.e1-147.e9.
    9Hayashida A, Li Y, Yoshino H, Daida K, Ikeda A, Ogaki K, Fuse A, Mori A, Takanashi M, Nakahara T, Yoritaka A, Tomizawa Y, Furukawa Y, Kanai K, Nakayama Y, Ito H, Ogino M, Hattori Y, Hattori T, Ichinose Y, Takiyama Y, Saito T, Kimura T, Aizawa H, Shoji H, Mizuno Y, Matsushita T, Sato M, Sekijima Y, Morita M, Iwasaki A, Kusaka H, Tada M, Tanaka F, Sakiyama Y, Fujimoto T, Nagara Y, Kashihara K, Todo H, Nakao K, Tsuruta K, Yoshikawa M, Hara H, Yokote H, Murase N, Nakamagoe K, Tamaoka A, Takamiya M, Morimoto N, Nokura K, Kako T, Funayama M, Nishioka K, Hattori N. The identified clinical features of Parkinson’s disease in homo-, heterozygous and digenic variants of PINK1. Neurobiol Aging. 2021 Jan;97:146.e1-146.e13.
    10Hattori N, Yamashiro Y. The Gut-Brain Axis. Ann Nutr Metab. 2021 Jan 6:1-3. doi: 10.1159/000512226. Epub ahead of print. PMID: 33406517.
    11Mishima T, Fujioka S, Nishioka K, Li Y, Sato K, Houzen H, Yabe I, Shiomi K, Eriguchi M, Hara H, Hattori N, Tsuboi Y. Meta-iodobenzylguanidine myocardial scintigraphy in Perry disease. Parkinsonism Relat Disord. 2021 Feb;83:49-53.
    12Mochizuki H, Hattori N, Hasegawa K, Nomoto M, Uchida E, Terahara T, Okawa K, Fukuta H. Long-term study of ropinirole patch in Parkinson’s disease patients with/without basal l-dopa. Parkinsonism Relat Disord. 2021 Feb;83:105-109.
    13Nomoto M, Takeda A, Iwai K, Nishimura A, Hattori N. Effect of Opicapone Tablets on Levodopa and 3-O-Methyldopa Pharmacokinetics in Healthy Japanese Subjects: Phase 1 Study. Clin Pharmacol Drug Dev. 2021 Feb;10(2):180-189.
    14Nomoto M, Takeda A, Iwai K, Nishimura A, Hattori N. Pharmacokinetic Comparison of Capsule and Tablet Formulations of Opicapone in Healthy Japanese Subjects: Phase 1 Study. Clin Pharmacol Drug Dev. 2021 Feb;10(2):173-179.
    15Takeda A, Takahashi R, Tsuboi Y, Nomoto M, Maeda T, Nishimura A, Yoshida K, Hattori N. Randomized, Controlled Study of Opicapone in Japanese Parkinson’s Patients with Motor Fluctuations. Mov Disord. 2021 Feb;36(2):415-423.
    16Shimura H, Saiko A, Hayashi A, Hattori N, Urabe T. Rivastigmine improves dual-task gait velocity in patients with Alzheimer’s disease. BMC Neurol. 2021 Feb 10;21(1):61.
    17Oji Y, Hatano T, Funayama M, Hattori N. Reply: Association analysis of PSAP variants in Parkinson’s disease patients. Brain. 2021 Feb 12;144(1):e10.
    18Iijima M, Okuma Y, Suzuki K, Yoshii F, Nogawa S, Osada T, Hirata K, Kitagawa K, Hattori N. Associations between probable REM sleep behavior disorder, olfactory disturbance, and clinical symptoms in Parkinson’s disease: A multicenter cross-sectional study. PLoS One. 2021 Feb 19;16(2):e0247443.
    19Hamamichi S, Fukuhara T, Umeda IO, Fujii H, Hattori N. Novel method for screening functional antibody with comprehensive analysis of its immunoliposome. Sci Rep. 2021 Feb 25;11(1):4625.
    20Fujita S, Yokoyama K, Hagiwara A, Kato S, Andica C, Kamagata K, Hattori N, Abe O, Aoki S. 3D Quantitative Synthetic MRI in the Evaluation of Multiple Sclerosis Lesions. AJNR Am J Neuroradiol. 2021 Mar;42(3):471-478.
    21Ishiguro M, Li Y, Yoshino H, Daida K, Ishiguro Y, Oyama G, Saiki S, Funayama M, Hattori N, Nishioka K. Clinical manifestations of Parkinson’s disease harboring VPS35 retromer complex component p.D620N with long-term follow-up. Parkinsonism Relat Disord. 2021 Mar;84:139-143.
    22Kimura Y, Sato N, Ishiyama A, Shigemoto Y, Suzuki F, Fujii H, Maikusa N, Matsuda H, Nishioka K, Hattori N, Sasaki M. Serial MRI alterations of pediatric patients with beta-propeller protein associated neurodegeneration (BPAN). J Neuroradiol. 2021 Mar;48(2):88-93.
    23Sasaki F, Oyama G, Sekimoto S, Nuermaimaiti M, Iwamuro H, Shimo Y, Umemura A, Hattori N. Closed-loop programming using external responses for deep brain stimulation in Parkinson’s disease. Parkinsonism Relat Disord. 2021 Mar;84:47-51.
    24Takeda A, Takahashi R, Tsuboi Y, Nomoto M, Maeda T, Nishimura A, Yoshida K, Hattori N. Long-term safety and efficacy of opicapone in Japanese Parkinson’s patients with motor fluctuations. J Neural Transm (Vienna). 2021 Mar;128(3):337-344.
    25Taniguchi T, Ando M, Okamoto Y, Yoshimura A, Higuchi Y, Hashiguchi A, Shiga K, Hayashida A, Hatano T, Ishiura H, Mitsui J, Hattori N, Mizuno T, Nakagawa M, Tsuji S, Takashima H. Genetic spectrum of Charcot-Marie-Tooth disease associated with myelin protein zero gene variants in Japan. Clin Genet. 2021 Mar;99(3):359-375.
    26Uddin MN, Elahi M, Shimonaka S, Kakuta S, Ishiguro K, Motoi Y, Hattori N. Strain-specific clearance of seed-dependent tau aggregation by lithium-induced autophagy. Biochem Biophys Res Commun. 2021 Mar 5;543:65-71.
    27Cossu D, Yokoyama K, Sakanishi T, Kuwahara-Arai K, Momotani E, Hattori N. A mucosal immune response induced by oral administration of heat-killed Mycobacterium avium subsp. paratuberculosis exacerbates EAE. J Neuroimmunol. 2021 Mar 15;352:577477.
    28Yokota M, Kakuta S, Shiga T, Ishikawa KI, Okano H, Hattori N, Akamatsu W, Koike M. Establishment of an in vitro model for analyzing mitochondrial ultrastructure in PRKN-mutated patient iPSC-derived dopaminergic neurons. Mol Brain. 2021 Mar 23;14(1):58.
    29Ogawa T, Ogaki K, Mori Y, Kamo H, Uchiyama A, Kamagata K, Nagaoka M, Hattori N. Neuronuclear and Neuromelanin-Sensitive Imaging for Acquired Hepatocerebral Degeneration with Parkinsonism. Mov Disord Clin Pract. 2021 Mar 26;8(3):464-468.
    30Doijiri R, Ueno Y, Kikuno M, Shimizu T, Tateishi Y, Kuriki A, Takekawa H, Shimada Y, Kanemaru K, Kamiya Y, Yamaguchi E, Koga M, Ihara M, Tsujino A, Hirata K, Hasegawa Y, Kikuchi T, Hattori N, Urabe T. Different aspects of early and late development of atrial fibrillation during hospitalization in cryptogenic stroke. Sci Rep. 2021 Mar 29;11(1):7127.
    31Fukae J, Kano M, Nakajima A, Fuse A, Eguchi H, Ashisawa K, Takanashi M, Hattori N, Shimo Y. Acute gastric dilatation is a potentially fatal complication in Parkinson’s disease. Parkinsonism Relat Disord. 2021 Apr;85:69-71.
    32Hayashi T, Shimonaka S, Elahi M, Matsumoto SE, Ishiguro K, Takanashi M, Hattori N, Motoi Y. Learning Deficits Accompanied by Microglial Proliferation After the Long-Term Post-Injection of Alzheimer’s Disease Brain Extract in Mouse Brains. J Alzheimers Dis. 2021;79(4):1701-1711.
    33Oyama G, Hattori N. New modalities and directions for dystonia care. J Neural Transm (Vienna). 2021 Apr;128(4):559-565.
    34Ogata J, Hirao K, Nishioka K, Hayashida A, Li Y, Yoshino H, Shimizu S, Hattori N, Imai Y. A Novel LRRK2 Variant p.G2294R in the WD40 Domain Identified in Familial Parkinson’s Disease Affects LRRK2 Protein Levels. Int J Mol Sci. 2021 Apr 2;22(7):3708.
    35Farrer MJ, Bardien S, Hattori N, Lesage S, Ross OA, Mellick GD, Kruger R. Editorial: Celebrating the Diversity of Genetic Research to Dissect the Pathogenesis of Parkinson’s Disease. Front Neurol. 2021 Apr 6;12:648417.
    36Nakajima S, Tanaka R, Yamashiro K, Chiba A, Noto D, Inaba T, Kurita N, Miyamoto N, Kuroki T, Shimura H, Ueno Y, Urabe T, Miyake S, Hattori N. Mucosal- Associated Invariant T Cells Are Involved in Acute Ischemic Stroke by Regulating Neuroinflammation. J Am Heart Assoc. 2021 Apr 6;10(7):e018803.
    37Oji Y, Hatano T, Funayama M, Hattori N. Reply: PSAP variants in Parkinson’s disease: a large cohort study in Chinese mainland population. Brain. 2021 Apr 12;144(3):e26.
    38Ueno Y, Saito A, Nakata J, Kamagata K, Taniguchi D, Motoi Y, Io H, Andica C, Shindo A, Shiina K, Miyamoto N, Yamashiro K, Urabe T, Suzuki Y, Aoki S, Hattori N. Possible Neuroprotective Effects of l-Carnitine on White-Matter Microstructural Damage and Cognitive Decline in Hemodialysis Patients. Nutrients. 2021 Apr 14;13(4):1292.
    39Shimada T, Uchida W, Shindo A, Kamagata K, Hattori N, Tsunemi T. Delayed- onset motor aphasia succeeds Holmes’ tremor and neuropathic pain after left thalamic hemorrhage. J Neurol Sci. 2021 Apr 15;423:117367.
    40Sato S, Noda S, Torii S, Amo T, Ikeda A, Funayama M, Yamaguchi J, Fukuda T, Kondo H, Tada N, Arakawa S, Watanabe M, Uchiyama Y, Shimizu S, Hattori N. Homeostatic p62 levels and inclusion body formation in CHCHD2 knockout mice. Hum Mol Genet. 2021 Apr 30;30(6):443-453. doi: 10.1093/hmg/ddab057. PMID: 33631794.
    41Hagiwara A, Otsuka Y, Andica C, Kato S, Yokoyama K, Hori M, Fujita S, Kamagata K, Hattori N, Aoki S. Differentiation between multiple sclerosis and neuromyelitis optica spectrum disorders by multiparametric quantitative MRI using convolutional neural network. J Clin Neurosci. 2021 May;87:55-58.
    42Tokarew JM, El-Kodsi DN, Lengacher NA, Fehr TK, Nguyen AP, Shutinoski B, O’Nuallain B, Jin M, Khan JM, Ng ACH, Li J, Jiang Q, Zhang M, Wang L, Sengupta R, Barber KR, Tran A, Im DS, Callaghan S, Park DS, Zandee S, Dong X, Scherzer CR, Prat A, Tsai EC, Takanashi M, Hattori N, Chan JA, Zecca L, West AB, Holmgren A, Puente L, Shaw GS, Toth G, Woulfe JM, Taylor P, Tomlinson JJ, Schlossmacher MG. Age-associated insolubility of parkin in human midbrain is linked to redox balance and sequestration of reactive dopamine metabolites. Acta Neuropathol. 2021 May;141(5):725-754.
    43Yamashita Y, Takahashi Y, Tsunemi T, Shirane S, Nakazato-Taniguchi T, Taniguchi D, Takanashi M, Sasaki M, Komatsu N, Hattori N. Systemic Sclerosis Precedes POEMS Syndrome. Can J Neurol Sci. 2021 May;48(3):446-449.
    44Itai T, Miyatake S, Hatano T, Hattori N, Ohno A, Aoki Y, Itomi K, Mori H, Saitsu H, Matsumoto N. Cerebrovascular diseases in two patients with entire NSD1 deletion. Hum Genome Var. 2021 May 24;8(1):20.
    45Ishiguro M, Yoshino H, Li Y, Ikeda A, Funayama M, Nishioka K, Hattori N. Genetic analysis of ATP10B for Parkinson’s disease in Japan. Parkinsonism Relat Disord. 2021 Jul;88:10-12.
    46Yamashiro K, Kurita N, Urabe T, Hattori N. Role of the Gut Microbiota in Stroke Pathogenesis and Potential Therapeutic Implications. Ann Nutr Metab. 2021;77 Suppl 2:36-44.
    47Domenighetti C, Sugier PE, Sreelatha AAK, Schulte C, Grover S, Mohamed O, Portugal B, May P, Bobbili DR, Radivojkov-Blagojevic M, Lichtner P, Singleton AB, Hernandez DG, Edsall C, Mellick GD, Zimprich A, Pirker W, Rogaeva E, Lang AE, Koks S, Taba P, Lesage S, Brice A, Corvol JC, Chartier-Harlin MC, Mutez E, Brockmann K, Deutschländer AB, Hadjigeorgiou GM, Dardiotis E, Stefanis L, Simitsi AM, Valente EM, Petrucci S, Duga S, Straniero L, Zecchinelli A, Pezzoli G, Brighina L, Ferrarese C, Annesi G, Quattrone A, Gagliardi M, Matsuo H, Kawamura Y, Hattori N, Nishioka K, Chung SJ, Kim YJ, Kolber P, van de Warrenburg BP, Bloem BR, Aasly J, Toft M, Pihlstrøm L, Guedes LC, Ferreira JJ, Bardien S, Carr J, Tolosa E, Ezquerra M, Pastor P, Diez-Fairen M, Wirdefeldt K, Pedersen NL, Ran C, Belin AC, Puschmann A, Hellberg C, Clarke CE, Morrison KE, Tan M, Krainc D, Burbulla LF, Farrer MJ, Krüger R, Gasser T, Sharma M, Elbaz A; Comprehensive Unbiaised Risk Factor Assessment for Genetics and Environment in Parkinson’s Disease (Courage-PD) consortium. Mendelian Randomisation Study of Smoking, Alcohol, and Coffee Drinking in Relation to Parkinson’s Disease. J Parkinsons Dis. 2 22;12(1):267-282.
    48Nan H, Kim YJ, Tsuchiya M, Fukao T, Hara N, Hagihara A, Nishioka K, Hattori N, Hara N, Ikeuchi T, Ohtsuka T, Takiyama Y. A Novel Heterozygous Missense Variant in the CIAO1 Gene in a Family with Alzheimer’s Disease: The Val67Ile Variant Promotes the Interaction of CIAO1 and Amyloid-β Protein Precursor. J Alzheimers Dis. 2021;84(2):599-605.
    49Ogata J, Takemoto D, Shimonaka S, Imai Y, Hattori N. α-Synuclein Seeding Assay Using Cultured Cells. Methods Mol Biol. 2021;2322:27-39.
    50Okuzumi A, Hatano T, Fukuhara T, Ueno S, Nukina N, Imai Y, Hattori N. α-Synuclein Seeding Assay Using RT-QuIC. Methods Mol Biol. 2021;2322:3-16.
    51Shojima Y, Ogata J, Tsunemi T, Imai Y, Hattori N. Measurement of GCase Activity in Cultured Cells. Methods Mol Biol. 2021;2322:47-52.
    52Tsunemi T, Ishiguro Y, Yoroisaka A, Hattori N. Analysis of α-Synuclein in Exosomes. Methods Mol Biol. 2021;2322:41-45.
    53Cossu D, Yokoyama K, Sechi LA, Hattori N. Potential of PINK1 and PARKIN Proteins as Biomarkers for Active Multiple Sclerosis: A Japanese Cohort Study. Front Immunol. 2021 Aug 4;12:681386.
    54Kataura T, Tashiro E, Nishikawa S, Shibahara K, Muraoka Y, Miura M, Sakai S, Katoh N, Totsuka M, Onodera M, Shin-Ya K, Miyamoto K, Sasazawa Y, Hattori N, Saiki S, Imoto M. A chemical genomics-aggrephagy integrated method studying functional analysis of autophagy inducers. Autophagy. 2021 Aug;17(8):1856-1872.
    55Pilotto A, Romagnolo A, Scalvini A, Masellis M, Shimo Y, Bonanni L, Camicioli R, Wang LL, Dwivedi AK, Longardner K, Rodriguez-Porcel F, DiFrancesco M, Vizcarra JA, Montanaro E, Maule S, Lupini A, Ojeda-López C, Black SE, Delli Pizzi S, Gee M, Tanaka R, Yamashiro K, Hatano T, Borroni B, Gasparotti R, Rizzetti MC, Hattori N, Lopiano L, Litvan I, Espay AJ, Padovani A, Merola A. Association of Orthostatic Hypotension With Cerebral Atrophy in Patients With Lewy Body Disorders. Neurology. 2021 Aug 24;97(8):e814-e824. doi:10.1212/WNL.0000000000012342.
    56Elahi M, Motoi Y, Shimonaka S, Ishida Y, Hioki H, Takanashi M, Ishiguro K, Imai Y, Hattori N. High-fat diet-induced activation of SGK1 promotes Alzheimer’s disease-associated tau pathology. Hum Mol Genet. 2021 Aug 28;30(18):1693-1710.
    57Tateishi Y, Ueno Y, Tsujino A, Kuriki A, Kamiya Y, Shimizu T, Doijiri R, Yamaguchi E, Kikuno M, Shimada Y, Takekawa H, Koga M, Ihara M, Hirata K, Hasegawa Y, Toyoda K, Hattori N, Urabe T; CHALLENGE ESUS/CS collaborators. Cardiac and Echocardiographic Markers in Cryptogenic Stroke with Incidental Patent Foramen Ovale. J Stroke Cerebrovasc Dis. 2021 Aug;30(8):105892.
    58Sakurai A, Tsunemi T, Ishiguro Y, Okuzumi A, Hatano T, Hattori N. Comorbid alpha synucleinopathies in idiopathic normal pressure hydrocephalus. J Neurol. 2021 Sep 1. doi: 10.1007/s00415-021-10778-1. Epub ahead of print
    59Ogawa T, Ogaki K, Daida K, Nishimaki T, Ando M, Kawajiri S, Wada R, Noda K, Hattori N, Okuma Y. Progressive Encephalomyelitis with Rigidity and Myoclonus and Myasthenia Gravis Comorbid Status with Thymoma. Mov Disord Clin Pract. 2021 Sep 3;8(Suppl 1):S11-S13.
    60Yasaka K, Kamagata K, Ogawa T, Hatano T, Takeshige-Amano H, Ogaki K, Andica C, Akai H, Kunimatsu A, Uchida W, Hattori N, Aoki S, Abe O. Parkinson’s disease: deep learning with a parameter-weighted structural connectome matrix for diagnosis and neural circuit disorder investigation. Neuroradiology. 2021 Sep;63(9):1451-1462.
    61Hasegawa H, Yatomi K, Mitome-Mishima Y, Miyamoto N, Tanaka R, Oishi H, Arai H, Hattori N, Urabe T. Pioglitazone Prevents Hemorrhagic Infarction After Transient Focal Ischemia in Type 2 Diabetes. Neurosci Res. 2021 Sep;170:314-321.
    62Uehara Y, Ueno SI, Amano-Takeshige H, Suzuki S, Imamichi Y, Fujimaki M, Ota N, Murase T, Inoue T, Saiki S, Hattori N. Non-invasive diagnostic tool for Parkinson’s disease by sebum RNA profile with machine learning. Sci Rep. 2021 Sep 20;11(1):18550.
    63Hung YC, Huang KL, Chen PL, Li JL, Lu SH, Chang JC, Lin HY, Lo WC, Huang SY, Lee TT, Lin TY, Imai Y, Hattori N, Liu CS, Tsai SY, Chen CH, Lin CH, Chan CC. UQCRC1 engages cytochrome c for neuronal apoptotic cell death. Cell Rep. 2021 Sep 21;36(12):109729.
    64Osada T, Ogawa A, Suda A, Nakajima K, Tanaka M, Oka S, Kamagata K, Aoki S, Oshima Y, Tanaka S, Hattori N, Konishi S. Parallel cognitive processing streams in human prefrontal cortex: Parsing areal-level brain network for response inhibition. Cell Rep. 2021 Sep 21;36(12):109732.
    65Shimo Y, Maeda T, Chiu SW, Yamaguchi T, Kashihara K, Tsuboi Y, Nomoto M, Hattori N, Watanabe H, Saiki H; J-FIRST Group. Influence of istradefylline on non-motor symptoms of Parkinson’s disease: A subanalysis of a 1-year observational study in Japan (J-FIRST). Parkinsonism Relat Disord. 2021 Oct;91:115-120.
    66Koinuma T, Hatano T, Kamagata K, Andica C, Mori A, Ogawa T, Takeshige-Amano H, Uchida W, Saiki S, Okuzumi A, Ueno SI, Oji Y, Saito Y, Hori M, Aoki S, Hattori N. Diffusion MRI Captures White Matter Microstructure Alterations in PRKN Disease. J Parkinsons Dis. 2021;11(3):1221-1235.
    67Cossu D, Yokoyama K, Sato S, Noda S, Sechi LA, Hattori N. PARKIN modifies peripheral immune response and increases neuroinflammation in active experimental autoimmune encephalomyelitis (EAE). J Neuroimmunol. 2021 Oct 15;359:577694.
    68Fukushima H, Shibuya T, Awatsu T, Kurosawa T, Haga K, Murakami T, Serizawa N, Mori A, Hojo M, Yao T, Hattori N, Nagahara A. CV2/CRMP5-antibody-related Paraneoplastic Neurologic Syndrome Associated with Gastrointestinal Stromal Tumor. Intern Med. 2021 Oct 19.
    69Someya Y, Tamura Y, Kaga H, Sugimoto D, Kadowaki S, Suzuki R, Aoki S, Hattori N, Motoi Y, Shimada K, Daida H, Ishijima M, Kaneko K, Nojiri S, Kawamori R, Watada H. Insulin resistance and muscle weakness are synergistic risk factors for silent lacunar infarcts: the Bunkyo Health Study. Sci Rep. 2021 Oct 26;11(1):21093.
    70Someya Y, Tamura Y, Kaga H, Sugimoto D, Kadowaki S, Suzuki R, Aoki S, Hattori N, Motoi Y, Shimada K, Daida H, Ishijima M, Kaneko K, Nojiri S, Kawamori R, Watada H. Insulin resistance and muscle weakness are synergistic risk factors for silent lacunar infarcts: the Bunkyo Health Study. Sci Rep. 2021 Oct 26;11(1):21093.
    71Ogawa T, Hatano T, Kamagata K, Andica C, Takeshige-Amano H, Uchida W, Kamiyama D, Shimo Y, Oyama G, Umemura A, Iwamuro H, Ito M, Hori M, Aoki S, Hattori N. White matter and nigral alterations in multiple system atrophy- parkinsonian type. NPJ Parkinsons Dis. 2021 Oct 29;7(1):96.
    72Cook L, Schulze J, Verbrugge J, Beck JC, Marder KS, Saunders-Pullman R, Klein C, Naito A, Alcalay RN; ClinGen Parkinson’s Disease Gene Curation Expert Panel and the MDS Task Force for Recommendations for Genetic Testing in Parkinson’s Disease; Clinical Genome Resource (ClinGen) Parkinson’s Disease Gene Curation Expert Panel Authors; Movement Society Disorder (MDS) Task Force on Recommendations for Clinical Genetic Testing in Parkinson’s Disease Authors. The commercial genetic testing landscape for Parkinson’s disease. Parkinsonism Relat Disord. 2021 Nov;92:107-111.
    73Ko R, Shukuya T, Imamura C, Tokito T, Shimada N, Koyama R, Yamada K, Ishii H, Azuma K, Takahashi K. Phase I study of afatinib plus bevacizumab in patients with advanced non-squamous non-small cell lung cancer harboring EGFR mutations. Transl Lung Cancer Res., 2021;10(1): 183-192.
    74Miyawaki T, Wakuda K, Kenmotsu H, Miyawaki E, Mamesaya N, Kobayashi H, Omori S, Ono A, Naito T, Murakami H, Notsu A, Mori K, Harada H, Endo M, Ohde Y, Takahashi K, Takahashi T. Proposing Synchronous Oligometastatic Non-Small Cell Lung Cancer Based on Progression after First-line Systemic Therapy. Cancer Sci., 2021;112(1): 359-368.
    75Kato M, Sasaki S, Tateyama M, Arai Y, Motomura H, Sumiyoshi I, Ochi Y, Watanabe J, Ihara H, Togo S, Takahashi K. Clinical Significance of Continuable Treatment with Nintedanib Over 12 Months for Idiopathic Pulmonary Fibrosis in a Real-World Setting. Drug Design, Development and Therapy., 2021; 15: 223-230.
    76Miyashita Y, Ko R, Shimada N, Mitsuishi Y, Miura K, Matsumoto N, Asao T, Shukuya T, Shibayama R, Koyama R, Takahashi K. Impact of the generation of EGFR-TKIs administered as priortherapy on the effcacy of osimertinib in patients with non-small cell lung cancer harboring EGFR T790M mutation. Thoracic Cancer. 2021;12: 329–338.
    77Wakita M, Idei M, Saito K, Horiuchi Y, Yamatani K, Ishikawa S, Yamamoto T, Igawa G, Hinata M, Kadota K, Kurosawa T, Takahashi S, Saito T, Misawa S, Akazawa C, Naito T, Miida T, Takahashi K, Ai T, Tabe Y. Comparison of the clinical performance and usefulness of five SARS-CoV-2 antibody tests. PLoS One. 2021;16(2): e0246536.
    78Sumiyoshi I, Okabe T, Togo S, Takagi H, Motomura H, Ochi Y, Shimada N, Haraguchi M, Shibayama R, Fujimoto Y, Watanabe J, Iwai M, Kadoya K, Iwakami SI, Takahashi K. High lymphocyte population-related predictive factors for a long-term response in non-small cell lung cancer patients treated with pemetrexed: a retrospective observational study. J Transl Med., 2021; 19(1): 92.
    79Asahina H, Tanaka K, Morita S, Maemondo M, Seike M, Okamoto I, Oizumi S, Kagamu H, Takahashi K, Kikuchi T, Isobe T, Sugio K, Kobayashi K. A Phase II Study of Osimertinib Combined With Platinum Plus Pemetrexed in Patients With EGFR-Mutated Advanced Non-Small-cell Lung Cancer: The OPAL Study (NEJ032C/LOGIK1801). Clin Lung Cancer., 2021; 22(2): 147-151.
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    221Shimizu Y, Gumin J, Gao F, Hossain A, Shpall EJ, Kondo A, Parker Kerrigan BC, Yang J, Ledbetter D, Fueyo J, Gomez-Manzano C, Lang FF.Characterization of patient-derived bone marrow human mesenchymal stem cells as oncolytic virus carriers for the treatment of glioblastoma,J Neurosurg. 2021 Aug 27:1-11.
    222K. Kawamura, M. Miyajima, M. Nakajima, M. Kanai, Y. Motoi, S. Nojiri, et al.Cerebrospinal Fluid Amyloid-beta Oligomer Levels in Patients with Idiopathic Normal Pressure Hydrocephalus,J Alzheimers Dis 2021
    223K. Sakamoto, M. Nakajima, K. Kawamura, E. Nakamura, N. Tada, A. Kondo, et al,Ependymal ciliary motion and their role in congenital hydrocephalus,Childs Nerv Syst 2021
    224M. Nakajima, S. Yamada, M. Miyajima, K. Kawamura, C. Akiba, H. Kazui, et al.Tap Test Can Predict Cognitive Improvement in Patients With iNPH-Results From the Multicenter Prospective Studies SINPHONI-1 and -2,Front Neurol 2021 Vol. 12 Pages 769216
    225Shimizu Y, Gumin J, Gao F, Hossain A, Shpall EJ, Kondo A, Parker Kerrigan BC, Yang J, Ledbetter D, Fueyo J, Gomez-Manzano C, Lang FF.Characterization of patient-derived bone marrow human mesenchymal stem cells as oncolytic virus carriers for the treatment of glioblastoma,J Neurosurg. 2021 Aug 27:1-11.
    英文総説
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    6Tanida　I, Yamaguchi J, Kakuta S, Uchiyama Y. In-resin CLEM of Epon-embedded cells using fluorescent proteins. JEOL news, 2021;56(1):25-30
    7Madoka Nakajima, Shigeki Yamada, Masakazu Miyajima, Kazunari Ishii, Nagato Kuriyama, Hiroaki Kazui, Hideki Kanemoto, Takashi Suehiro, Kenji Yoshiyama, Masahiro Kameda, Yoshinaga Kajimoto, Mitsuhito Mase, Hisayuki Murai, Daisuke Kita, Teruo Kimura, Naoyuki Samejima, Takahiko Tokuda, Mitsunobu Kaijima, Chihiro Akiba, Kaito Kawamura, Masamichi Atsuchi, Yoshihumi Hirata, Mitsunori Matsumae, Makoto Sasaki, Fumio Yamashita, Shigeki Aoki, Ryusuke Irie, Hiroji Miyake, Takeo Kato, Etsuro Mori, Masatsune Ishikawa, Isao Date, Hajime Arai, The research committee of idiopathic normal pressure hydrocephalus, Guidelines for Management of Idiopathic Normal Pressure Hydrocephalus (Third Edition): Endorsed by the Japanese Society of Normal Pressure Hydrocephalus. Neurol Med Chir (Tokyo). 2021; 61(2):63-97
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